| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| We have identified two novel yeast genes , THO 1 and THO 2 , that partially suppress the transcription defects of hpr1Delta mutants by overexpression . ^^^ We show by in vivo transcriptional and recombinational analysis of tho2Delta cells that THO 2 plays a role in RNA polymerase 2 ( RNA pol 2 ) dependent transcription and is required for the stability of DNA repeats , as previously shown for HPR 1 . ^^^ Our work not only identifies a novel yeast gene , THO 2 , with similar function to HPR 1 , but also provides new evidence for transcriptional blocks as a source of recombination . ^^^ |
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| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| Hpr 1 forms , together with Tho 2 , Mft 1 , and Thp 2 , the THO complex , which controls transcription elongation and genome stability in Saccharomyces cerevisiae . ^^^ |
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| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| We also show that Sub 2 and Yra 1 interact genetically with all four components of the THO complex ( Tho 2 , Hpr 1 , Mft 1 and Thp 2 ) . ^^^ |
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| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| The THO complex is a multimeric factor containing four polypeptides , Tho 2 , Hpr 1 , Mft 1 and Thp 2 . ^^^ |
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| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| Here we report that Drosophila melanogaster THO consists of THO 2 , HPR 1 and three proteins , THOC 5 THOC7 , which have no orthologs in budding yeast . ^^^ |
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| Interacting proteins: Q96FV9 and Q8NI27 |
Pubmed |
SVM Score :0.0 |
| A protein complex containing Tho 2 , Hpr 1 , Mft 1 and a novel protein , Thp 2 , connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae . ^^^ We have shown previously that the yeast genes HPR 1 and THO 2 may be keys to the understanding of transcription associated recombination , as they both affect transcription elongation and hyper recombination in a concerted manner . ^^^ Using a yeast strain that has the wild type THO 2 gene replaced by one encoding a His ( 6 ) HA tagged version , we have isolated an oligomeric complex containing four proteins : Tho 2 , Hpr 1 , Mft 1 and a novel protein that we have named Thp 2 . ^^^ We have reciprocally identified a complex containing Hpr 1 , Tho 2 and Mft 1 using anti Mft 1 antibodies in immunoprecipitation experiments . ^^^ The protein complex is mainly nuclear ; therefore , Tho 2 and Hpr 1 are physically associated . ^^^ |
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