Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.71589992
A second intriguing feature of the 5 ' end of the RUB genomic RNA is the presence of a short ( 17 codons ) open reading frame ( ORF ) located between nt 3 and 54 ; the ORF encoding the viral nonstructural proteins ( NSPs ) initiates at nt 41 in an alternate translational frame . 0.71589992^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Based on RNase protection assays , the major transcription start point of MyoD is located 210 nt 5 ' to a methionine start codon and 26 nt 3 ' to a TAAATA motif which bears similarity to a consensus recognition sequence ( TATA ) utilized by eukaryotic RNA polymerase 2 transcription complexes . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Cu phenanthroline hypersensitive sites located 13 nt 5 ' and 4 nt 3 ' of the growing point appeared to demarcate the margins of the bubble . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Substitution analysis revealed that either these 6 nt 3 ' of the U 1 RNA or the conserved 3 ' box could direct 3 ' end formation . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We studied 23 patients with clinically defined mitochondrial encephalomyopathy , lactic acidosis , and stroke like episodes ( MELAS ) , 25 oligosymptomatic or asymptomatic maternal relatives , and 50 mitochondrial disease control subjects for the presence of a previously reported heteroplasmic point mutation at nt 3 , 243 in the transfer RNA ( Leu ( UUR ) ) gene of mitochondrial DNA . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The predominant L GP transcript was generated by polyadenylation 130 nt 3 ' from the end of the coding region . ^^^ A previously uncharacterized L GP transcript is generated by polyadenylation at 346 nt 3 ' of the first polyadenylation site . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The td enzyme was shown to cleave 23 26 nt 5 ' and the sunY endonuclease 13 15 nt 3 ' to the intron insertion site to generate 3 nt or 2 nt 3 ' OH extensions , respectively . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The nucleotide sequence variation observed was two to 13 differences in the 120 to 123 nt 5 ' non translated regions , six to 17 differences in the 840 nt 3a genes , two to 15 differences in the 296 to 299 nt intergenic regions , three to 25 differences in the 657 nt coat protein genes and two to 10 differences in the 299 to 303 nt 3 ' non translated regions . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Blood samples were drawn from control , nontransported mares ( NT 3 wk , NT 5 wk , n = 24 ) and transported mares pre trip , midtrip , and at 0 , 12 , 24 , 48 and 72 h post transport and daily for the next 2 wk . ^^^ Serum progesterone in all T mares increased ( P less than . 05 ) at midtrip relative to pre trip values and was higher ( P less than . 05 ) in T 3 wk mares than in NT 3 wk mares at midtrip and 0 h post transport . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The first , NT 3 , recognises only NT 1 13 in plasma extracts , while the second , GNT 21 , recognises NT 1 13 , NT 1 11 and NT 1 8 equally . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Transcripts terminating 196 nt 3 ' of the 5 ' splice site retain catalytic activity . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Transcription initiation of all mRNAs occurs at two major ( nt 1 and 8 ) and approximately two minor sites , situated 20 30 nt 3 ' to a TATA box . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Developmental changes in NT 3 signalling via TrkA and TrkB in embryonic neurons . ^^^ Neurotrophins promote neuronal survival by signalling through Trk receptor tyrosine kinases : nerve growth factor signals through TrkA , brain derived neurotrophic factor ( BDNF ) and neurotrophin ( NT ) 4 through TrkB and NT 3 through TrkC . ^^^ Although studies in some , but not all , cell lines indicate that NT 3 can also signal through TrkA and TrkB , it is not known if such signalling can occur in neurons . ^^^ We show that NT 3 can promote the in vitro survival of sensory and sympathetic neurons isolated from embryos that are homozygous for a null mutation in the trkC gene . ^^^ During the mid embryonic period , NT 3 promoted the survival of as many trigeminal and nodose neurons as the preferred neurotrophins , NGF and BDNF . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In vitro , cultured human smooth muscle cells express BDNF ; NT 3 ; and trk A , B , and C . ^^^ In human coronary atherosclerotic lesions , BDNF , NT 3 , and NT 4 / 5 , and the trk B and trk C receptors could be demonstrated in smooth muscle cells . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
It consists of an open reading frame of 726 nt flanked by a 84 nt 5 ' and a 307 nt 3 ' untranslated region . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The neurotrophins comprise a family of related molecules including nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF , neurotrophin 3 ( NT 3 ) and neurotrophin 4 / 5 ( NT 4 / 5 ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
A useful polymorphism was found in the 3 ' region of the ALAS 2 gene , a G to A transition , 220 nt 3 ' of the AATAAA polyadenylation signal . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We have examined a group of WT immunohistochemically with antibodies recognizing known trk receptor proteins , the p 75 receptor , and the NTs , NGF and NT 3 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The terminator region of the P . chrysogenum pgkA gene was sequenced as far as 192 nt 3 ' to the stop codon and three polyadenylation sites were found at 94 , 103 and 107 nt from this point , the first preceded by a possible polyadenylation signal . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To see whether glucocorticoid hormones can influence the regulation of neurotrophin expression in hippocampal neurons , we have used reverse transcription followed by polymerase chain reaction to investigate changes in the mRNA levels of nerve growth factor ( NGF ) and neurotrophin 3 ( NT 3 ) in immortalized hippocampal neurons after dexamethasone application . ^^^ Our results show that NGF mRNA levels rise in both embryonic and postnatal neurons , but with different time courses , while NT 3 levels rise in the embryonic but not in the postnatally derived cell line . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Several members of the neurotrophin ( NT ) family , including nerve growth factor ( NGF ) , NT 3 , and NT 4 / 5 , are expressed in the mammalian ovary . ^^^ No such changes in trkB or trkC mRNA were observed ; the abundance of these mRNAs , which encode the receptor tyrosine kinase for NT 4 / 5 and brain derived neurotrophic factor , and NT 3 , respectively , remained at very low levels throughout puberty . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The long form of the cDNA has 1165 nt 3 ' untranslated region while the 3 ' untranslated region in the short form is only 258 nt . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We have now used neurotrophic factors ( BDNF , NT 4 / 5 , NT 3 , NGF , LIF ) , glutamate receptor antagonists ( MK 801 , DNQX , CNQX ) , an antioxidant ( N ace tyl L cysteine ) , and an NOS inhibitor ( L NAME ) to determine whether the early and late phases of lesion induced RGC death involved similar or different mechanisms . ^^^ NT 4 / 5 and BDNF significantly decreased RGC pyknosis 6 and 24 hr PL , whereas NT 3 was only protective 6 hr PL . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
A 34 bp RNA DNA hybrid with a 19 nt 3 ' RNA tail was unwound catalytically , whereas a 34 bp DNA RNA hybrid containing a 19 nt 3 ' DNA tail was 2 orders of magnitude less effective as a helicase substrate . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To investigate the influences of growth factors on axonal regeneration in the mammalian CNS , we used intracellular tracers to quantitate the effects of brain derived neurotrophic factor ( BDNF ) , neurotrophin ( NT ) 4 / 5 , or NT 3 on individual retinal ganglion cell ( RGC ) axons in the retinas of adult rats after optic nerve transection . ^^^ NT 3 did not significantly influence axonal regrowth . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Here we found that treatment of 70W melanoma cells with neurotrophin NT 3 increased Matrigel invasion , whereas treatment with neurotrophins other than NGF or NT 3 did not influence invasion . ^^^ When 70W cells were exposed to antisense oligonucleotides directed against p75NTR mRNA , there was a reduction in NGF and NT 3 binding , and the neurotrophins failed to enhance Matrigel invasion . ^^^ Incubation of 70W cells with NGF or NT 3 , but not brain derived NT factor , NT 4 / 5 , or mutant NGF , resulted in increased release of heparanase activity that was capable of degrading a subpopulation of heparan sulfate molecules . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Neurotrophins ( NTs ) , such as nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , and NT 3 , are required for survival of certain neurons , and thus their clinical use to counteract age and pathology associated neurodegeneration has been suggested , although mechanistic descriptions for NT cell rescue from apoptosis are not definitive . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Cleavage of the yeast pre rRNA at site A ( 2 ) in internal transcribed spacer 1 ( ITS 1 ) requires multiple snoRNP species , whereas cleavage at site A ( 3 ) , located 72 nt 3 ' in ITS 1 , requires Rnase MRP . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
This chapter reviews recent studies on : ( a ) the specificity of NT 3 for proprioceptive sensory neurons in vitro , and the ability of NT 3 to attenuate deficits arising from large fibre sensory neuropathy ; and ( b ) synergistic actions of BDNF and CNTF towards motor neurons in vitro and the ability of BDNF CNTF co treatment to arrest motor neuron disease in the Wobbler mutant mouse . ^^^ The clinical potential of NT 3 in peripheral neuropathies and of BDNF CNTF co treatment in motor neuron disease is highlighted . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Using aggregate cultures derived from human fetal cortical hemispheres , we assessed the effect of BDNF on NPY production varying the following experimental conditions : fetal and culture age ; medium composition ( with and without serum ) , dose and duration of exposure to BDNF , and neurotrophin species tested ( BDNF , NT 4 / 5 , NT 3 or NGF ) . ^^^ Under none of these conditions did BDNF , NT 4 / 5 , NT 3 or NGF induce an increase in NPY production . ^^^ By comparison , using aggregate cultures derived from rat fetal cortices , BDNF and NT 4 / 5 were equipotent in inducing NPY production but NT 3 and NGF were essentially ineffective . ^^^ Western blot analyses of human and rat derived aggregates indicated the presence of full length Trk receptors which are tyrosine phosphorylated in response to either BDNF , NT 4 / 5 or NT 3 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Later in organogenesis , the NTs NT 3 and BDNF colocalized with their respective receptors in differentiated tubules . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
For nerve growth factor ( NGF ) , these are p75NTR ( p 75 ) and p140trk ( referred to as trk or trkA ) , which binds both BDNF and neurotrophin ( NT ) 4 / 5 , and trkC receptor , which binds only NT 3 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The TrkB family of transmembrane proteins serve as receptors for brain derived neurotrophic factor ( BDNF ) , neurotrophin ( NT ) 4 / 5 , and possibly NT 3 , three members of the neurotrophin family of neurotrophic factors . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The vallate gustatory epithelium of nt 3 / mice and of nt 4 / mice appeared normal . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Corticosterone regulates expression of BDNF and trkB but not NT 3 and trkC mRNA in the rat hippocampus . ^^^ NT 3 and trkC mRNA did not show significant changes in any hippocampal region after the various doses of corticosterone . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The role of the 3 ' UTR of the alpha2C AR in mRNA processing was determined by generating new constructs in which the 3 ' UTR was progressively truncated from 552 to 470 , 182 , 143 , or 74 nt 3 ' to the stop codon . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In all three strains , the genome contains ( 5 ' to 3 ' ) , a 40 nt 5 ' untranslated region ( UTR ) , an open reading frame ( ORF ) of 6348 nts that encodes nonstructural proteins , a 123 nt UTR between the two genomic ORFs , a 3189 nt ORF that encodes the structural proteins , and a 62 nt 3 ' UTR . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The 11 bp long intervening sequences are located 1 nt 3 ' to the anticodon as found in other eukaryotic nuclear tRNA genes . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To address this issue , we used an in vitro coculture paradigm in which wild type 3T3 NIH fibroblasts or two different 3T3 cell clones stably expressing trkB T 1 receptors served as monolayer substrates upon which to evaluate the effect of trkB T 1 receptors on nonneuronal cells to influence neurotrophin ( NGF , BDNF , NT 3 , and NT 4 / 5 ) induced neurite outgrowth from retinoic acid ( RA ) treated SY5Y neuroblastoma cells . ^^^ In these experiments , BDNF and NT 4 / 5 induce the strongest neurite outgrowth , followed by NT 3 and then NGF . ^^^ In contrast , NGF induced neurite growth is unaffected and NT 3 associated growth is somewhat reduced . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Once assembled , the surveillance complex is active for searching and recognizing a DSE for approximately 200 nt 3 ' of the stop codon . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In untreated cultures , nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , and neurotrophin ( NT ) 4 / 5 mRNAs were detected by use of reverse transcriptase polymerase chain reaction but NT 3 mRNA was not . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
With endo 8 , however , DNA breakage at the site of the base lesion was equivalent to or less when the gap was positioned 6 nt 3 ' of the lesion than when the gap was 3 nt 3 ' of the lesion . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
BDNF and NT 3 modulate expression and threonine phosphorylation of microtubule associated protein 2 analogues , and alter their distribution in the developing rat cerebral cortex . ^^^ Following ventricular administration of BDNF or NT 3 at embryonic day ( E ) 16 , expression of microtubule associated protein ( MAP ) 2 of 280 kDa was enhanced at E 18 and / or E 20 , and threonine phosphorylation of MAP 2 analogues of 120 and 66 kDa was modulated in different ways . ^^^ NT 3 basically altered the distribution of MAP 2 proteins at E 20 . ^^^ These findings suggest that NT 3 and BDNF play a role in regulating production and phosphorylation of MAP 2 analogues during development of the rat cerebral cortex . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Activation of trkB NT receptors was critical , as glutamate currents were not affected by nerve growth factor or NT 3 , and increased open probability was prevented by the tyrosine kinase inhibitor K 252a . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We show here that adrenal chromaffin cells in the adult rat store neurotrophin ( NT ) 4 , but do not synthesize or store detectable levels of BDNF or NT 3 , respectively . ^^^ NT 3 and cytochrome C were not effective . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
At this site , enhanced BDNF and NT 3 immunoreactivities were evident in the anterior horn cells . ^^^ In mice with a more severe degree of compression , astrocyte like cells showing BDNF immunoreactivity became abundant and axons in the anterior column demonstrated a marked NT 3 immunoreactivity . ^^^ We speculate that the presence of BDNF and NT 3 in neurons and astrocyte like cells is proportionate to the severity of chronic mechanical compression and may contribute to the heterotropic neuronal reserve and survival . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In combination with the neurotrophins ( NT ) nerve growth factor ( NGF ) and NT 3 , which are not neurotrophic for CG neurons , TGF beta significantly promotes CG neuron survival . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The 1 . 8 kb SRalpha transcript has extremely short untranslated regions ( UTRs ) : a 1 2 nt 5 ' and a 9 nt 3 ' UTR with the polyadenylation signal overlapping with the stop codon . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Feeding the mice a Trp deficient diet for 2 weeks significantly decreased in the hippocampal level of NGF but not those of BDNF and NT 3 , as compared with feeding an adequate Trp diet . ^^^ The levels of BDNF in the cerebral cortex were also significantly lower in the mice fed on a Trp deficient diet , while the levels of NGF and NT 3 in the region were not modulated upon feeding of the diet . ^^^ The dietary Trp level had no significant effect on the levels of NGF , BDNF , or NT 3 in the entorhinal cortex nor septum of the mice . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
This 100 kDa NT receptor corresponded to the mature form of the receptor . ^^^ This cDNA encodes a 833 amino acid protein 100 % identical to the recently cloned gp95 / sortilin and was then designated NT 3 receptor gp95 / sortilin . ^^^ The localization of the NT 3 receptor gp95 / sortilin into intracellular vesicles was in agreement with previous results obtained with the purified receptor and with gp95 / sortilin . ^^^ Affinity labeling and binding experiments showed that the 110 kDa NT 3 receptor can be partly transformed into a higher affinity ( Kd = 0 . 3 nM ) 100 kDa protein receptor by cotransfection with furin . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NT 3 modulates NPY expression in primary sensory neurons following peripheral nerve injury . ^^^ This study shows that neurotrophin 3 ( NT 3 ) delivery to the injured nerve influences neuropeptide Y ( NPY ) expression within dorsal root ganglia ( DRG ) neurons . ^^^ NT 3 was delivered by grafting impregnated fibronectin ( 500 ng / ml ; NT group ) in the axotomised sciatic nerve . ^^^ By d 30 , exogenous NT 3 and nerve graft attenuated the upregulation of NPY ( P < 0 . 05 for NT and NG vs FN ) . ^^^ However , NT 3 administration did not influence the expression of CGRP , SP or VIP . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In the type 1 transcript , nucleotide ( nt ) 3 , 745 of MOZ was fused in frame with nt 284 of CBP , whereas in the type 2 transcript , nt 3 , 745 of MOZ was fused out of frame with nt 997 of CBP . ^^^ Direct sequence analysis showed that nt 283 of CBP was fused in frame with nt 3 , 746 of MOZ , that the initiation ATG codon of the CBP gene remained intact , and that there was no mutation or deletion in the part of the CBP gene included in the CBP MOZ transcript . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RESULTS : The pretreatment with anti NGF or anti NT 3 caused a significant 2 3 fold increase in the severity of the experimental inflammation as assessed by a macroscopic damage score , histologic ulceration score , and myeloperoxidase activity in the tissue . ^^^ NGF mRNA was slightly up regulated after NGF immunoneutralization , but NT 3 mRNA was unchanged by NT 3 immunoneutralization . ^^^ CGRP mRNA was not significantly changed after 1 week of colitis by NGF or NT 3 immunoneutralization , whereas beta preprotachykinin mRNA was up regulated after immunoneutralization . ^^^ CONCLUSIONS : These findings suggest a regulatory role for NGF and NT 3 in experimental inflammation of the gut . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Brain derived nerve growth factor ( BDNF ) , NT 3 , NT 4 / 5 and Trks A , B and C exhibited diffuse cytoplasmic and membranous immunostaining patterns in both the ducts and the acini of the exocrine pancreas and the islets of the endocrine pancreas of both normal and PDAC specimens . ^^^ However , when select cell lines were incubated with lower concentrations of NT 3 and BDNF ( 0 , 1 , 5 , 25 and 50 ng / ml ) , invasiveness was significantly stimulated ( p < 0 . 05 ) through the Matrigel matrix . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
A subpopulation of cells in phaeochromocytomas and ganglioneuromas expressed NT 3 , but not other neurotrophins , while in paragangliomas no neurotrophins were detected . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Interestingly , astrocytes of various brain regions show differing patterns of cytokine induced NT expression : NGF is maximally induced in cortex and hippocampus , NT 3 in hippocampus , and NT 4 / 5 in cortex and cerebellum . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Oligonucleotide probes against BDNF and NT 3 mRNA showed only very few faintly positive neurons in both age groups . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The participants preferred primers of 18 24 nucleotides ( nt ) , 39 % 58 % G + C , a melting temperature ( Tm ) of 53 degrees 65 degrees C with a 1 2 nt 3 ' GC clamp , hairpin stems of less than 2 3 bp , homopolymeric runs of less than 4 5 nt , primer dimers of less than 3 4 bp and secondary priming sites of less than 3 4 bp . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The potential advantages of anti bcr abl DNAzymes over RZs include the following : DNAzymes are much less expensive to synthesize ; they are more resistant to serum ; and the anti b2a2 DNAzyme cleaves at a site only 1 nt away from the fusion site , whereas its hammerhead RZ counterpart cleaves this target at a site 8 nt 3 ' to the fusion site , well within abl exon 2 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The 3 . 8 kb TCH transcript has the T . cruzi mini exon appended to a short ( 40 nt ) 5 ' untranslated region ( UTR ) and has a 927 nt 3 ' UTR . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The Cx 30 messenger contains a 148 nt 5 ' UTR and a 480 nt 3 ' UTR . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In addition , the T cells express mRNA and protein specific to nerve growth factor , brain derived neurotrophic factor , NT 3 , and NT 4 / 5 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Specifically identified were amplification products for the following NTs : NGF , BDNF , NT 3 , and NT 4 . ^^^ Immunoassays ( ELISA ) detected BDNF , NT 4 , NGF , and NT 3 in the culture media from HTM cells . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
METHODS : Immunocytochemistry and Western blot analyses were performed using primary antibodies raised against NTs ( nerve growth factor [ NGF ] , brain derived neurotrophic factor [ BDNF ] , NT 3 , and NT 4 / 5 ) and NT receptors ( TrkA , TrkB , TrkC , and p75NTR ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Deletion analysis showed that 3 nt 5 ' of the stem and 1 nt 3 ' of the stem contribute to the binding energy . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
A single change ( G to A ) at nucleotide 3 ( nt 3 ) of the 5 ' untranslated region ( UTR ) of the V 3000 genome resulted in a virus ( V 3043 ) that was avirulent in mice . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We recently reported the molecular identification of a new type of receptor for the neuropeptide neurotensin ( NT ) , the neurotensin receptor 3 ( NTR 3 ) , identical to sortilin , which binds receptor associated protein . ^^^ Biochemical analysis and confocal microscopic imaging clearly indicate that NT is efficiently internalized after binding to NTR 3 , and that despite this internalization , the amount of receptor present on the cell surface is maintained . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In this study , nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , NT 3 and low ( p 75 ) and high affinity ( Trks ) NT receptors were investigated by immunocytochemistry in cytospin centrifuged preparations of human alveolar macrophages . ^^^ Approximately 2 . 5 % alveolar macrophages were immunoreactive for NGF , whereas no macrophages displaying immunoreactivity for BDNF or NT 3 were observed . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In addition , NT 3 and NT 4 sequences contained additional substitutions , including asparagine at position 22 , lysine at position 77 and histidine at position 110 , that were absent in transmitting mother and consensus subtype B sequences . ^^^ Similarly , the vpr sequences of NT 2 contained stop codons and no initiation codons , NT 4 contained a substitution of serine in place of alanine at position 30 , some NT 1 sequences substituted arginine in place of glycine at position 75 , and NT 3 sequences presented a deletion in the C terminus that was absent in transmitting mother and consensus subtype B sequences and is essential for Vpr function . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The R TUUU series consists of four pre tRNAs containing 6 , 8 , 11 and 15 nt 3 ' trailers ending with UUU and no 5 ' leader , while the R TAGC series consists of the same four pre tRNAs as R TUUU except that the terminal sequence is AGC . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Immunoblots of homogenates from human tumors displayed binding of anti nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , and NT 3 antibodies as well as of anti tyrosine specific protein kinase ( Trk ) A , TrkB , and TrkC receptor antibodies , with similar migration characteristics than those displayed by human beta NGF and proteins from rat brain . ^^^ NT 3 and its corresponding TrkC receptor were found in a small number of squamous cell carcinomas within large size tumor cells . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Duplexes of 21 nt siRNAs with 2 nt 3 ' overhangs were the most efficient triggers of sequence specific mRNA degradation . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RESULTS : NGF and BDNF levels were significantly increased in untreated asthmatics compared to the control and the treated group , while NT 3 demonstrated significantly higher levels in treated asthmatics compared to healthy controls . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
An optimized TRS has been designed comprising 88 nt from the N gene TRS , the CS , and 3 nt 3 ' to the M gene CS . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
During a mean 42 month follow up period , clinically overt strokes occurred in 62 subjects [ NT 3 ( 2 . 0 % ) , WCHT 5 ( 2 . 1 % ) , SHT 54 ( 9 . 4 % ) ] , with 14 fatal cases [ NT 1 ( 0 . 7 % ) , WCHT 0 ( 0 % ) , SHT 13 ( 2 . 3 % ) ] . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Ras / MEK but not p 38 signaling mediates NT 3 induced neurite extension from spiral ganglion neurons . ^^^ In other neurons , NT 3 can mediate neuritogenesis and survival via a number of intracellular signal pathways . ^^^ To date , the intracellular transduction pathways involved in the mediation of NT 3 effects have not been investigated in SG neurons . ^^^ To determine whether the activities of NT 3 on SG neurons are dependent on the activation of mitogen activated protein kinase kinases ( MEK ) / extracellular signal regulated kinases ( ERK ) , Ras , and / or p 38 , SG explants from postnatal day 4 rats were cultured with NT 3 and increasing concentrations of the MEK inhibitor U 0126 , the Ras farnesyl transferase inhibitor ( FTI ) 277 , and the p 38 inhibitor SB 203580 . ^^^ A dose dependent decrease of the effects of NT 3 on length and number of processes was observed in the U 0126 and FTI 277 treated SG neurons . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The present work shows that in Escherichia coli the identity of the 6 nt 3 ' of this sequence can be responsible for a 14 fold variation in frameshift frequency . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RESULTS : The 10 to 14 years age group had the lowest total expenditure of $ NT 3 , 055 ( $ US 1 = $ NT 27 . 5 in 1996 ) in 1996 , while the 65 years and over age group had the highest at almost 10 times more than the lowest . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Weak staining of NT 3 and TrkC was noted in the suprabasal layers of corneal and limbal epithelia but was negative in the stratified HLE in nude mice . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Interestingly , these two populations displayed contrasting expression patterns of nerve growth factors and proinflammatory cytokines with higher inflammatory cytokine mRNA levels in alphabeta+ / TCRBV8S2+ cells at all time intervals , whereas the levels of BDNF and NT 3 were higher in alphabeta+ / TCRBV8S2 cells . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Excluding the poly A sequence , the genome consists of 7410 nt divided into a 740 nt 5 ' untranslated region ( 5 ' UTR ) , a 6567 nt long open reading frame coding for a 2189 amino acid ( aa ) polyprotein and a 103 nt 3 ' UTR . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RESULTS : Stimulation with NT 3 lead to significant increases in number and length of neurites , when compared to non stimulated controls . ^^^ Treatment of NT 3 stimulated SG explants resulted in a dose dependent reduction of both parameters , whereas the neurite growth of non stimulated control explants was not significantly influenced by the incubation with Wortmannin . ^^^ CONCLUSIONS : The results demonstrate that neurotrophin induced neurite growth from SG explants can be modulated with the PI3K inhibitor Wortmannin and indicate that PI3K is a key enzyme in the mediation of NT 3 effects in cochlear neurons . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In this study we report the presence of NGF , BDNF and NT 3 in neurons and endocrine cells of mouse , duck and lizard intestine . ^^^ Immunoreactivity to NT 3 was detected : ( a ) in nerve cells of the mouse intestine , ( b ) in endocrine and nerve cells of duck and lizard gut . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The 5 ' terminal 300 nt of the P 1 gene of many isolates was also variable and phylogenetically anomalous , whereas the 380 nt 3 ' terminus of the CP gene was mostly conserved . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
PURPOSE : The purpose of the study was to investigate whether cultured human keratocytes express the neurotensin receptors ( NTR 1 , NTR 2 , and NTR 3 ) , to determine the presence of neurotensin ( NT ) in keratocytes , and to assess the influence of NT on these cells . ^^^ NT , NTR 1 , NTR 2 , and NTR 3 mRNA were detected in human keratocytes by means of reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ CONCLUSIONS : These results indicate that cultured human keratocytes express NTR 1 and NTR 3 and that NT may exert physiological effects on cornea such as regulation of keratocyte proliferation and apoptosis . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We recently showed that the 2 structurally different receptors NTR 1 and NTR 3 were coexpressed in several human cancer cells on which NT exerts proliferative effects . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In most editing sites analyzed in vitro or in vivo , sequences within approximately 30 nucleotides ( nt ) 5 ' and 10 nt 3 ' of the edited C have been found to be required for selection of the correct C editing target and for editing efficiency , but no consensus sequences have been identified . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Physiological and morphological plasticity induced by chronic treatment with NT 3 or NT 4 / 5 in hippocampal slice cultures . ^^^ We have investigated the anatomical and electrophysiological consequences of chronic NT 3 or NT 4 / 5 treatment on established organotypic hippocampal slice cultures maintained in vitro for > 14 days . ^^^ Both NT 3 and NT 4 / 5 increased spontaneous , action potential dependent excitatory synaptic activity ( sEPSCs ) , but only NT 3 increased inhibitory synaptic activity ( sIPSCs ) in CA 3 pyramidal cells . ^^^ Spontaneous bursts of EPSCs were observed after either NT treatment but only NT 3 treated cultures exhibited an increase in spontaneous bursts of IPSCs . ^^^ The frequency of miniature inhibitory postsynaptic currents , but not miniature excitatory postsynaptic currents , was also increased by both NT 3 and NT 4 / 5 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The immunohistochemical occurrence of the neurotrophin ( NT ) proteins nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 4 ( NT 4 ) , and neurotrophin 3 ( NT 3 ) is shown in the pre term newborn , infant , and adult human post mortem cerebellum . ^^^ NGF , NT 4 , and NT 3 positive neuronal perikarya were observed in all specimens examined . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
These cells express aberrant levels of functional p 75 ( NTR ) and TrkC , the putative high affinity receptor for the neurotrophin NT 3 . ^^^ The activity of this purine analog sensitive kinase ( PASK ) was induced by NT 3 in a time dependent fashion , phosphorylating exogenous myelin basic protein ( MBP ) but not denatured enolase . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We found that ( 1 ) trk C , a receptor for neurotrophin 3 ( NT 3 ) , is dominantly expressed in RCEC , but trk B , a receptor for brain derived neurotrophic factor , is dominantly expressed in RAEC ; ( 2 ) NT 3 inhibited the proliferation of RCEC ; and ( 3 ) NT 3 stimulated the production of nitric oxide ( NO ) with increases in protein expression of endothelial NO synthase . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The neurotensin ( NT ) receptor 3 / sortilin ( NTR 3 ) belongs to the new receptor family of VPS10P domain containing receptors . ^^^ The NTR 3 is expressed in all cancer cells on which NT activates cell growth and its cellular location is mainly intracellular within the endoplasmic reticulum and the trans Golgi network . ^^^ The shedding of the membrane NTR 3 leads to a soluble protein able to bind exogenous NT , suggesting a role of this process in the biological activity of the peptide . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The neurotensin ( NT ) receptor , NTS 3 , originally identified as the intracellular sorting protein sortilin , is a member of a recently discovered family of receptors characterized by a single transmembrane domain . ^^^ Many of the areas exhibiting high levels of NTS3 / sortilin ( e . g . , olfactory cortex , medial septum , and periaqueductal gray ) have been documented to contain high concentrations of NT nerve cell bodies and axons , supporting the concept that NTS3 / sortilin may play a role in NT sorting and / or signaling . ^^^ Other areas ( e . g . , hippocampal CA fields , cerebellar cortex , and cranial nerve motor nuclei ) , however , are NT negative , suggesting that NTS3 / sortilin also exerts functions unrelated to NT signaling . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Recently , immunoexpression of NT 3 has been shown to be significantly higher in melanomas than in banal nevi on cryostat tissue . ^^^ METHODS : Since the biologic function of NT 3 is mediated primarily through Trk C , we investigated Trk C immunoexpression on paraffin sections of 10 compound nevi and 63 melanomas . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Immunoreactivities for BDNF , NT 3 , trkB and trkC were preferentially localized in the gray matter , particularly in the anterior horn cells . ^^^ In contrast , the expression levels of BDNF , NT 3 , trkB and trkC were significantly higher at the rostral and caudal sites immediately adjacent to the maximal compression site . ^^^ Our results suggest that overexpression of BDNF , NT 3 , trkB and trkC in motoneuron areas neighboring the site of mechanical compression may represent compensatory changes in response to the compromised neuronal function at the level of compression , and that these proteins possibly contribute to neuronal survival and plasticity . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In this article the expression and anatomic localization of nerve growth factor , brain derived neurotrophic factor , and NT 3 and of corresponding high affinity receptors TrkA , TrkB ( full length and truncated [ TR ] isoforms ) , TrkC , and of the low affinity p 75 receptor , were assessed in surgical samples from adult human lung by reverse transcriptase polymerase chain reaction , Western blot , and immunohistochemistry . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
In all studied species both NGF and NT 3 like immunoreactivity ( IR ) were present in the enteric nervous system , while BDNF like IR was never detected . ^^^ More in particular , both NGF and NT 3 like IR were detected in neurons of small and large intestine , while only NT 3 like IR was also observed in stomach plexuses . ^^^ Furthermore , Western blot analysis revealed the presence of molecules immunoreactive to NGF and NT 3 , which weight were very similar to those of mammalian corresponding neurotrophins . ^^^ These results extend to teleost species the presence and distribution of NGF and NT 3 like IR in the enteric nervous system , suggesting a well preserved presence of these substances in the gut during vertebrate phylogenesis . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RNA duplexes of 21 23 nucleotides ( nts ) , with approximately 2 nt 3 ' overhangs ( called small interfering RNAs or siRNAs ) , have recently been shown to mediate sequence specific inhibition of gene expression in mammalian cells via a post transcriptional gene silencing ( PTGS ) mechanism termed RNA interference ( RNAi ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We determined if neurotrophins 3 and 4 ( NT 3 , NT 4 ) would promote sleep in rabbits . ^^^ Two doses of NT 3 ( 50 and 500 ng ) and three doses of NT 4 ( 50 , 500 and 2000 ng ) were intracerebroventricularly injected at dark onset . ^^^ NT 3 ( 500 ng dose ) and NT 4 ( 500 and 2000 ng doses ) injected at dark onset increased the time spent in non rapid eye movement sleep . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NGF and NT 3 expression in iris was substantially higher compared to CV ; neither target showed any alterations with age . ^^^ Eighteen to 20 h following local treatment of iris and CV with NGF , NT 3 or vehicle , expression of NT receptor protein and mRNA was higher in iris compared with CV projecting neurons from both young and old rats . ^^^ NGF and NT 3 treatment had no effect on NT receptor expression in CV projecting neurons at either age . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
PURPOSE : To determine which of the neurotrophins ( NTs ) nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and neurotrophin 4 / 5 ( NT 4 ) and their receptors ( NTrs ) , TrkA , TrkB , TrkC , and p 75 , are present in the adult rat lacrimal gland . ^^^ RESULTS : RT PCR showed positive bands at the appropriate sizes for NGF , BDNF , NT 3 , and NT 4 , and for the receptors TrkA , TrkB , TrkC , and p 75 . ^^^ Western blot analysis confirmed these results , showing that the lacrimal gland expresses NGF , BDNF , NT 3 , and NT 4 as well as the NTrs TrkA , TrkB , and TrkC and the p 75 protein . ^^^ NGF , BDNF , NT 3 , and NT 4 were localized in the lacrimal gland acini with differing cellular distributions , whereas TrkA , TrkB , and TrkC , were localized in myoepithelial cell and ductal cell membranes . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Incubation with NGF , BDNF , NT 3 , or NT 4 caused a significant increase in the viability and CD 69 expression of isolated eosinophils from bronchoalveolar lavage fluid ( BALF ) but not from peripheral blood , suggesting a unique sensitivity of endobronchial eosinophils to neurotrophins . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Presence of functional TrkC , the putative receptor for the invasion promoting neurotrophin NT 3 , was also expressed in these cells . ^^^ In brain biopsies , we observed increased amounts of NGF and NT 3 in tumor adjacent tissues at the invasion front of human melanoma tumors . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We show that they harbor a 5 ' phosphate and a 3 ' OH and that , remarkably , they contain a 1 4 nt 3 ' overhang . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
For example , murine hair follicles ( HF ) show developmentally and spatio temporally stringently controlled expression of NTs , including nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and NT 4 , and their cognate receptors , tyrosine kinase A C ( TrkA C ) and p 75 neurotrophin receptor ( p75NTR ) . ^^^ NT 3 / TrkC and NGF / TrkA signaling stimulate HF development , while NT 3 , NT 4 and BDNF inhibit the growth ( anagen ) of mature HF by the induction of apoptosis driven HF regression ( catagen ) . p75NTR stimulation inhibits HF development and stimulates catagen . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , and neurotrophin 3 ( NT 3 ) promote the function and / or survival of basal forebrain ( BF ) cholinergic neurons in vivo and in culture . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Using in situ hybridization , mRNA levels of six different trophic factors [ BDNF , neurotrophin ( NT ) 4 / 5 , NGF , NT 3 , aFGF , and bFGF ) were measured at varying time points during the consolidation period after fear conditioning . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Following stimulation with neurotensin ( NT ) , neurotensin / neurotensin receptor 3 complexes were internalized via the endosomal pathway . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
The precursor for the human miR 30 microRNA , which is a 63 nt long RNA hairpin bearing a 2 nt 3 ' overhang , forms a specific complex with Exp 5 and the Ran GTP cofactor . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Using the cigarette price elasticity estimate from 0 . 309 in 2003 , we calculated that if the Health and Welfare Tax were increased by another NT 3 dollars per pack and cigarette producers shifted this increase to the consumers , cigarette consumption would be reduced by 2 . 47 packs / person ( 2 . 2 % ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NTR and had mutation at nt 3 , 889 ( aa 1 052 Val ) in 2B region , these mutations and insertion are molecular basis for cell adaptation ; mutation at nt 4 , 185 ( aa 1 152 Lys ) in 2C region should be attenuated marker ; deletion in 3A region ( nt 5 , 020 5 , 025 ) that caused two amino acids deletion is virus fast growth basis . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : The expression of nerve growth factor , brain derived neurotrophic factor , NT 3 , and NT 4 / 5 , and the receptors tropomyosin receptor kinase A , B , and C , and P 75 was studied in pancreatic cancer cell lines , and normal and pancreatic ductal adenocarcinoma ( PDAC ) tissue samples by quantitative reverse transcription PCR . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Synthetic 21 23 nucleotide ( nt ) small interfering RNA ( siRNA ) with 2 nt 3 ' overhangs was recently found to mediate efficient sequence specific mRNA degradation in mammalian cells . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We also examined the physiological response of AmphiTrk to vertebrate neurotrophins , and found that despite 500 million years of divergence , AmphiTrk transduces signals mediated by NGF , BDNF , NT 3 and NT 4 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Distribution of NGF and NT 3 like protein immunoreactivity in the teleost kidney . ^^^ In both species studied , NGF like and NT 3 like immunoreactivity were present in the kidney with different distribution patterns , while BDNF like immunoreactivity was never detected . ^^^ In goldfish , NGF like and NT 3 like immunoreactivity were identified extensively in cells along part of the arterial branches adjacent to the afferent arterioles . ^^^ In scorpion fish , NGF like and NT 3 like immunoreactive cells were observed both on afferent arterioles and on adjacent secondary branches derived from renal arteries . ^^^ A staining pattern of immunoreactivity similar to that obtained for NGF and NT 3 was detected utilizing S 100 antibody as a juxtaglomerular ( JG ) cell marker . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
At the protein level , brain derived neurotrophic factor and NT 3 were significantly higher in the SF of patients with SpA than in those with OA . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To assess changes in the transcriptional expression level , quantitative real time PCR was carried out and revealed differential mRNA expression of neurotrophins , with marked down regulation of NT 3 mRNA expression and constant levels of nerve growth factor ( NGF ) , brain derived nerve factor ( BDNF ) , and NT 4 / 5 mRNA expression . ^^^ The present data on neurotrophin specific transcriptional down regulation of NT 3 in human COPD indicate a pathophysiological role for neurotrophins in COPD . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
BACKGROUND : NT 3 is a trophic growth factor that promotes the survival of the auditory nerve and may have a potential therapeutic role in slowing neuron loss in progressive deafness , especially as an adjunct to the current cochlear implant . ^^^ This study investigated the loading properties , release kinetics , and implantation potential of alginate beads loaded with NT 3 . ^^^ METHODS : Alginate beads were prepared using an ionic gelation technique and postloaded with NT 3 . ^^^ Release of NT 3 was measured using enzyme linked immunosorbent assay over 5 days . ^^^ RESULTS : Enzyme linked immunosorbent assay studies demonstrated a 98 % to 99 % loading of NT 3 with a slow , partial release over 5 days in Ringer ' s solution . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Northern hybridization showed that NGF , BDNF , and NT 3 mRNAs are expressed in the shaft of the penis . ^^^ However , all the NT receptor mRNAs were expressed in penile sensory neurons of sacral level 1 ( S 1 ) DRG . ( 125 ) 1 NT 3 injected into the shaft of the penis was retrogradely transported into the MPG and S 1 DRG , whereas radioiodinated NGF and BDNF were transported specifically into the S 1 DRG , thus confirming the existence of functional NT receptors in these penile neurons . ^^^ In conclusion , these data suggest that NT 3 may act as a target derived neurotrophic factor for both erection inducing and penile sensory neurons , whereas NGF and BDNF may be more important for the sensory innervation of the penis . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
METHODS : Receptors of bombesin 3 , cholecystokinin ( CCK ) A , CCK B , glucagon like peptide ( GLP ) 1 , melanin concentrating hormone ( MCH ) 1 , orexin 1 , orexin 2 , neuromedin B , neuropeptide Y ( NPY ) 1 and NPY 5 , neurotensin ( NT ) 1 , NT 2 , NT 3 , and leptin receptor long form mRNA in GT 1 7 cells were detected by reversed transcriptase polymerase chain reaction . ^^^ RESULTS : Receptors of bombesin 3 , CCK B , GLP 1 , MCH 1 , orexin 1 , neuromedin B , NPY 1 , NPY 5 , NT 1 , NT 3 , and leptin receptor long form mRNA were expressed in GT 1 7 cells , of which , receptors of GLP 1 , neuromedin B , NPY 1 , and NT 3 were highly expressed . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Increased base pairing , particularly in the region 15 to 25 nt 3 ' of the editing site , significantly increased editing ; disruption of base pairing in this region had little effect . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
METHODS : The immunoreactivity ( IR ) of NT 3 and Trk C was studied in human scalp skin and HFs by immunofluorescent and light microscopic immunohistology . ^^^ RESULTS : Both NT 3 and Trk C showed prominent , yet distinct , IR patterns in human scalp anagen HFs ( anagen 6 ) , whereas they were weakly expressed in catagen and increased again in telogen HFs . ^^^ Within HF compartments , NT 3 IR was prominent in the outer root sheath , inner root sheath , dermal papilla and connective tissue sheath . ^^^ Outside the HF , both NT 3 and Trk C showed prominent IR in the epidermis , sebaceous glands and sweat glands . ^^^ CONCLUSIONS : These observations provide the first indication that NT 3 and Trk C are expressed in human scalp skin and HFs , and suggest that Trk C mediated signalling is involved not only in murine but also in human HF biology . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Abundance of transcripts that encode NT and NT receptors 1 , 2 , and 3 ( NTR 1 , NTR 2 , and NTR 3 ) in total hypothalamic RNA was the quantitative trait measured . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
RESULTS : In hippocampus of suicide subjects compared with control subjects mRNA levels of NGF ( p < . 001 ) , NT 3 ( p < . 001 ) , and NT 4 / 5 ( p < . 001 ) were decreased , whether or not they were expressed as a ratio to cyclophilin or NSE . ^^^ This was accompanied by a decrease in their respective protein levels ( NGF [ p < . 001 ] , NT 3 [ p < . 001 ] , and NT 4 / 5 [ p < . 001 ] ) . ^^^ In PFC , however , mRNA ( p = . 001 ) and protein ( p < . 001 ) levels of NT 4 / 5 and only protein level of NGF ( p < . 001 ) were decreased ; NT 3 levels were unchanged . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To date , three different types of NT receptor ( NTR ) , NTR 1 , NTR 2 and NTR 3 , have been identified only in mammalian species . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
BACKGROUND : Neurotrophins ( NTs ) are a family of growth factors , including nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) and neurotrophin 3 ( NT 3 ) that are involved in inflammation . ^^^ Serum NGF , BDNF and NT 3 were measured by enzyme immunoassay . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Similarities in genome organization and sequence comparisons indicate that these agents should be regarded as members of the genus Foveavirus , their only singular trait being a very large ( > 800 nt ) 3 ' non coding region ( NCR ) , as compared to the ca . 130 180 nt 3 ' NCR observed in other Foveaviruses . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
BACKGROUND : The neurotrophin ( NT ) family , including nerve growth factor NT 3 and brain derived neurotrophic factor ( BDNF ) , has a critical role in the survival , growth , maintenance , and death of central and peripheral neurons . ^^^ The difference in BDNF levels , but not NT 3 , between the coronary sinus and aorta was significantly greater in the unstable angina group compared with the stable effort angina and non coronary artery disease groups . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
However , the pharmacological profile of the adrenal NT 1 11 receptor was different from that of NTR 3 , indicating that this receptor type is not involved in the action of NT 1 11 on corticosteroidogenesis . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
However , several in vitro and in vivo studies of null mutant mice have suggested that neurotrophin 3 ( NT 3 ) also signals through the non preferred TrkB receptor . ^^^ In this study , we have directly addressed the in vivo preference of NT 3 to signal through TrkB or TrkC , by crossing the NT 3 knock in mice ( BDNF ( NT 3 / NT 3 ) mice ) with the TrkB or TrkC null mutant mice . ^^^ We find that TrkB is dispensable , whereas TrkC is required for the neuronal rescue by the NT 3 allele in the brain derived neurotrophic factor and NT 3 dependent cochleovestibular system . ^^^ Our results show that NT 3 maintains survival of cells as well as target innervation only through interactions with TrkC in vivo . ^^^ TrkB and TrkC receptors are thus not functionally redundant for NT 3 , even when coexpressed in neurons of the cochleovestibular system . . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Different types of nerve growth factor and NT 3 treatment were tested before infection ( pretreatment ) , during infection ( transtreatment ) and after withdrawing the viral inoculum ( post treatment ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Small interfering RNA ( siRNA ) , double stranded RNA ( dsRNA ) 21 23 nucleotides ( nt ) long with two nt 3 ' overhangs , has been shown to mediate powerful sequence specific gene silence in mammalian cells through RNA interference ( RNAi ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
We hypothesize that neurotrophins ( NTs ) , nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) and NT 3 , besides their importance in immune system activities , participate in chronic inflammatory disorders and in repair processes . ^^^ Furthermore , BDNF expression in alveolar macrophages and NT 3 expression in the three different BAL immune cell populations investigated were induced during sarcoidosis . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NT 3 was expressed by 58 % of the TC and 38 % of AC carcinoids . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Neurons that survive in the presence of neurotrophin 3 ( NT 3 ) or neurotrophin 4 ( NT 4 ) , including proprioceptive afferents , Merkel end organs and D hair afferents , are also supported by GDNF family ligands neonatally , although at postnatal stages they lose their dependency on GDNF and NTN . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
To determine whether these findings in rodents could be related to humans , we have now studied nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , neurotrophin 4 ( NT 4 ) , glial cell line derived neurotrophic factor ( GDNF ) , and neurturin ( NTN ) mRNA expression patterns in developing human teeth during gestational weeks 6 . 5 11 . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Bone morphogenetic proteins ( BMPs ) 4 and 6 as well as MEK inhibitors PD 98059 and U 0126 potentiate neurotrophin 3 ( NT 3 ) and neurturin ( NTN ) induced neurite outgrowth and survival of peripheral neurons from the E 9 chicken embryo . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Vagal afferent neurons retrogradely transported [ 125I ] neurotrophin 3 ( NT 3 ) , [ 125I ] nerve growth factor ( NGF ) , and [ 125I ] neurotrophin 4 ( NT 4 ) to perikarya in the ipsilateral nodose ganglion , and transganglionically transported [ 125I ] NT 3 , [ 125I ] NGF , and [ 125I ] NT 4 to the central terminal field , the nucleus tractus solitarius ( NTS ) . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Without RA treatment , cells were minimally responsive to neurotrophins ( NTs ) , whereas the sequential application of RA followed by brain derived neurotrophic factor or NT 3 led to a significant increase in neurons displaying mature y a minobutyric acid , acetylcholinesterase , tyrosine hydroxylase , or calbindin phenotypes . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
Neurotrophins ( NTs ) such as BDNF , NT 3 , and NT 4 are important modulators of neuronal function and survival . ^^^
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
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Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA
Interacting proteins: P30990 and Q99523	Pubmed	SVM Score :0.0
NA