| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| Heparitinase / chlorate , which digests the heparan sulfate proteoglycan of the endothelial cell surface , restored both t PA and PAI 1 mRNA levels in response to HB EGF in a manner similar to that by EGF . ^^^ |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| These results suggested that adhesion between blastocysts and cells synthesizing HB EGF TM was mediated via interaction with both blastocyst EGFR and heparan sulfate proteoglycan ( HSPG ) . ^^^ |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| Binding studies with three HS binding growth factors , basic fibroblast growth factor ( b FGF ) , heparin binding epidermal growth factor ( HB EGF ) , and amphiregulin , showed that the HS modified CD 44 isoforms are able to bind to b FGF and HB EGF , but not AR . b FGF and HB EGF binding to HS modified CD 44 was eliminated by pretreating the protein with heparitinase or by blocking with free heparin . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| We investigated the mitogenic effects of heparin binding epidermal growth factor like growth factor ( HB EGF ) in vascular smooth muscle cells ( SMCs ) obtained from rats with streptozotocin ( STZ ) induced diabetes and evaluated the role of heparan sulfate proteoglycan ( HSPG ) in inducing these effects . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| Finally , a synthetic peptide derived from the 21 residue stretch was found to compete with HB EGF for binding to Chinese hamster ovary cells , suggesting that the heparin binding sequences in HB EGF may also mediate the interaction of this factor with cell surface heparan sulfate proteoglycan . . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| Heparin binding EGF like growth factor ( HB EGF ) , but not EGF , binds to cell surface heparan sulfate proteoglycan ( HSPG ) . ^^^ |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that CD 44 heparan sulfate proteoglycan ( CD44HSPG ) recruits proteolytically active matrix metalloproteinase 7 ( matrilysin , MMP 7 ) and heparin binding epidermal growth factor precursor ( pro HB EGF ) to form a complex on the surface of tumor cell lines , postpartum uterine and lactating mammary gland epithelium , and uterine smooth muscle . ^^^ |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| For in vitro studies of tubulogenesis , a rat renal epithelial cell line ( NRK52E ) stably transfected with proHB EGF ( NRKproHB EGF ) was treated with TPA for 30 minutes , washed with 2 mol / L NaCl to remove soluble HB EGF trapped by cell surface heparan sulfate proteoglycan and replated onto plastic dishes in the absence of fetal calf serum . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrate that brief treatment of matrix laden rat pulmonary fibroblast cultures with pancreatic elastase results in the release of soluble heparin binding epidermal growth factor like growth factor ( HB EGF ) concomitant with a decrease in HB EGF binding to both heparan sulfate proteoglycan and receptor sites on the cells . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| A literature search was undertaken using PubMed and MEDLINE search engines , using the keywords p 53 , p 21 , p 16 , p 27 , SMAD 4 , K ras , cyclin D 1 , Bax , Bcl 2 , EGFR , EGF , c erbB 2 , HB EGF , TGFbeta , FGF , MMP , uPA , cathepsin , heparanase , E cadherin , laminins , integrins , TMSF , CD 44 , cytokines , angiogenesis , VEGF , IL 8 , beta catenin , DNA microarray , and gene profiling . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| Many of the up regulated genes including the hyaluron receptor CD 44 , vasoconstrictor endothelin 1 , smooth muscle growth factor heparin binding EGF like growth factor , and fatty acid binding protein 4 had been previously described as linked to the development of atherosclerosis and other chronic inflammatory diseases . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| These genes can influence neuronal survival by affecting diverse pathways such as growth factor signal transduction ( CD 44 , DTR , DUSP 6 , EPS 8 , IGFBP 3 ) , DNA repair and transcription ( FOXJ 1 ) , metabolic homeostasis ( RASA 1 , SHMT 2 ) , cytoskeletal stability ( MSN , MAPT ) and cholesterol biosynthesis ( FDFT 1 , FDPS ) . . ^^^ |
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| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| PATIENTS AND METHODS : Twenty nine patients with advanced , progressive MTC , as documented by short serum calcitonin doubling times ( Ct DTs ) , received an anti carcinoembryonic antigen ( CEA ) / anti diethylenetriamine pentaacetic acid ( DTPA ) indium BsMAb , followed 4 days later by a 131I labeled bivalent hapten . ^^^ |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99075 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|