| Interacting proteins: Q96AE4 and P32780 |
Pubmed |
SVM Score :0.0 |
| The FBP interacting repressor targets TFIIH to inhibit activated transcription . ^^^ A novel 60 kDa protein , the FBP interacting repressor ( FIR ) , blocked activator dependent , but not basal , transcription through TFIIH . ^^^ |
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| Interacting proteins: Q96AE4 and P32780 |
Pubmed |
SVM Score :0.0 |
| Furthermore , FBP co localized with transcription sites and with the general transcription factor TFIIH , but not with the splicing factor SC 35 . ^^^ |
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| Interacting proteins: Q96AE4 and P32780 |
Pubmed |
SVM Score :0.0 |
| Through TFIIH , FBP facilitates transcription until promoter escape , whereas after initiation , FIR uses TFIIH to delay promoter escape . ^^^ Mutations in TFIIH that impair regulation by FBP and FIR affect proper regulation of c myc expression and have implications in the development of malignancy . . ^^^ |
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| Interacting proteins: Q96AE4 and P32780 |
Pubmed |
SVM Score :0.0 |
| FBP bound to FUSE acts through TFIIH at the promoter . ^^^ |
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| Interacting proteins: Q96AE4 and P32780 |
Pubmed |
SVM Score :0.0 |
| The FUSE / FBP / FIR / TFIIH system is a molecular machine programming a pulse of c myc expression . ^^^ Because transcriptionally generated torsion melts FUSE in vitro even in linear DNA , and FBP / FBP Interacting Repressor ( FIR ) regulates transcription through TFIIH , these components have been speculated to be the mechanosensor ( FUSE ) and effectors ( FBP / FIR ) of a real time mechanism controlling c myc transcription . ^^^ After transcription was switched on by conventional factors and chromatin regulators , FBP and FIR were recruited and established a dynamically remodeled loop with TFIIH at the P 2 promoter . ^^^ |
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