| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| We show that HES 1 mRNA is also expressed in a cyclic fashion in the mouse PSM , similar to that observed for c hairy 1 and c hairy 2 in the chick . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| The bHLH gene Hes 6 , an inhibitor of Hes 1 , promotes neuronal differentiation . ^^^ Hes 6 is expressed by both undifferentiated and differentiated cells , unlike Hes 1 , which is expressed only by the former cells . ^^^ Hes 6 alone does not bind to the DNA but suppresses Hes 1 from repressing transcription . ^^^ In addition , Hes 6 suppresses Hes 1 from inhibiting Mash 1 E47 heterodimer and thereby enables Mash 1 and E 47 to upregulate transcription in the presence of Hes 1 . ^^^ Furthermore , misexpression of Hes 6 with retrovirus in the developing retina promotes rod photoreceptor differentiation , like Mash 1 , in sharp contrast to Hes 1 , which inhibits cell differentiation . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| On N box containing promoters , HES 6 cooperated with HES 1 to achieve maximal repression . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| Three of the four murine Notch receptors , their ligands , Delta like 1 ( Dll 1 ) , Jagged 1 , and Jagged 2 , as well as three transcription factors , Hes 1 , Hes 6 , and Mash 1 , are expressed in the embryonic taste epithelium . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| Hes 6 promotes cortical neurogenesis and inhibits Hes 1 transcription repression activity by multiple mechanisms . ^^^ In contrast to Hes 1 , the related protein Hes 6 promotes neuronal differentiation . ^^^ It is shown here that Hes 6 antagonizes Hes 1 function by two mechanisms . ^^^ Hes 6 inhibits the interaction of Hes 1 with its transcriptional corepressor Gro / TLE . ^^^ This effect is maximal when both Hes 1 and Hes 6 contain the WRPW motif and is reduced when Hes 6 is mutated to eliminate a conserved site ( Ser 183 ) that can be phosphorylated by protein kinase CK 2 . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| Phylogenetic analyses revealed that bHLH transcription factors with ORANGE domain were classified into the following three groups : ( group 1 ) HES 1 , HES 2 , HES 4 and HES 6 orthologs ; ( group 2 ) HESL , HES 5 , HES 7 , HEY 1 , HEY 2 and HEYL orthologs ; ( group 3 ) HES 3 , DEC1 / BHLHB2 and DEC2 / BHLHB3 orthologs . . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| ASCL 1 upregulation in progressive astrocytoma is accompanied by inhibition of Notch signaling as seen by uninduced levels of HES 1 , a transcriptional target of Notch 1 , increased levels of HES 6 , a dominant negative inhibitor of HES 1 mediated repression of ASCL 1 , and increased levels of Notch ligand Delta 1 , which is capable of inhibiting Notch signaling by forming intracellular Notch ligand autonomous complexes . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| Expression of HES / HEY family members , including HES 1 , HES 2 , HES 3 , HES 4 , HES 5 , HES 6 , HES 7 , HEY 1 , HEY 2 and HEYL , in coronary artery endothelial cells was not detected in silico . ^^^ |
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| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96HZ4 and Q14469 |
Pubmed |
SVM Score :0.0 |
| NA |
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