| Interacting proteins: O43847 and Q99075 |
Pubmed |
SVM Score :0.77236232 |
| At the cell surface , NRDc binds heparin binding epidermal growth factor like growth factor ( HB EGF ) and enhances HB EGF induced cell migration . 0.77236232^^^ Furthermore , we show that HB EGF not only binds to NRDc but also potently inhibits its enzymic activity . 0.50697455^^^ |
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| Interacting proteins: O43847 and Q99075 |
Pubmed |
SVM Score :0.0 |
| Since for those processes its enzymatic activity is not required , it is now evident that nardilysin fulfills at least two distinct functions , i . e . an HB EGF modulator and a peptidase . . ^^^ |
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| Interacting proteins: O43847 and Q99075 |
Pubmed |
SVM Score :0.0 |
| HB EGF ( 5 100 ng / ml ) stimulated by approximately 80 % the incorporation of bromodeoxyuridine ( BrdU ) into cultured cells that expressed the HB EGF receptors epidermal growth factor receptor ( EGFR ) / avian erythroblastic leukemia viral oncogene homolog 1 ( ErbB 1 ) and N arginine dibasic convertase ( NRDc ) . ^^^ Intracerebroventricular administration of HB EGF in adult rats increased BrdU labeling in the subventricular zone and in the subgranular zone of dentate gyrus , where EGFR / ErbB1 and NRDc were also expressed and where ischemia induced neurogenesis is observed . ^^^ We conclude that HB EGF stimulates neurogenesis in proliferative zones of the adult brain that are also affected in ischemia and that it does so by interacting with EGFR / ErbB1 and possibly NRDc . ^^^ |
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| Interacting proteins: O43847 and Q99075 |
Pubmed |
SVM Score :0.0 |
| While NRDc binds heparin binding epidermal growth factor ( HB EGF ) at the cell surface and potentiates its physiological effect , HB EGF potently inhibits the NRDc ' s activity . ^^^ |
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