Expression of the Prader Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression . ^^^ Recently , Necdin and other MAGE proteins were found to interact in vitro with the intracellular domain of the p75NTR neurotrophin receptor , but this interaction has not been validated in vivo . ^^^ We report here that the spatial and temporal expression of p75NTR is included in Necdin expression domain . ^^^ Furthermore , they are also consistent with the putative role of Necdin in signaling events promoted by p75NTR during mouse nervous system development . . ^^^ |