| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.50104948 |
| Skp 1 , Cdc 53 , and the F box protein Cdc 4 form a complex , SCFCdc 4 , which functions as a Sic 1 ubiquitin ligase ( E 3 ) in combination with the ubiquitin conjugating enzyme ( E 2 ) Cdc 34 and E 1 . 0.50104948^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| We have identified the yeast and human homologs of the SKP 1 gene as a suppressor of cdc 4 mutants and as a cyclin F binding protein . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| Hrt 1 assembles into recombinant SCF complexes and individually binds Cdc 4 , Cdc 53 and Cdc 34 , but not Skp 1 . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| Genetic data suggest that SIC 1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC 34 , CDC 4 , CDC 53 , SKP 1 , and CLN / CDC28 . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| In budding yeast , ubiquitination of the cyclin dependent kinase ( Cdk ) inhibitor Sic 1 is catalyzed by the E 2 ubiquitin conjugating enzyme Cdc 34 in conjunction with an E 3 ubiquitin ligase complex composed of Skp 1 , Cdc 53 and the F box protein , Cdc 4 ( the SCFCdc 4 complex ) . ^^^ We find that Skp 1 interacts with Cdc 53 in vivo , and that Skp 1 bridges Cdc 53 to three different F box proteins , Cdc 4 , Met 30 , and Grr 1 . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| A deletion allele of ENR 2 is lethal with temperature sensitive alleles of cdc 34 and enhances the phenotypes of cdc 4 , cdc 53 , and skp 1 , strongly implying that Rub1p conjugation to Cdc53p is required for optimal assembly or function of the E 3 complex SCFCdc 4 . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| One class of E 3 ligases is defined by the recently described SCF complexes , the archetype of which was first described in budding yeast and contains Skp 1 , Cdc 53 , and the F box protein Cdc 4 . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| In Saccharomyces cerevisiae , entry into S phase and separation of spindle pole bodies each require CDC 4 and CDC 34 , which encode components of an SCF ( Skp 1 cullin F box ) ubiquitin ligase , but a direct ( SCF ) connection to the spindle pole body is unknown . ^^^ |
|
| Interacting proteins: Q969H0 and P63208 |
Pubmed |
SVM Score :0.0 |
| The core SCF subunits Cdc 53 , Hrt 1 and Skp 1 were distributed in the nucleus and the cytoplasm , whereas the F box protein Cdc 4 was exclusively nuclear . ^^^ |
|