| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.85392082 |
| However , TRPM 6 specifically interacted with its closest homolog , the Mg ( 2+ ) permeable cation channel TRPM 7 , resulting in the assembly of functional TRPM6 / TRPM7 complexes at the cell surface . 0.85392082^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Two of these alpha kinases , named channel kinases 1 and 2 ( ChaK 1 and ChaK 2 ) represent a new type of signaling molecules that are protein kinases fused to ion channels . . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Whereas electrophysiological and biochemical analyses identified TRPM 7 as an important player in cellular magnesium homeostasis , the critical role of TRPM 6 for epithelial magnesium transport emerged from the discovery of loss of function mutations in patients with a severe form of hereditary hypomagnesaemia called primary hypomagnesaemia with secondary hypocalcaemia or HSH . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Sequencing did not reveal any TRPM 6 or TRPM 7 gene mutations in the female HSH patient with an 10 ; 9 translocation . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| The TRPM 6 protein is a new member of the long transient receptor potential channel ( TRPM ) family and is highly similar to TRPM 7 ( also known as TRP PLIK ) , a bifunctional protein that combines calcium and magnesium permeable cation channel properties with protein kinase activity . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| TRPM 6 and TRPM 7 are distinct from all other ion channels in that they are composed of linked channel and protein kinase domains . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| This includes reports about ADP ribose functioning as a novel intracellular second messenger and gating molecule of the Ca ( 2+ ) permeable TRPM 2 channel , studies demonstrating the central role of mouse TRPM 5 in taste signaling , as well as the unexpected involvement of TRPM 6 and TRPM 7 in regulating Mg ( 2+ ) homeostasis , or the cool properties of TRPM 8 acting as a cold and menthol sensor in sensory neurons . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| We used the whole cell voltage clamp technique in pig and rat ventricular myocytes to characterize the permeation , blockage properties and regulation of the cardiac IMIC channels in order to compare them with TRP channels , in particular with Mg2+ sensitive TRPM 6 and TRPM 7 . ^^^ Their efficacy sequence in decreasing outward IMIC ( Ni2+ = Mg2+ > Ca2+ > Ba2+ ) and in inducing inward IMIC ( Ni2+ > > Mg2+ = Ca2+ approximately Ba2+ ) , and their permeabilities calculated from reversal potentials are similar to those of TRPM 6 and TRPM 7 channels . ^^^ Our results suggest that IMIC in cardiac cells is due to TRPM channels , most probably to TRPM 6 or TRPM 7 channels or to their heteromultimeres . . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| These epithelial Ca ( 2+ ) ( TRPV 5 and TRPV 6 ) and Mg ( 2+ ) channels ( TRPM 6 and TRPM 7 ) form prime targets for hormonal control of the active Ca ( 2+ ) and Mg ( 2+ ) flux from the urine space or intestinal lumen to the blood compartment . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| On the other hand , TRPM 8 and TRPA 1 have been described as cold receptors , TRPM 4 and TRPM 5 as calcium activated nonselective cation channels , TRPM 6 and TRPM 7 as magnesium permeable and magnesium modulated cation channels , TRPM 2 as an ADP ribose activated channel of macrophages , and TRPM 3 as a hypo osmolarity and sphingosine activated channel . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Some functions are linked to their individual cation selectivity : the highly divalent permeable cation channels TRPM 6 and TRPM 7 are involved in the control of Mg ( 2+ ) influx , whereas the Ca ( 2+ ) impermeable channels TRPM 4 and TRPM 5 modulate cellular Ca ( 2+ ) entry by determining the membrane potential . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Among the recently discovered TRP cation channels two homologous proteins , TRPM 6 and TRPM 7 , display unique domain compositions and biophysical properties . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| TRPM 7 , the closest homologue of TRPM 6 , has a central role in Mg ( 2+ ) uptake in vertebrate cells since TRPM 7 deficient cells become Mg ( 2+ ) deficient and are not viable . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Here , we tested the hypothesis that downregulation of TRPM 7 and its homologue TRPM 6 is associated with reduced [ Mg2+ ] 1 and that ANG 2 negatively regulates TRPM6 / 7 in vascular smooth muscle cells ( VSMCs ) from spontaneously hypertensive rats ( SHR ) . ^^^ Cultured VSMCs from Wistar Kyoto ( WKY ) and SHR were studied . mRNA and protein expression of TRPM 6 and TRPM 7 were assessed by RT PCR and immunoblotting , respectively . ^^^ VSMCs from WKY and SHR express TRPM 6 and TRPM 7 . ^^^ Basal TRPM 6 expression was similar in WKY and SHR , but basal TRPM 7 content was lower in VSMCs from SHR vs . ^^^ Our findings demonstrate that TRPM 6 and TRPM 7 are differentially regulated in VSMCs from SHR and WKY . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| The channel kinases TRPM 6 and TRPM 7 are functionally nonredundant . ^^^ TRPM 7 and its closest homologue , TRPM 6 , are the only known fusions of an ion channel pore with a kinase domain . ^^^ Amazingly , in analogy to TRPM 6 deficient patients who can live a normal life if provided with a Mg ( 2+ ) rich diet , TRPM 7 deficient DT 40 B lymphocytes show wild type cell growth if supplied with 5 10 mm Mg ( 2+ ) concentrations in their extracellular medium . ^^^ Here we have investigated the functional relationship between TRPM 6 and TRPM 7 . ^^^ We show that TRPM 7 deficiency in DT 40 cells can not be complemented by heterologously expressed TRPM 6 . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| TRPM 6 and TRPM 7 , bifunctional proteins with kinase and ion channel activities , are responsible for magnesium homeostasis . ^^^ It was confirmed that TRPM 6 protein is responsible for homeostasis in the whole organism and that TRPM 7 may regulate the level of magnesium in the cell . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Identification of the gene defect in hypomagnesemia with secondary hypocalcemia recently elucidated transient receptor potential melastatin 6 ( TRPM 6 ) as the gatekeeper in transepithelial Mg ( 2+ ) transport , whereas its homolog , TRPM 7 , is implicated in cellular Mg ( 2+ ) homeostasis . ^^^ The aim of this study was to determine the tissue distribution in mouse and regulation of TRPM 6 and TRPM 7 by dietary Mg ( 2+ ) and hormones . ^^^ This study demonstrates that TRPM 6 is expressed predominantly in kidney , lung , cecum , and colon , whereas TRPM 7 is distributed ubiquitously . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| Functional characterization of homo and heteromeric channel kinases TRPM 6 and TRPM 7 . ^^^ TRPM 6 and TRPM 7 are two known channel kinases that play important roles in various physiological processes , including Mg2+ homeostasis . ^^^ Here we demonstrate several signature features of TRPM 6 that distinguish TRPM 6 from TRPM 7 and TRPM6 / 7 channels . ^^^ We show that heterologous expression of TRPM 6 but not the mutant TRPM 6 ( S141L ) produces functional channels with divalent cation permeability profile and pH sensitivity distinctive from those of TRPM 7 channels and TRPM6 / 7 complexes . ^^^ TRPM 6 exhibits unique unitary conductance that is 2 and 1 . 5 fold bigger than that of TRPM 7 and TRPM6 / 7 . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| The Mg ( 2+ ) inhibited cation ( MIC ) current ( 1 ( MIC ) ) in cardiac myocytes biophysically resembles currents of heterologously expressed transient receptor potential ( TRP ) channels , particularly TRPM 6 and TRPM 7 , known to be important in Mg ( 2+ ) homeostasis . ^^^ |
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| Interacting proteins: Q9BX84 and Q96QT4 |
Pubmed |
SVM Score :0.0 |
| The tissues demonstrating highest expression for individual family members were brain ( TRPM 1 ) , brain and bone marrow ( TRPM 2 ) , brain and pituitary ( TRPM 3 ) , intestine and prostate ( TRPM 4 ) , intestine , pancreas , and prostate ( TRPM 5 ) , intestine and brain ( TRPM 6 ) , heart , pituitary , bone , and adipose tissue ( TRPM 7 ) , and prostate and liver ( TRPM 8 ) . ^^^ |
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