| Interacting proteins: Q8WW12 and Q96PU4 |
Pubmed |
SVM Score :0.59116498 |
| Interaction between PCNP and NIRF was clarified by mammalian two hybrid system , GST pull down assay , and nuclear co localization . 0.59116498^^^ |
|
| Interacting proteins: Q8WW12 and Q96PU4 |
Pubmed |
SVM Score :0.0 |
| NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP , a PEST containing nuclear protein . ^^^ We previously reported the association of a novel Np95 / ICBP90 like RING finger protein ( NIRF ) with a novel PEST containing nuclear protein ( PCNP ) . ^^^ PCNP was readily ubiquitinated in 293 and COS 7 cells , and NIRF ubiquitinated PCNP in vitro as well as in vivo . ^^^ Considering that NIRF is implicated in cell cycle regulation , these findings suggest that NIRF and PCNP are a ubiquitin ligase and its substrate , respectively , and may constitute a novel signaling pathway with some relation to cell proliferation . . ^^^ |
|
| Interacting proteins: Q96PU4 and Q8WW12 |
Pubmed |
SVM Score :0.59116498 |
| Interaction between PCNP and NIRF was clarified by mammalian two hybrid system , GST pull down assay , and nuclear co localization . 0.59116498^^^ |
|
| Interacting proteins: Q96PU4 and Q8WW12 |
Pubmed |
SVM Score :0.0 |
| We previously reported the association of a novel Np95 / ICBP90 like RING finger protein ( NIRF ) with a novel PEST containing nuclear protein ( PCNP ) . ^^^ NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP , a PEST containing nuclear protein . ^^^ PCNP was readily ubiquitinated in 293 and COS 7 cells , and NIRF ubiquitinated PCNP in vitro as well as in vivo . ^^^ Considering that NIRF is implicated in cell cycle regulation , these findings suggest that NIRF and PCNP are a ubiquitin ligase and its substrate , respectively , and may constitute a novel signaling pathway with some relation to cell proliferation . . ^^^ |
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