| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| A approximately 95 kDa membrane glycoprotein , designated gp95 / sortilin , was purified from human brain extracts by RAP affinity chromatography and cloned in a human cDNA library . ^^^ |
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| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| Binding of the receptor associated protein ( RAP ) to the newly identified putative sorting receptor , sortilin , was analyzed by surface plasmon resonance analysis of recombinant RAP and sortilin domains and compared with binding to megalin and low density lipoprotein receptor related protein ( LRP ) . ^^^ The data show that the RAP binding site in sortilin is localized in the cysteine rich lumenal part homologous to yeast vacuolar protein sorting 10 protein ( Vps10p ) , and the sortilin binding site in RAP is localized in the carboxy terminal domain 3 of the three homologous domains in RAP . ^^^ Whereas sortilin bound only RAP domain 3 , megalin and LRP bound all RAP domains with the functional affinity order : domain 3 > domain 1 > domain II . . ^^^ |
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| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| We recently reported the isolation and sequencing of sortilin , a new putative sorting receptor that binds receptor associated protein ( RAP ) . ^^^ We further demonstrate that the propeptide exhibits pH dependent high affinity binding to fully processed sortilin , that the binding is competed for by RAP and the newly discovered sortilin ligand neurotensin , and that prevention of propeptide cleavage essentially prevents binding of RAP and neurotensin . ^^^ |
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| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin / neurotensin receptor 3 . ^^^ The binding was inhibited by heparin and RAP and by the newly discovered sortilin ligand neurotensin . ^^^ |
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| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99523 and P30533 |
Pubmed |
SVM Score :0.0 |
| NA |
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