| Interacting proteins: Q99523 and P14672 |
Pubmed |
SVM Score :0.0 |
| We show here that , in addition to Glut 4 , the aminopeptidase gp 160 or insulin responsive aminopeptidase ( ' IRAP ' ) , sortilin , and an acutely recycling population of the insulin like growth factor II / mannose 6 phosphate receptor , this compartment includes 60 % of the intracellular population of the transferrin receptor . ^^^ |
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| Interacting proteins: Q99523 and P14672 |
Pubmed |
SVM Score :0.0 |
| Sortilin is a major protein component of Glut 4 containing vesicles . ^^^ We report here by the criteria of the partial protein sequencing and subsequent cDNA cloning that glycoprotein 110 , the last unidentified major protein component of Glut 4 containing vesicles , is sortilin , a novel type 1 receptor like protein recently cloned from human brain ( Petersen , C . ^^^ |
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| Interacting proteins: Q99523 and P14672 |
Pubmed |
SVM Score :0.0 |
| Sortilin is the major 110 kDa protein in GLUT 4 vesicles from adipocytes . ^^^ Subcellular fractionation of rat and 3T3 L 1 adipocytes , together with GLUT 4 vesicle isolation , showed that sortilin was primarily located in the low density microsomes in vesicles containing GLUT 4 . ^^^ |
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| Interacting proteins: Q99523 and P14672 |
Pubmed |
SVM Score :0.0 |
| Sortilin is essential and sufficient for the formation of Glut 4 storage vesicles in 3T3 L 1 adipocytes . ^^^ Forced expression of Glut 4 prior to induction of sortilin leads to rapid degradation of the transporter , whereas overexpression of sortilin increases formation of GSVs and stimulates insulin regulated glucose uptake . ^^^ Finally , we have reconstituted functional GSVs in undifferentiated cells by double transfection of Glut 4 and sortilin . ^^^ |
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| Interacting proteins: Q99523 and P14672 |
Pubmed |
SVM Score :0.0 |
| NA |
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