| Interacting proteins: P36956 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Fbw 7 also degrades nuclear SREBP1c and SREBP 2 , and inactivation of endogenous Fbw 7 results in stabilization of nuclear SREBP 1 and 2 , enhanced expression of SREBP target genes , enhanced synthesis of cholesterol and fatty acids , and enhanced receptor mediated uptake of LDL . ^^^ |
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| Interacting proteins: P36956 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Using a reconstituted ubiquitination system , we demonstrate that Fbw 7 mediated ubiquitination of SREBP 1 is dependent on its DNA binding activity . ^^^ |
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