| Interacting proteins: Q99075 and P09237 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that CD 44 heparan sulfate proteoglycan ( CD44HSPG ) recruits proteolytically active matrix metalloproteinase 7 ( matrilysin , MMP 7 ) and heparin binding epidermal growth factor precursor ( pro HB EGF ) to form a complex on the surface of tumor cell lines , postpartum uterine and lactating mammary gland epithelium , and uterine smooth muscle . ^^^ The HB EGF precursor within this complex is processed by MMP 7 , and the resulting mature HB EGF engages and activates its receptor , ErbB 4 , leading to , among other events , cell survival . ^^^ In both uterine and mammary epithelia of these mice , MMP 7 localization is altered and pro HB EGF processing as well as ErbB 4 activation are decreased . ^^^ Our observations provide a mechanism for the assembly and function of a cell surface complex composed of CD44HSPG , MMP 7 , HB EGF , and ErbB 4 that may play an important role in the regulation of physiological tissue remodeling . . ^^^ |
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| Interacting proteins: Q99075 and P09237 |
Pubmed |
SVM Score :0.0 |
| We identified MMP 7 as a major HB EGF sheddase in rat mesenteric arteries and alpha ( 1b ) adrenoceptors , angiotensin receptors , and hypertension stimulated MMP 7 activity . ^^^ These findings suggest a previously unknown mechanism of vasoregulation whereby agonists of certain GPCRs ( such as adrenoceptors and angiotensin receptors ) activate MMPs ( such as MMP 7 ) that shed EGFR ligands ( such as HB EGF ) , which then activate the EGFR , thereby promoting vasoconstriction as well as growth . ^^^ |
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| Interacting proteins: Q99075 and P09237 |
Pubmed |
SVM Score :0.0 |
| Heparin binding epidermal growth factor precursor ( proHB EGF ) is cleaved by matrilysin into mature HB EGF , which promotes cellular proliferation . ^^^ |
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