| Interacting proteins: P24864 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| Cyclin E gene ( CCNE ) amplification and hCDC 4 mutations in endometrial carcinoma . ^^^ The present study has analysed amplification of the cyclin E gene ( CCNE ) and mutation in hCDC 4 , the gene coding for the F box protein , which tags phosphorylated cyclin E for proteosomal degradation , to ascertain whether these alterations might be responsible for cyclin E overexpression in ECs . ^^^ |
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| Interacting proteins: P24864 and Q969H0 |
Pubmed |
SVM Score :0.0 |
| We identified two potential mechanisms for this overexpression including the amplification / gain of CCNE 1 gene copies in the Panc 1 and Su86 . 86 cell lines and a novel somatic homozygous mutation ( H460R , in one of 11 pancreatic cancer xenografts having allelic loss ) in FBXW 7 , which was accompanied by cyclin E overexpression by immunohistochemistry . ^^^ |
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