| Interacting proteins: Q99466 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation data indicate that C . elegans SEL 10 complexes with LIN 12 and with murine Notch 4 . ^^^ |
|
| Interacting proteins: Q99466 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| The Notch 4 intracellular domain bound to SEL 10 , but its activity was not increased as a result of dominant negative SEL 10 expression . ^^^ SEL 10 bound Notch 4 via the WD 40 repeats and bound preferentially to a phosphorylated form of Notch 4 in cells . ^^^ We mapped the region of Notch 4 essential for SEL 10 binding to the C terminal region downstream of the ankyrin repeats . ^^^ When this C terminal fragment of Notch 4 was expressed in cells , it was highly labile but could be stabilized by the expression of dominant negative SEL 10 . ^^^ Ubiquitination of Notch 1 and Notch 4 intracellular domains in vitro was dependent on SEL 10 . ^^^ |
|
| Interacting proteins: Q99466 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Notch 4 , which is the product of the proto oncogene Int 3 and an endothelial cell specific mammalian isoform of Notch , accumulated in Fbw 7 ( / ) embryos , resulting in an increased expression of Hey 1 , which encodes a transcriptional repressor that acts downstream of Notch signaling and is implicated in vascular development . ^^^ Mammalian Fbw 7 thus appears to play an indispensable role in negative regulation of the Notch 4 Hey1 pathway and is required for vascular development . . ^^^ |
|
| Interacting proteins: Q99466 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Mouse embryo fibroblasts from Fbxw 7 deficient mice , or wild type mouse cells expressing Fbxw 7 small interfering RNA , have higher levels of Aurora A kinase , c Jun and Notch 4 , but not of cyclin E . ^^^ |
|
| Interacting proteins: Q99466 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| NA |
|