| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| Editing of cytochrome c oxidase ( cox ) subunit 2 and 3 transcripts and of maxicircle unidentified reading frame ( MURF ) 2 RNA is limited to a small section and results in the creation of a potential AUG translational initiation codon ( coxIII , MURF 2 ) or the removal of a frameshift ( coxII ) . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| DNA sequence analysis from three E . coli mutants harboring the murC 3 ( G344D ) , murE 1 ( G344K , A495S ) , and murF 2 ( A288T ) mutations revealed the presence of point mutation ( s ) closely associated with the fourth of these aligned regions . ^^^ The murF 2 allele , expressed and purified as a glutathione S transferase : : MurF 2 fusion , was 181 fold less catalytically active at 30 degrees C and was further reduced at the nonpermissive temperature ( 42 degrees C ) . ^^^ Thus the murF 2 temperature sensitive phenotype arises from a point mutation within a highly conserved region within this protein family . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| A putative intramolecular cox 2 gRNA and the gene for gMURF 2 1 directing the insertion of only one U in the 5 ' editing domain of MURF 2 RNA , are conserved in B . saltans . ^^^ Phylogenetic analysis showed that B . saltans is more closely related to trypanosomatids than the cryptobiids Trypanoplasma borreli and Cryptobia helicis , in line with the trypanosomatid like cox 2 and MURF 2 RNA editing patterns . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| We have identified a novel muscle specific RING finger protein , referred to as MURF 1 , that binds in vitro to the titin repeats A168 / A169 adjacent to the titin kinase domain . ^^^ In myofibrils , MURF 1 is present within the periphery of the M line lattice in close proximity to titin ' s catalytic kinase domain , within the Z line lattice , and also in soluble form within the cytoplasm . ^^^ Yeast two hybrid screens with MURF 1 as a bait identified two other highly homologous MURF proteins , MURF 2 and MURF 3 . ^^^ MURF 1 , 2 , 3 proteins are encoded by distinct genes , share highly conserved N terminal RING domains and in vitro form dimers / heterodimers by shared coiled coil motifs . ^^^ Of the MURF family , only MURF 1 interacts with titin repeats A168 / A169 , whereas MURF 3 has been reported to affect microtubule stability . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| We show that A . teichomyceticus contains also a house keeping murF 1 gene , capable of complementing a temperature sensitive Escherichia coli murF mutant . ^^^ MurF 1 , expressed in Streptomyces lividans , can catalyze the addition of either D Ala D Ala or D Ala D Lac to the UDP N acetyl muramyl L Ala D Glu d Lys . ^^^ The Actinoplanes teichomyceticus tcp cluster , devoted to the biosynthesis of the glycopeptide antibiotic teicoplanin , contains van genes associated to a murF like sequence ( murF 2 ) . ^^^ However , similarly expressed MurF 2 shows a small enzymatic activity only with D Ala D lactate . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| Maxicircle encoded guide RNAs ( gRNAs ) for cytochrome b and maxicircle unidentified reading frames 2 and 3 ( MURF 2 and MURF 3 ) were isolated by hybrid selection and sequenced . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| Uridine additions and deletions in the 5 ' ends of the COIII , MURF 2 , and MURF 3 transcripts create new N terminal amino acid sequences that are conserved between species , and new AUG initiation codons in several cases . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| MURF 1 , MURF 2 and MURF 3 are a specific class of RING finger proteins that are expressed in striated muscle tissues . ^^^ MURF 1 , MURF 2 and MURF 3 are a specific class of RING finger proteins that are expressed in striated muscle tissues . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| Muscle specific RING finger protein 1 ( MuRF 1 ) is a sarcomere associated protein that is restricted to cardiac and skeletal muscle . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| The mrf 1 gene encodes a 17 kDa protein with a single calcium binding ( EF hand ) motif and is expressed specifically in microglia . ^^^ We have found that ATP suppresses the synthesis of the inflammation related protein MRF 1 in cultured rat microglia . ^^^ When microglia were treated with ATP ( 1 mM ) for 6 h , mrf 1 mRNA levels decreased to approximately 50 % compared to those in the control . ^^^ After ATP ( 1 mM ) treatment for 16 h , levels of mrf 1 mRNA decreased to 37 . 3 % and MRF 1 levels decreased to 55 . 0 % compared to those in the control . ^^^ A decrease in MRF 1 or its mRNA was also induced by benzoylbenzoyl ATP ( 0 . 1 mM ) , a P2X ( 7 ) receptor selective agonist , and by the Ca ( 2+ ) ionophore A 23187 ( 2 micro M ) , dependent on extracellular Ca ( 2+ ) . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| The mrf 1 gene has been isolated from microglia exposed to cultured cerebellar granule neurons undergoing apoptosis . ^^^ We have shown that mrf 1 is upregulated in response to neuronal death and degeneration both in vitro and in vivo . ^^^ However , the exact role of MRF 1 remains unknown . ^^^ Here we show that MRF 1 is released from cultured rat microglia , and its release is greatly enhanced under inflammatory conditions . ^^^ When microglia were treated with ATP , the amount of MRF 1 that was released increased 10 fold compared to the basal level of release . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| The mrf gene cluster contains 11 genes with an organization similar to that of the mrp locus from Proteus mirabilis . mrfI ( encoding a putative recombinase ) and mrfA ( encoding pilin ) , the first gene in an apparent operon of nine other genes , are expressed from divergent promoters . ^^^ |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BYV2 and Q969Q1 |
Pubmed |
SVM Score :0.0 |
| NA |
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