| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| Human methionine synthase reductase ( MSR ) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob ( 2 ) alamin form of methionine synthase ( MS ) . ^^^ Electron transfer from MSR to the cob ( 2 ) alamin cofactor coupled with methyl transfer from S adenosyl methionine returns MS to the active methylcob ( 3 ) alamin state . ^^^ MSR contains stoichiometric amounts of FAD and FMN , which shuttle NADPH derived electrons to the MS cob ( 2 ) alamin cofactor . ^^^ |
|
| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| Methionine synthase reductase ( MTRR ) regenerates methylated cobalamin levels from the oxidised cob ( 2 ) alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase ( MTR ) . ^^^ |
|
| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| MSR also is able to reduce aquacobalamin to cob ( 2 ) alamin in the presence of NADPH , and this reduction leads to stimulation of the conversion of apoMS and aquacobalamin to MS holoenzyme . ^^^ |
|
| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| Human methionine synthase reductase ( MSR ) is a protein containing both FAD and FMN , and it reactivates methionine synthase that has lost activity due to oxidation of cob ( 1 ) alamin to cob ( 2 ) alamin . ^^^ |
|
| Interacting proteins: Q96EY8 and Q9UBK8 |
Pubmed |
SVM Score :0.0 |
| Investigations also showed that purified recombinant human methionine synthase reductase ( MSR ) in combination with purified ATR can convert cob ( 2 ) alamin to AdoCbl in vitro . ^^^ In this system , MSR reduced cob ( 2 ) alamin to cob ( 1 ) alamin that was adenosylated to AdoCbl by ATR . ^^^ The optimal stoichiometry for this reaction was approximately 4 MSR / ATR and results indicated that MSR and ATR physically interacted in such a way that the highly reactive reaction intermediate [ cob ( 1 ) alamin ] was sequestered . ^^^ The finding that MSR reduced cob ( 2 ) alamin to cob ( 1 ) alamin for AdoCbl synthesis ( in conjunction with the prior finding that MSR reduced cob ( 2 ) alamin for the activation of methionine synthase ) indicates a dual physiological role for MSR . . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| Human methionine synthase reductase ( MSR ) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob ( 2 ) alamin form of methionine synthase ( MS ) . ^^^ Electron transfer from MSR to the cob ( 2 ) alamin cofactor coupled with methyl transfer from S adenosyl methionine returns MS to the active methylcob ( 3 ) alamin state . ^^^ MSR contains stoichiometric amounts of FAD and FMN , which shuttle NADPH derived electrons to the MS cob ( 2 ) alamin cofactor . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| Human methionine synthase reductase ( MSR ) is a protein containing both FAD and FMN , and it reactivates methionine synthase that has lost activity due to oxidation of cob ( 1 ) alamin to cob ( 2 ) alamin . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| Investigations also showed that purified recombinant human methionine synthase reductase ( MSR ) in combination with purified ATR can convert cob ( 2 ) alamin to AdoCbl in vitro . ^^^ In this system , MSR reduced cob ( 2 ) alamin to cob ( 1 ) alamin that was adenosylated to AdoCbl by ATR . ^^^ The optimal stoichiometry for this reaction was approximately 4 MSR / ATR and results indicated that MSR and ATR physically interacted in such a way that the highly reactive reaction intermediate [ cob ( 1 ) alamin ] was sequestered . ^^^ The finding that MSR reduced cob ( 2 ) alamin to cob ( 1 ) alamin for AdoCbl synthesis ( in conjunction with the prior finding that MSR reduced cob ( 2 ) alamin for the activation of methionine synthase ) indicates a dual physiological role for MSR . . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| MSR also is able to reduce aquacobalamin to cob ( 2 ) alamin in the presence of NADPH , and this reduction leads to stimulation of the conversion of apoMS and aquacobalamin to MS holoenzyme . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| Methionine synthase reductase ( MTRR ) regenerates methylated cobalamin levels from the oxidised cob ( 2 ) alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase ( MTR ) . ^^^ |
|
| Interacting proteins: Q9UBK8 and Q96EY8 |
Pubmed |
SVM Score :0.0 |
| NA |
|