| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.82830473 |
| Association of MURF 1 with M line titin may potentially modulate titin ' s kinase activity similar to other known kinase associated proteins , whereas differential expression and heterodimerization of MURF 1 , 2 and 3 may link together titin kinase and microtubule dependent signal pathways in striated muscles . . 0.82830473^^^ |
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| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.80156523 |
| The dual interactions of MURF 1 with titin and GMEB 1 may link myofibril signaling pathways ( perhaps including titin ' s kinase domain ) with muscle gene expression . . 0.80156523^^^ |
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| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Titin is a giant protein responsible for muscle elasticity and provides a scaffold for several sarcomeric proteins , including the novel titin binding protein MURF 1 , which binds near the titin M line region . ^^^ |
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| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| This identified eight myofibrillar proteins as binding partners of MURF 1 : titin , nebulin , the nebulin related protein NRAP , troponin 1 ( TnI ) , troponin T ( TnT ) , myosin light chain 2 ( MLC 2 ) , myotilin and T cap . ^^^ Western blot studies on cardiac tissues from wild type and MURF 1 deficient mice suggested that titin and nebulin were ubiquitinated at similar levels , and MLC 2 and TnI at reduced levels in MURF 1 KO mice . ^^^ Mapping of the TnI and titin binding sites on MURF 1 peptide scans demonstrated their binding to motifs highly conserved between MURF 1 and MURF 2 . ^^^ |
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| Interacting proteins: Q969Q1 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF 2 RING finger protein . ^^^ We show here that the novel tubulin associated RING / B box protein MURF 2 associates transiently with microtubules , myosin and titin during sarcomere assembly . ^^^ Then , MURF 2 labelled microtubules associate transiently with sarcomeric myosin and later with A band titin when non striated myofibrils differentiate into mature sarcomeres . ^^^ Finally , MURF 2 labelled microtubules disappear from the sarcomere after the incorporation of myosin filaments and the elongation of titin . ^^^ This suggests that the incorporation of myosin into nascent sarcomeres and the elongation of titin require an active , microtubule dependent transport process and that MURF 2 associated microtubules play a role in the alignment and extension of nascent sarcomeres . ^^^ |
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