| Effects of BAG 1 and proHB EGF co expression were demonstrated in cell adhesion and cell survival assays and in quantitative assays of regulated secretion of soluble HB EGF . ^^^ In addition , because effects of BAG 1 on regulated secretion of soluble HB EGF were also identified , this interaction has the potential to alter the signaling capabilities of both the membrane anchored and the diffusible forms of the growth factor . . ^^^ BAG 1 is a novel cytoplasmic binding partner of the membrane form of heparin binding EGF like growth factor : a unique role for proHB EGF in cell survival regulation . ^^^ |