| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.53206759 |
| Each member of the group formed by BTC , heparin binding EGF ( HB EGF ) and epiregulin ( EP ) can interact with both the EGF receptor ( EGFR ) and heregulin receptors ( ErbB 3 and ErbB 4 ) , and are hence called `` bispecific ' ' ligands . 0.53206759^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Among the EGF agonists , HB EGF induced a low level of ErbB 4 tyrosine phosphorylation , while BTC was as efficient as NDF in activating ErbB 4 . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Down regulation of cell surface ErbB 1 or ErbB 2 by intracellular expression of specific antibodies has allowed us to delineate the role of these receptors during signaling elicited by : EGF and heparin binding EGF ( HB EGF ) , ligands of ErbB 1 ; betacellulin ( BTC ) , a ligand of ErbB 1 and ErbB 4 ; and neu differentiation factor ( NDF ) , a ligand of ErbB 3 and ErbB 4 . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| It is demonstrated that HB EGF is not only a ligand for HER 1 , as previously reported , but for HER 4 as well . ^^^ HB EGF binds to NIH 3T3 cells overexpressing either HER 1 or HER 4 alone , but not HER 2 or HER 3 alone . ^^^ The ability of HB EGF to bind to two different receptors is in contrast to EGF which binds to HER 1 , but not to HER 4 , and heregulin beta 1 which binds to HER 4 , but not to HER 1 . ^^^ Besides binding , HB EGF activates HER 4 . ^^^ On the other hand , HB EGF is not a mitogen for cells expressing HER 4 , in contrast to its ability to stimulate both chemotaxis and proliferation in cells expressing HER 1 . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| HB EGF activates two EGF receptor subtypes , HER 1 and HER 4 and binds to cell surface HSPG . ^^^ |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Finally , treatment of E 5 expressing cells with HB EGF shows no increased phosphorylation of the ErbB 4 receptor , suggesting a specific effect of E 5 on the activation of the different members of the EGFR family . . ^^^ |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Heparin binding epidermal growth factor like growth factor ( HB EGF ) is an EGF family member expressed by numerous cell types that binds to EGF receptor 1 ( HER 1 ) or 4 ( HER 4 ) inducing mitogenic and / or chemotactic activities . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| TGF ( & agr ; ) or HB EGF binds to EGF receptor ( ErbB 1 ) , while HB EGF , in addition , binds to ErbB 4 . ^^^ ErbB 4 is a candidate for being an HB EGF responsive receptor since RT PCR analysis demonstrated that day 4 mouse blastocysts express two different erbB 4 isoforms and immunostaining with anti ErbB 4 antibodies confirmed that ErbB 4 protein is expressed at the apical surface of the trophectoderm cells . ^^^ It is concluded that ( 1 ) HB EGF interacts with the blastocyst cell surface via high affinity receptors other than ErbB 1 , ( 2 ) the HB EGF interaction with high affinity blastocysts receptors is regulated by heparan sulfate , and ( 3 ) ErbB 4 is a candidate for being a high affinity receptor for HB EGF on the surface of implantation competent blastocysts . . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Heparin binding epidermal growth factor ( HB EGF ) interacts with both EGF R and a related receptor , ErbB 4 , whereas transforming growth factor alpha ( TGFalpha ) interacts only with EGF R . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Heparin binding epidermal growth factor like growth factor ( HB EGF ) , an activating ligand for the epidermal growth factor receptor ( ErbB 1 ) tyrosine kinase and at least one isoform of the ErbB 4 receptor tyrosine kinase , is synthesized by the smooth muscle of the human bladder wall . ^^^ Human and mouse bladder SMC in vivo and cultured human bladder SMC expressed the primary HB EGF receptor , ErbB 1 , but not mRNA for the secondary HB EGF receptor , ErbB 4 , thereby identifying ErbB 1 as the cognate HB EGF receptor in the bladder wall . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| HB EGF both induced intracellular Ca2+ signaling and accelerated trophoblast development to an adhesion competent stage , but only late on gestation day 4 after ErbB 4 , a receptor for HB EGF , translocated from the cytoplasm to the apical surface of trophoblast cells . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The HB EGF precursor within this complex is processed by MMP 7 , and the resulting mature HB EGF engages and activates its receptor , ErbB 4 , leading to , among other events , cell survival . ^^^ In both uterine and mammary epithelia of these mice , MMP 7 localization is altered and pro HB EGF processing as well as ErbB 4 activation are decreased . ^^^ Our observations provide a mechanism for the assembly and function of a cell surface complex composed of CD44HSPG , MMP 7 , HB EGF , and ErbB 4 that may play an important role in the regulation of physiological tissue remodeling . . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| HB EGF induced phosphorylation of the EGF receptor ( EGFR ) with maximum phosphorylation at 0 . 5 to 1 minute , whereas erbB 4 , the other receptor to which HB EGF binds , was not activated on HB EGF stimulation . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| HER 4 , one of the two cognate receptors for HB EGF , was found translocated into the nucleus . ^^^ |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| We further observed that HB EGF induces autophosphorylation of ErbB 1 and ErbB 4 in the uterus and blastocyst . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Induction of DNA synthesis by HB EGF and its modulation by TNFalpha in endometrial stromal cells are mediated by the EGF receptor and not the HB EGF receptor ErbB 4 . ^^^ |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The heparin binding epidermal growth factor ( EGF ) like growth factor ( HB EGF ) is a member of the EGF family of growth factors that binds to and activates the EGF receptor ( EGFR ) and the related receptor tyrosine kinase , ErbB 4 . ^^^ HB EGF induced tyrosine phosphorylation of ErbB 2 and ErbB 4 , and to a lesser degree , of EGFR in cardiac myocytes . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Heparin binding epidermal growth factor ( HB EGF ) and betacellulin ( BTC ) are activating ligands for EGF receptor ( EGFR / ErbB1 ) and ErbB 4 . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Endothelial derived heparin binding EGF like growth factor ( HB EGF ) was shown to mediate this process by signaling via ErbB 1 and ErbB 2 receptors in SMCs . 1 ) Analysis of ErbB ligands demonstrated that primary ECs expressed only HB EGF and neuregulin 1 . 2 ) Primary SMCs expressed ErbB 1 and ErbB 2 , but not ErbB 3 or ErbB 4 . 3 ) Consistent with their known receptor specificities , recombinant HB EGF , but not neuregulin 1 , stimulated tyrosine phosphorylation of ErbB 1 and ErbB 2 and migration in SMCs . 4 ) Neutralization of HB EGF or inhibition of ErbB 1 or ErbB 2 blocked 70 90 % of the potential of ECs to stimulate SMC migration . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Six of 9 myeloma cell lines and 9 of 9 purified primary myeloma cells expressed ErbB 1 or ErbB 4 genes coding for HB EGF receptor . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| We characterized the expression of epidermal growth factor ( EGF ) like growth factors ( EGF , transforming growth factor alpha ( TGF alpha ) , heparin binding EGF like growth factor ( HB EGF ) , betacellulin ( BTC ) , amphiregulin ( APR ) , epiregulin ( EPR ) and neuregulin ( NRG ) 1 ) and erbB receptors ( EGF receptor ( EGFR ) , erbB2 / neu , erbB 3 and erbB 4 ) in the vaginae of mice treated either neonatally ( 0 4 day ) or as adults ( 55 59 day ) with estrogens . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Developing extravillous trophoblasts accumulate heparin binding EGF like growth factor ( HB EGF ) , a multifunctional cytokine , which binds HER 1 and HER 4 of the human EGF receptor ( HER / ErbB ) family . ^^^ Function blocking antibodies against EGF family members reduced basal cell motility and antibody inhibition of either HER 1 or HER 4 ligation prevented HB EGF induced integrin switching . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , within myotome pairs , the expression of HB EGF is stronger on the left side of the body , whilst cognate receptors , ErbB 1 and ErbB 4 , are symmetrically expressed in left and right somite pairs . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| In this study , we identify factors that modulate expression of HB EGF , EGFR , and ErbB 4 in endometrial stromal cells in vitro . ^^^ We demonstrate that levels of sol and tm HB EGF , EGFR , and ErbB 4 are increased by cAMP , a potent inducer of decidualization of the endometrial stroma . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Western analysis assessed kidney expression of amphiregulin ( AR ) , epidermal growth factor ( EGF ) , heparin binding EGF ( HB EGF ) , and their receptors , EGFR and ErbB 4 . ^^^ AR , EGF , HB EGF , EGFR , and ErbB 4 were abnormally expressed to an equal degree in kidneys of mice with versus without TGF alpha . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative RT PCR analysis revealed that HB EGF and HER 1 mRNA levels were high in the mid luteal phase , whereas HER 4 mRNA expression was high in the early luteal phase . ^^^ CONCLUSIONS : HB EGF may play a vital role in regulating luteal growth in a juxtacrine manner and through activating HER 4 signalling . . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Heparin binding EGF like growth factor ( HB EGF ) is a member of the EGF family of growth factors that binds to and activates the EGF receptor ( EGFR ) and ERBB 4 . ^^^ |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| At 2 % O ( 2 ) , signaling via HER 1 or HER 4 , known HBEGF receptors , is required for both HBEGF upregulation and protection against apoptosis . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the effect of mifepristone on heparin binding epidermal growth factor ( HB EGF ) and its receptors HER 1 and HER 4 in the fallopian tube and in the endometrium . ^^^ CONCLUSION ( S ) : Treatment with mifepristone has a limited effect on HB EGF and its receptors in the fallopian tube , while the increase in HER 1 and HER 4 in the endometrium probably reflects defective endometrial maturation . . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Six genes were over expressed ( ERBB 2 , TGFA , HB EGF , AREG , EREG and EPGN ) , 3 were under expressed ( ERBB 1 , ERBB 4 and NRG 4 ) and 2 were over or under expressed ( ERBB 3 and BTC ) . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The heparin binding EGF like growth factor ( HB EGF ) is a member of the EGF family of growth factors that binds to and activates the EGF receptor ( EGFR / ErbB1 ) and ErbB 4 . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Prolactin and the ErbB 4 ligand HB EGF each induced STAT5A activation , expression of lactogenic differentiation markers , and lumen formation in three dimensional Matrigel cultures in HC 11 cells . ^^^ Without treating HC 11 cells with prolactin or HB EGF , s 80 ( HER 4 ) ( expressed from a cDNA construct ) localized to the nucleus , activated STAT5A , and induced three dimensional lumen formation . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Human epidermal growth factor receptor 4 ( HER 4 ) is a member of the epidermal growth factor ( EGF ) receptor subfamily of receptor tyrosine kinases that is activated by neuregulins ( NRG ) , betacellulin ( BTC ) , and heparin binding EGF like growth factor . ^^^ |
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| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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