| Interacting proteins: Q96FV9 and P06400 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein . ^^^ |
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| Interacting proteins: Q96FV9 and P06400 |
Pubmed |
SVM Score :0.0 |
| The nuclear death domain containing protein p84N5 can induce apoptosis that is inhibited by association with Rb . ^^^ This conclusion is consistent with the hypotheses that p84N5 functions in an Rb regulated cellular response that is similar to that triggered by DNA damage . . ^^^ |
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| Interacting proteins: Q96FV9 and P06400 |
Pubmed |
SVM Score :0.0 |
| Nuclear localization is required for induction of apoptotic cell death by the Rb associated p84N5 death domain protein . ^^^ We have previously characterized a death domain protein , p84N5 , that specifically associates with an amino terminal domain of Rb protein . ^^^ Association with Rb protein inhibits p84N5 induced apoptosis suggesting that it may be a mediator of Rb ' s effects on apoptosis . ^^^ Further , p84N5 is a potential mediator of Rb protein ' s effects on DNA damage induced apoptosis . . ^^^ |
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