| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| Mouse embryo fibroblasts from Fbxw 7 deficient mice , or wild type mouse cells expressing Fbxw 7 small interfering RNA , have higher levels of Aurora A kinase , c Jun and Notch 4 , but not of cyclin E . ^^^ |
|
| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| Fbxw 7 contributes to the ubiquitin mediated degradation of cyclin E , c Myc , Aurora A , Notch and c Jun , all of which appear to function as cell cycle promoters and oncogenic proteins . ^^^ |
|
| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| Fbw 7 depletion resulted in accumulation of phosphorylated c Jun , stimulation of AP 1 activity , and neuronal apoptosis . ^^^ We report that in neurons the stability of c Jun is regulated by the E 3 ligase SCF ( Fbw 7 ) , which ubiquitinates phosphorylated c Jun and facilitates c Jun degradation . ^^^ SCF ( Fbw 7 ) therefore antagonizes the apoptotic c Jun dependent effector arm of JNK signaling , allowing neurons to tolerate potentially neurotoxic JNK activity . . ^^^ |
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| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| The 5 Jun point mutation allows c Jun to escape GSK 3 dependent recognition and destruction by the Fbw 7 ubiquitin ligase . ^^^ Similar to c Myc , we report here that phosphorylation of c Jun by GSK 3 creates a high affinity binding site for the E 3 ligase Fbw 7 , which targets c Jun for polyubiquitination and proteasomal degradation . ^^^ These findings explain the enhanced stability and oncogenicity of 5 Jun relative to its cellular counterpart and reveal that GSK 3 and Fbw 7 coordinately regulate c Jun and c Myc . . ^^^ |
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| Interacting proteins: Q969H0 and P05412 |
Pubmed |
SVM Score :0.0 |
| The Fbw7 / hCdc4 F box protein was first recognized by its ability to bind cyclin E , and the SCF ( Fbw 7 ) is now known to target c Myc , c Jun and Notch for degradation in addition to its role in cyclin E proteolysis . ^^^ |
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