| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.59638768 |
| CD 9 associates with a diphtheria toxin receptor ( DTR ) that is identical to the membrane anchored form of heparin binding EGF like growth factor . 0.59638768^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.72533543 |
| CD 9 antigen interacts with heparin binding EGF like growth factor through its heparin binding domain . 0.72533543^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| When diphtheria toxin receptor was passed through an affinity column made with this antibody , the receptor was trapped only in the presence of DRAP 27 . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| CD 9 appears to play a role in platelet activation and to enhance sensitivity of cells to diphtheria toxin through its association with the diphtheria toxin receptor . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| DRAP 27 , the monkey homolog of human CD 9 antigen ( DRAP27 / CD9 ) and diphtheria toxin receptor ( DTR ) were expressed in mouse L cells . ^^^ DRAP 27 , the monkey homolog of human CD 9 antigen ( DRAP27 / CD9 ) and diphtheria toxin receptor ( DTR ) were expressed in mouse L cells . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Hypersensitivity to diphtheria toxin by mouse cells expressing both diphtheria toxin receptor and CD 9 antigen . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Although the membrane anchored form of heparin binding epidermal growth factor like growth factor ( proHB EGF ) , which is identical to the diphtheria toxin receptor , forms a complex with CD 9 in some human and monkey cell lines , proHB EGF was not detected in myelin immunocytochemically . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Cell surface monkey CD 9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| CD 9 associates with diphtheria toxin receptor ( DTR ) , which is identical to the membrane anchored form of heparin binding EGF like growth factor ( proHB EGF ) . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Membrane anchored heparin binding EGF like growth factor ( HB EGF ) and diphtheria toxin receptor associated protein ( DRAP 27 ) / CD9 form a complex with integrin alpha 3 beta 1 at cell cell contact sites . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Transfection of human HB EGF cDNA into mouse LC cells , L cells stably expressing DRAP 27 , conferred sensitivity to DT , but transfection of mouse HB EGF cDNA did not . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| The CD 9 antigen is associated with surface proteins such as VLA integrins or HB EGF precursor . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that CD 9 functions as an up regulator of membrane anchored heparin binding EGF like growth factor ( proHB EGF ) activity , which is a potent mitogen as well as a soluble HB EGF . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| We have previously determined that HB EGF is expressed in macrophages and SMCs of human atherosclerotic lesions and that its membrane anchored precursor , proHB EGF , also has a juxtacrine mitogenic activity which is markedly enhanced by CD 9 , a surface marker of lymphohaemopoietic cells . ^^^ HB EGF and CD 9 at both the mRNA and the protein level were up regulated after differentiation into macrophages , and further expression of HB EGF was induced by the addition of OxLDL or lysophosphatidylcholine . ^^^ Juxtacrine induction by formalin fixed growth was suppressed to control levels by an inhibitor of HB EGF and was partially decreased by anti CD 9 antibodies . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of four tetraspans , CD 9 , CD 53 , CD 81 , and CD 82 , suggests a common role in costimulation , cell adhesion , and migration : only CD 9 upregulates HB EGF activity . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| ProHB EGF ( the membrane anchored form of HB EGF ) has also been demonstrated to possess a mitogenic activity , which is approximately 30 fold increased when coexpressed with CD 9 in mouse L cells . ^^^ The juxtacrine growth activities of human aortic SMCs were inhibited in vitro by adding neutralization antibodies for CD 9 or adding the specific inhibitor of HB EGF . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Osmotically relevant membrane signaling complex : association between HB EGF , beta ( 1 ) integrin , and CD 9 in mTAL . ^^^ The integral membrane proteins cluster of differentiation 9 ( CD 9 ) , beta ( 1 ) integrin , and heparin binding epidermal growth factor like ( HB EGF ) exist in association in many cell lines and are linked to intracellular signaling mechanisms . ^^^ Immunohistochemistry and immunoprecipitation studies show that CD 9 , HB EGF , and beta ( 1 ) integrin are coexpressed and physically associated in medullary thick ascending limbs ( mTAL ) , nephron segments that are normally exposed to high and variable extracellular osmolality . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Juxtacrine activity of proHB EGF ( the membrane anchored form of HB EGF ) has been shown to be significantly potentiated when it is coexpressed with CD 9 in vitro . ^^^ HB EGF gene expression and protein production in human gastric cancers was investigated , and EGF receptor and CD 9 expressions were also evaluated . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| They also overexpressed CD 9 , a tetraspanin that binds to the heparin binding domain of HB EGF and is critical for promoting ErbB 1 activation by HB EGF . ^^^ The XG 6 and XG 13 myeloma cells that were not significantly sensitive to HB EGF antagonists , poorly expressed HB EGF , ErbB 1 and CD 9 genes or proteins . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| GPCR activation enhances the association of KUZ and its substrate HB EGF with tetraspanin CD 9 . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Importance of the major extracellular domain of CD 9 and the epidermal growth factor ( EGF ) like domain of heparin binding EGF like growth factor for up regulation of binding and activity . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| Human and monkey CD 9 upregulate the diphtheria toxin ( DT ) binding activity of human heparin binding EGF like growth factor , while chick CD 9 lacks the ability to upregulate the DT binding activity . ^^^ |
|
| Interacting proteins: Q99075 and P21926 |
Pubmed |
SVM Score :0.0 |
| NA |
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