| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| METHODS : The present study examined : ( 1 ) the time course and dose response functions for the effects of human / rat ( h / r ) CRF ( 0 . 02 0 . 6 nmol , ICV ( intracerebroventricular ) ) on ASR in two inbred strains of mice ; ( 2 ) the effects of the CRF 1 receptor antagonist NBI 30775 ( 20 mg / kg , intraperitoneal ) and the CRF 2 receptor antagonist Antisauvagine 30 ( 1 10 nmol , ICV ) on CRF potentiated ASR and ( 3 ) the effects of the CRF 2 receptor agonist urocortin 2 ( 0 . 2 6 nmol , ICV ) on ASR in mice . ^^^ The selective CRF 2 receptor agonist urocortin 2 increased ASR ( 1 and 2 nmol ) , albeit with less efficacy than the non selective CRF receptor agonist h / r CRF . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) , a CRF related peptide that selectively binds CRF 2 receptors , was recently identified and recognized for its central anorectic properties . ^^^ Urocortin 2 ( Ucn 2 ) , a CRF related peptide that selectively binds CRF 2 receptors , was recently identified and recognized for its central anorectic properties . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Behavioral and neuroendocrine effects of the selective CRF 2 receptor agonists urocortin 2 and urocortin 3 . ^^^ We compared the in vivo efficacy of two selective CRF 2 agonists , mouse urocortin 2 ( mUcn 2 ) and human urocortin 3 ( hUcn 3 ) , using food intake , anxious behavior , or ACTH release in CD 1 or Balb / c mice as indices of biological stress responses . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Corticotropin releasing factor ( CRF ) and the CRF like peptide urocortin 1 ( UcnI ) exert their activity through two different CRF receptors , CRF 1 and CRF 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) and Ucn 3 are new members of the corticotropin releasing factor ( CRF ) family and bind selectively to the CRF type 2 receptor ( CRF 2 ) . ^^^ These results suggest that the CRF 2 receptor is involved in motor suppressive effects as well as anxiolytic and anorectic effects of Ucn 2 and Ucn 3 . . ^^^ Urocortin 2 ( Ucn 2 ) and Ucn 3 are new members of the corticotropin releasing factor ( CRF ) family and bind selectively to the CRF type 2 receptor ( CRF 2 ) . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| In addition to urocortin ( Ucn 1 ) , Ucn 2 and Ucn 3 were identified as endogenous ligands for corticotropin releasing factor type 2 receptor ( CRF 2 receptor ) . ^^^ Therefore , it is thought that Ucn 2 may modulate CRF and vasopressin synthesis in the PVN in a paracrine or autocrine fashion through PVN CRF 2 receptor . ^^^ The systemic administration of Ucn 2 decreases mean arterial pressure ( arterial vascular tone ) and causes tachycardia via vascular CRF 2 receptor in rats , similar to the effects of Ucn 1 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 binds with high affinity to CRF type 1 ( CRF 1 ) and type 2 ( CRF 2 ) receptors while Ucn 2 and Ucn 3 are selective CRF 2 ligands . ^^^ In addition , Ucn 2 showed visceral anti nociceptive activity associated with the selective activation of CRF 2 receptors . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The intra DRN administration of the selective CRF 2 agonist urocortin 2 ( Ucn 2 ) dose dependently increased 5 HT efflux in the basolateral amygdala , a projection region of the DRN . ^^^ Both of these effects of Ucn 2 were completely blocked by intra DRN antisauvagine 30 ( ASV 30 ) , a relatively selective CRF 2 antagonist . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| CRF ( 0 . 1 4 nmol ) , urocortin 2 ( a selective CRF 2 receptor agonist 2 . 5 100 pmol ) , or saline vehicle was injected intracisternally , and changes in hepatic circulation were observed for 120 minutes . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Ucn 2 is expressed in the adrenal medulla , and its receptor , CRF 2 receptor , is also expressed in the adrenal gland . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| To determine if CRF 2 receptor activation has effects on serotonergic neurons in the DR in conscious behaving rats , we gave intracerebroventricular ( icv ) injections of the selective CRF 2 receptor agonist urocortin 2 ( 0 , 0 . 01 , 0 . 1 , or 1 . 0 mug in 2 microl saline ) to adult male Wistar rats and quantified c Fos expression in topographically organized subpopulations of serotonergic neurons within the DR . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Selective activation of the CRF 2 receptor by stresscopin related peptide ( SRP ; i . p . 25 microg kg 1 ) reduced the distension induced visceromotor and behavioural response . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| In the gastrointestinal tract , these compounds open new therapeutic options in the treatment of lower GI inflammatory diseases associated to CRF , such as the chronic inflammatory bowel syndromes , irritable bowel disease and ulcerative colitis while Ucn , Ucn 1 , Ucn 2 or synthetic non peptide CRF 2 agonists may be useful in the treatment of upper GI inflammatory diseases . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| To determine if the CRF 2 receptor agonist urocortin 2 ( Ucn 2 ) increases c Fos expression in rat DR serotonergic neurons via actions on CRF 2 receptors , we gave intracerebroventricular ( icv ) injections of mouse Ucn 2 after icv injections of either saline or the CRF 2 receptor antagonist antisauvagine 30 ( ASV 30 ) . ^^^ Mouse Ucn 2 had no effect on c Fos expression within the median raphe nucleus , consistent with the hypothesis that Ucn 2 has specific actions on an anatomically and functionally distinct subset of serotonergic neurons via activation of CRF 2 receptors . ^^^ These findings are also consistent with the hypothesis that Ucn 2 , or another CRF related neuropeptide acting at CRF 2 receptors , modulates physiological and behavioral responses to stress related stimuli via actions on a specific subset of serotonergic neurons within the dorsal raphe nucleus . . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The selective CRF 2 agonist , human urocortin 2 ( hUcn 2 , at 10 and 20 microg / kg ) , injected intravenous after the first distension , prevented sensitisation and reduced the second response by 8 ( 1 ) % and 30 ( 5 ) % ( p < 0 . 05 ) compared with the first response , respectively . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The selective CRF 2 receptor agonist urocortin 2 was infused into the lateral septum of mice under low or high stress ( 30 min of immobilization ) testing conditions , and then behavior in the light dark box , open field , and novel object tests was assessed . ^^^ However , in the high stress condition , 48 pmol of septal urocortin 2 significantly increased anxiety compared with control in wild type but not CRF 2 receptor knock out mice in the light dark box . ^^^ Septal administration of the relatively selective CRF 2 antagonist astressin 2B , but not the CRF 1 selective antagonist antalarmin , blocked the anxiogenic effects of urocortin 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The three urocortins have considerably higher affinities for CRF receptor type 2 ( CRF R 2 ) than CRF , and urocortin 2 and urocortin 3 are highly selective for CRF R 2 . ^^^ Urocortin 2 induced vasodilation was significantly attenuated by a CRF R 2 selective antagonist , antisauvagine 30 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Central administration of urocortin 2 ( 0 . 24 , 2 . 4 , 24 , or 240 nmol , i . c . v . ) , which selectively binds to CRF R 2 , resulted in a dose dependent suppression of LH pulses . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| In vivo studies suggest that corticotrophin releasing factor ( CRF ) and CRF like peptides , urocortin 1 ( UCN 1 ) and UCN 2 , inhibit gastric emptying and stimulate colonic motility through CRF 2 and CRF 1 receptors , respectively . ^^^ We evaluated expression and functions of CRF , UCN 1 , UCN 2 and CRF 1 and CRF 2 receptors in the rat gastric antrum . ^^^ Quantitative RT PCR demonstrated UCN 2 , CRF 1 and CRF 2 receptors expressions in both muscle layers and mucosa of the gastric antrum . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR and fluorescent in situ hybridization , we demonstrated that UCN 2 and type 2 CRH receptor ( CRH R 2 ) mRNAs were expressed in human nonpregnant and pregnant myometrium . ^^^ Immunofluorescent studies confirmed protein expression of UCN 2 in human pregnant myometrial cells , whereas chemical cross linking studies with radiolabeled UCN 2 confirmed the presence of CRH R 2 sites with an apparent molecular mass of 50 kDa . ^^^ Treatment of primary human myometrial cells with UCN 2 to specifically activate CRH R 2 resulted in a dose dependent increase of myosin light chain ( MLC ( 20 ) ) phosphorylation . ^^^ Collectively , our data suggest a distinctive role for CRH R 2 specific agonists like UCN 2 in the control of myometrial contractility during human pregnancy involving sequential activation of PKC , MAPK kinase 1 , ERK1 / 2 , RhoA , and RhoA associated kinase , leading to the MLC ( 20 ) phosphorylation . . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The effects of Ucn 2 were attenuated by astressin 2 B , a specific antagonist of CRH R 2 , and / or H 89 , an inhibitor of protein kinase A ( PKA ) . ^^^ These results indicate that Ucn 2 may be another endogenous cardiovascular substance that acts via CRH R 2 and the cAMP dependent PKA pathway . . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The heptahelical receptors for corticotropin releasing factor ( CRF ) , CRFR 1 and CRFR 2 , display different specificities for CRF family ligands : CRF and urocortin 1 bind to CRFR 1 with high affinity , whereas urocortin 2 and 3 bind to this receptor with very low affinities . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| UCN is able to bind to two types of G protein coupled receptors : CRF receptor type 1 ( CRFR 1 ) and CRF receptor type 2 ( CRFR 2 ) , whereas , two homologues of UCN , stresscopin ( SCP ) or also known as urocortin 3 ( UCNIII ) and stresscopin related peptide ( SRP ) , or urocortin 2 ( UCNII ) , bind exclusively and with high affinity to CRFR 2 , we hypothesised that they will exhibit more pronounced cardioprotective effects than UCN . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The CRFR 2 selective antagonist astressin 2 B and an ERK1 / 2 p 42 , 44 inhibitor abolish the cardioprotective actions of Ucn 2 and Ucn 3 in reperfusion . ^^^ We propose the use of CRFR 2 selective agonists , Ucn 2 and Ucn 3 , to treat ischemic heart disease because of their potent cardioprotective effects in the murine heart and their minimal impact on the hypothalamic stress axis . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| We found a significant increase in Ucn 2 mRNA levels in the skin , but not in skeletal muscle , of both CRFR 1 and CRFR 2 null mice compared with their wild type littermates . ^^^ Further examination of the distribution and regulation of CRFR 2 and its specific ligand Ucn 2 in the skin and skeletal muscle tissues may reveal the manner by which the CRFR 2 pathway is involved in the physiological responses to stress in these tissues and in other pathophysiologies of the skin and muscle . . ^^^ Urocortin 2 gene is highly expressed in mouse skin and skeletal muscle tissues : localization , basal expression in corticotropin releasing factor receptor ( CRFR ) 1 and CRFR 2 null mice , and regulation by glucocorticoids . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The mammalian family members include CRF , urocortinI ( UcnI ) , UcnII , and UcnIII , along with two receptors , CRFR 1 and CRFR 2 , and a CRF binding protein . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| The UCN homologues SCP and SRP bind specifically to the CRFR 2 receptor , whereas UCN binds to both CRFR 1 and CRFR 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| ICV infusion of the CRF receptor subtype CRFR 2 selective agonists urocortin 2 and 3 ( UCN 2 , UCN 3 ) inhibited sexual receptivity in hormone primed , ovariectomized hamsters . ^^^ Furthermore , the CRFR 2 selective antagonist , astressin 2B , prevented the inhibition of estrous behavior by UCN 2 and by NPY , consistent with a role for CRFR 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| In addition , high doses of CRH are required to produce LH , which is known to be mediated by 5 HT excitation , and the CRHR 2 agonist urocortin 2 ( UCN 2 ) produces LH at much lower doses than does CRH . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| CRH mRNA levels did not change during the luteal phase , whereas expression of UCN , UCN 2 , CRHR 1 , and CRHR 2 was maximal at early or mid luteal phase before declining ( P < 0 . 05 ) at the later stages . ^^^ |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q96RP3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| UCN is able to bind to two types of G protein coupled receptors : CRF receptor type 1 ( CRFR 1 ) and CRF receptor type 2 ( CRFR 2 ) , whereas , two homologues of UCN , stresscopin ( SCP ) or also known as urocortin 3 ( UCNIII ) and stresscopin related peptide ( SRP ) , or urocortin 2 ( UCNII ) , bind exclusively and with high affinity to CRFR 2 , we hypothesised that they will exhibit more pronounced cardioprotective effects than UCN . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Selective activation of the CRF 2 receptor by stresscopin related peptide ( SRP ; i . p . 25 microg kg 1 ) reduced the distension induced visceromotor and behavioural response . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR and fluorescent in situ hybridization , we demonstrated that UCN 2 and type 2 CRH receptor ( CRH R 2 ) mRNAs were expressed in human nonpregnant and pregnant myometrium . ^^^ Immunofluorescent studies confirmed protein expression of UCN 2 in human pregnant myometrial cells , whereas chemical cross linking studies with radiolabeled UCN 2 confirmed the presence of CRH R 2 sites with an apparent molecular mass of 50 kDa . ^^^ Treatment of primary human myometrial cells with UCN 2 to specifically activate CRH R 2 resulted in a dose dependent increase of myosin light chain ( MLC ( 20 ) ) phosphorylation . ^^^ Collectively , our data suggest a distinctive role for CRH R 2 specific agonists like UCN 2 in the control of myometrial contractility during human pregnancy involving sequential activation of PKC , MAPK kinase 1 , ERK1 / 2 , RhoA , and RhoA associated kinase , leading to the MLC ( 20 ) phosphorylation . . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Ucn 2 is expressed in the adrenal medulla , and its receptor , CRF 2 receptor , is also expressed in the adrenal gland . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| In addition , high doses of CRH are required to produce LH , which is known to be mediated by 5 HT excitation , and the CRHR 2 agonist urocortin 2 ( UCN 2 ) produces LH at much lower doses than does CRH . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The CRFR 2 selective antagonist astressin 2 B and an ERK1 / 2 p 42 , 44 inhibitor abolish the cardioprotective actions of Ucn 2 and Ucn 3 in reperfusion . ^^^ We propose the use of CRFR 2 selective agonists , Ucn 2 and Ucn 3 , to treat ischemic heart disease because of their potent cardioprotective effects in the murine heart and their minimal impact on the hypothalamic stress axis . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| We found a significant increase in Ucn 2 mRNA levels in the skin , but not in skeletal muscle , of both CRFR 1 and CRFR 2 null mice compared with their wild type littermates . ^^^ Further examination of the distribution and regulation of CRFR 2 and its specific ligand Ucn 2 in the skin and skeletal muscle tissues may reveal the manner by which the CRFR 2 pathway is involved in the physiological responses to stress in these tissues and in other pathophysiologies of the skin and muscle . . ^^^ |
|
| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) , a CRF related peptide that selectively binds CRF 2 receptors , was recently identified and recognized for its central anorectic properties . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) and Ucn 3 are new members of the corticotropin releasing factor ( CRF ) family and bind selectively to the CRF type 2 receptor ( CRF 2 ) . ^^^ These results suggest that the CRF 2 receptor is involved in motor suppressive effects as well as anxiolytic and anorectic effects of Ucn 2 and Ucn 3 . . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| In addition to urocortin ( Ucn 1 ) , Ucn 2 and Ucn 3 were identified as endogenous ligands for corticotropin releasing factor type 2 receptor ( CRF 2 receptor ) . ^^^ Therefore , it is thought that Ucn 2 may modulate CRF and vasopressin synthesis in the PVN in a paracrine or autocrine fashion through PVN CRF 2 receptor . ^^^ The systemic administration of Ucn 2 decreases mean arterial pressure ( arterial vascular tone ) and causes tachycardia via vascular CRF 2 receptor in rats , similar to the effects of Ucn 1 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 binds with high affinity to CRF type 1 ( CRF 1 ) and type 2 ( CRF 2 ) receptors while Ucn 2 and Ucn 3 are selective CRF 2 ligands . ^^^ In addition , Ucn 2 showed visceral anti nociceptive activity associated with the selective activation of CRF 2 receptors . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The intra DRN administration of the selective CRF 2 agonist urocortin 2 ( Ucn 2 ) dose dependently increased 5 HT efflux in the basolateral amygdala , a projection region of the DRN . ^^^ Both of these effects of Ucn 2 were completely blocked by intra DRN antisauvagine 30 ( ASV 30 ) , a relatively selective CRF 2 antagonist . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| ICV infusion of the CRF receptor subtype CRFR 2 selective agonists urocortin 2 and 3 ( UCN 2 , UCN 3 ) inhibited sexual receptivity in hormone primed , ovariectomized hamsters . ^^^ Furthermore , the CRFR 2 selective antagonist , astressin 2B , prevented the inhibition of estrous behavior by UCN 2 and by NPY , consistent with a role for CRFR 2 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| In the gastrointestinal tract , these compounds open new therapeutic options in the treatment of lower GI inflammatory diseases associated to CRF , such as the chronic inflammatory bowel syndromes , irritable bowel disease and ulcerative colitis while Ucn , Ucn 1 , Ucn 2 or synthetic non peptide CRF 2 agonists may be useful in the treatment of upper GI inflammatory diseases . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The effects of Ucn 2 were attenuated by astressin 2 B , a specific antagonist of CRH R 2 , and / or H 89 , an inhibitor of protein kinase A ( PKA ) . ^^^ These results indicate that Ucn 2 may be another endogenous cardiovascular substance that acts via CRH R 2 and the cAMP dependent PKA pathway . . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| In vivo studies suggest that corticotrophin releasing factor ( CRF ) and CRF like peptides , urocortin 1 ( UCN 1 ) and UCN 2 , inhibit gastric emptying and stimulate colonic motility through CRF 2 and CRF 1 receptors , respectively . ^^^ We evaluated expression and functions of CRF , UCN 1 , UCN 2 and CRF 1 and CRF 2 receptors in the rat gastric antrum . ^^^ Quantitative RT PCR demonstrated UCN 2 , CRF 1 and CRF 2 receptors expressions in both muscle layers and mucosa of the gastric antrum . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| To determine if the CRF 2 receptor agonist urocortin 2 ( Ucn 2 ) increases c Fos expression in rat DR serotonergic neurons via actions on CRF 2 receptors , we gave intracerebroventricular ( icv ) injections of mouse Ucn 2 after icv injections of either saline or the CRF 2 receptor antagonist antisauvagine 30 ( ASV 30 ) . ^^^ Mouse Ucn 2 had no effect on c Fos expression within the median raphe nucleus , consistent with the hypothesis that Ucn 2 has specific actions on an anatomically and functionally distinct subset of serotonergic neurons via activation of CRF 2 receptors . ^^^ These findings are also consistent with the hypothesis that Ucn 2 , or another CRF related neuropeptide acting at CRF 2 receptors , modulates physiological and behavioral responses to stress related stimuli via actions on a specific subset of serotonergic neurons within the dorsal raphe nucleus . . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| CRH mRNA levels did not change during the luteal phase , whereas expression of UCN , UCN 2 , CRHR 1 , and CRHR 2 was maximal at early or mid luteal phase before declining ( P < 0 . 05 ) at the later stages . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The heptahelical receptors for corticotropin releasing factor ( CRF ) , CRFR 1 and CRFR 2 , display different specificities for CRF family ligands : CRF and urocortin 1 bind to CRFR 1 with high affinity , whereas urocortin 2 and 3 bind to this receptor with very low affinities . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Behavioral and neuroendocrine effects of the selective CRF 2 receptor agonists urocortin 2 and urocortin 3 . ^^^ We compared the in vivo efficacy of two selective CRF 2 agonists , mouse urocortin 2 ( mUcn 2 ) and human urocortin 3 ( hUcn 3 ) , using food intake , anxious behavior , or ACTH release in CD 1 or Balb / c mice as indices of biological stress responses . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Central administration of urocortin 2 ( 0 . 24 , 2 . 4 , 24 , or 240 nmol , i . c . v . ) , which selectively binds to CRF R 2 , resulted in a dose dependent suppression of LH pulses . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| CRF ( 0 . 1 4 nmol ) , urocortin 2 ( a selective CRF 2 receptor agonist 2 . 5 100 pmol ) , or saline vehicle was injected intracisternally , and changes in hepatic circulation were observed for 120 minutes . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| To determine if CRF 2 receptor activation has effects on serotonergic neurons in the DR in conscious behaving rats , we gave intracerebroventricular ( icv ) injections of the selective CRF 2 receptor agonist urocortin 2 ( 0 , 0 . 01 , 0 . 1 , or 1 . 0 mug in 2 microl saline ) to adult male Wistar rats and quantified c Fos expression in topographically organized subpopulations of serotonergic neurons within the DR . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR 2 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The selective CRF 2 agonist , human urocortin 2 ( hUcn 2 , at 10 and 20 microg / kg ) , injected intravenous after the first distension , prevented sensitisation and reduced the second response by 8 ( 1 ) % and 30 ( 5 ) % ( p < 0 . 05 ) compared with the first response , respectively . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| METHODS : The present study examined : ( 1 ) the time course and dose response functions for the effects of human / rat ( h / r ) CRF ( 0 . 02 0 . 6 nmol , ICV ( intracerebroventricular ) ) on ASR in two inbred strains of mice ; ( 2 ) the effects of the CRF 1 receptor antagonist NBI 30775 ( 20 mg / kg , intraperitoneal ) and the CRF 2 receptor antagonist Antisauvagine 30 ( 1 10 nmol , ICV ) on CRF potentiated ASR and ( 3 ) the effects of the CRF 2 receptor agonist urocortin 2 ( 0 . 2 6 nmol , ICV ) on ASR in mice . ^^^ The selective CRF 2 receptor agonist urocortin 2 increased ASR ( 1 and 2 nmol ) , albeit with less efficacy than the non selective CRF receptor agonist h / r CRF . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The three urocortins have considerably higher affinities for CRF receptor type 2 ( CRF R 2 ) than CRF , and urocortin 2 and urocortin 3 are highly selective for CRF R 2 . ^^^ Urocortin 2 induced vasodilation was significantly attenuated by a CRF R 2 selective antagonist , antisauvagine 30 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The UCN homologues SCP and SRP bind specifically to the CRFR 2 receptor , whereas UCN binds to both CRFR 1 and CRFR 2 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The mammalian family members include CRF , urocortinI ( UcnI ) , UcnII , and UcnIII , along with two receptors , CRFR 1 and CRFR 2 , and a CRF binding protein . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Corticotropin releasing factor ( CRF ) and the CRF like peptide urocortin 1 ( UcnI ) exert their activity through two different CRF receptors , CRF 1 and CRF 2 . ^^^ |
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| Interacting proteins: Q96RP3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The selective CRF 2 receptor agonist urocortin 2 was infused into the lateral septum of mice under low or high stress ( 30 min of immobilization ) testing conditions , and then behavior in the light dark box , open field , and novel object tests was assessed . ^^^ However , in the high stress condition , 48 pmol of septal urocortin 2 significantly increased anxiety compared with control in wild type but not CRF 2 receptor knock out mice in the light dark box . ^^^ Septal administration of the relatively selective CRF 2 antagonist astressin 2B , but not the CRF 1 selective antagonist antalarmin , blocked the anxiogenic effects of urocortin 2 . ^^^ |
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