| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :1.1320147 |
| Here , we identify Smurf 2 , a C 2 WW HECT domain ubiquitin ligase and show that Smurf 2 associates constitutively with Smad 7 . 1.1320147^^^ Smad 7 binds to Smurf 2 to form an E 3 ubiquitin ligase that targets the TGF beta receptor for degradation . 0.7093089^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| In particular , the PPPPY sequence of RNF 11 PY motif is identical to that of Smad 7 , which has been shown to bind to WW domains of Smurf 2 , an E 3 ubiquitin ligase that mediates the ubiquitination and degradation of the TGFbeta receptor complex . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| We also found that both Smurf 1 and Smurf 2 ( Smad ubiquitination regulatory factors ) , which are E 3 ubiquitin ligases for Smad 7 , were increased and that they interacted with Smad 7 in UUO kidneys . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| Smad ubiquitination regulatory factor 2 ( Smurf 2 ) , a ubiquitin ligase for Smads , plays critical roles in the regulation of transforming growth factor beta ( TGF beta ) Smad signaling via ubiquitin dependent degradation of Smad 2 and Smad 7 . ^^^ TGF beta mediated Smurf 2 promoter activation was inhibited by Smad 7 or an activin receptor like kinase 5 inhibitor but not by dominant negative Smad or disruption of Smad binding elements in the promoter . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| In TGFbeta signaling the inhibitory protein Smad 7 recruits Smurf 2 , an E 3 of the C 2 WW HECT domain class , to the TGFbeta receptor complex to facilitate receptor degradation . ^^^ A 2 . 1 A resolution 10 ray crystal structure of the Smurf 2 HECT domain reveals that it has a suboptimal E 2 binding pocket that could be optimized by mutagenesis to generate a HECT domain that functions independently of Smad 7 and potently inhibits TGFbeta signaling . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| An expanded WW domain recognition motif revealed by the interaction between Smad 7 and the E 3 ubiquitin ligase Smurf 2 . ^^^ Recognition of the receptors by Smurf 2 is accomplished through an intermediary protein , Smad 7 . ^^^ Here we have demonstrated that the WW 3 domain of Smurf 2 can directly bind to the Smad 7 polyproline tyrosine ( PY ) motif . ^^^ To examine this interaction , the solution structure of the complex between the Smad 7 PY motif region ( ELESPPPPYSRYPMD ) and the Smurf 2 WW3 domain was determined . ^^^ The interaction between the Smurf 2 WW3 domain and the Smad 7 PY motif is the first example of PY motif recognition by a WW domain with a Phe substituted for the binding site Trp . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| Further analysis revealed that independent of its role in anti Smad signaling , Smad 7 bound beta catenin and induced beta catenin degradation by recruiting an E 3 ligase , Smurf 2 , to the Smad7 / beta catenin complex . ^^^ Coexpression of the Smurf 2 and Smad 7 transgenes exacerbated Smad 7 induced abnormalities in hair follicles and sebaceous glands . ^^^ |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96DE7 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
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