| One identified group of SMN interacting clones encoded the DNA transactivator FUSE binding protein ( FBP ) . ^^^ FBP overexpressed in HEK 293 cells or endogenously expressed in fetal and adult mouse brain bound specifically in vitro to recombinant SMN protein . ^^^ Furthermore , an anti FBP antibody specifically co immunoprecipitated SMN when both proteins were overexpressed in HEK 293 cells . ^^^ These results demonstrate that FBP is a novel interacting partner of SMN and suggests a possible role for SMN in neuronal gene expression . . ^^^ |