| Interacting proteins: Q96DE7 and Q15797 |
Pubmed |
SVM Score :0.80961425 |
| In both yeast two hybrid and in vitro binding assays , we found that Smurf 2 could interact with receptor activated Smads ( R Smads ) , including Smad 1 , Smad 2 , and Smad 3 but not Smad 4 . 0.80961425^^^ |
|
| Interacting proteins: Q96DE7 and Q15797 |
Pubmed |
SVM Score :0.0 |
| Smurf 2 selectively interacts with receptor regulated Smads and preferentially targets Smad 1 for ubiquitination and proteasome mediated degradation . ^^^ In Xenopus embryos , ectopic Smurf 2 expression specifically inhibits Smad 1 responses and thereby affects embryonic patterning by bone morphogenetic protein signals . ^^^ |
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| Interacting proteins: Q96DE7 and Q15797 |
Pubmed |
SVM Score :0.0 |
| Aza treated ACs displayed less Smad 2 and 3 and increased Smad 1 , 5 , and Smurf 2 protein and showed a loss of TGF beta signaling on the P3TP luciferase reporter . ^^^ Overall , Aza treated ACs represent a novel model for the study of mechanisms that regulate maturational potential of articular cartilage , with the data suggesting that maturation of these cells may be due to up regulation of Smad 1 and 5 coupled with a Smurf 2 dependent degradation of Smad 2 and 3 and loss of TGF beta signaling . . ^^^ |
|
| Interacting proteins: Q96DE7 and Q15797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96DE7 and Q15797 |
Pubmed |
SVM Score :0.0 |
| NA |
|