| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.60003631 |
| All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP Jkappa . mNotch 2 , mNotch 3 and int 3 ( = mNotch 4 ) were shown to interact with RBP Jkappa by the GST fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2 . 0.60003631^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.65546917 |
| First , Notch 3 IC competes with Notch 1 IC for access to RBP Jk and does not activate transcription when positioned close to a promoter . 0.65546917^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| The minimal domain within the Notch 4 ( int 3 ) protein required to inhibit morphogenesis consists of the CBF 1 interaction domain and the cdc 10 repeat domain . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| The NOTCH 4 locus contains a TATA less promoter with two putative transcription initiation sites ( Inr ) , three RBP Jkappa sites , and two GATA recognition sites . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| Notch 4 induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP Jkappa . ^^^ Deletion of the ankyrin repeats , but not the RAM ( RBP Jkappa associated module ) domain or C terminal region ( CT ) , abrogated the inhibition of fibroblast growth factor 2 ( FGF 2 ) and vascular endothelial growth factor ( VEGF ) induced sprouting by Notch 4 , whereas the ankyrin repeats alone partially blocked sprouting . ^^^ Thus , Notch 4 induced inhibition of sprouting requires the ankyrin repeats and appears to involve RBP Jkappa dependent and independent signaling . . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| We determined that Notch 3 ' s regulation of c FLIP was independent of the activity of the classical DNA binding protein , RBP Jk , but dependent upon cross talk activation of the ERK / MAPK pathway . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| Moreover , we established that HRT 1 and HRT 2 are direct downstream target genes of Notch 3 signaling in VSMCs and determined that the activity of the nuclear protein RBP Jk is essential for their regulation . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| CADASIL associated Notch 3 mutations have differential effects both on ligand binding and ligand induced Notch 3 receptor signaling through RBP Jk . ^^^ In this study , we investigated the consequences of three pathogenic Notch 3 mutations on the biological activity of the receptor by analyzing ligand ( Delta / Jagged ) induced signaling via RBP Jk . ^^^ Taken together , these data indicate that CADASIL associated Notch 3 mutations differ with respect to their consequences both on ligand binding and ligand induced signaling through RBP Jk , whereas they have similar effects on receptor maturation . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| We show here that a binding site for the Notch effector CBF 1 is essential for all Blbp transcription in radial glia , and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch 1 and Notch 3 receptors . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| Overexpression of constitutively active Notch intracellular ( IC ) receptors ( Notch 1 IC and Notch 3 IC ) resulted in a significant downregulation of alpha actin , calponin , myosin , and smoothelin expression , an effect that was significantly attenuated after inhibition of Notch mediated , CBF 1 / RBP Jkappa dependent signaling by coexpression of RPMS 1 ( Epstein Barr virus encoded gene product ) and selective knockdown of basic helix loop helix factors [ hairy enhancer of split ( HES ) gene and Hes related transcription ( Hrt ) factors Hrt 1 , Hrt 2 , and Hrt 3 ] using targeted small interfering RNA . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To understand the functional consequences of a recurrent CADASIL mutation on furin processing , cell surface expression , ligand binding , and activation of a downstream effector CBF 1 by the Notch 3 receptor . ^^^ |
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| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99466 and Q06330 |
Pubmed |
SVM Score :0.0 |
| NA |
|