| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.53540599 |
| We suggest that interactions between c Myc and Fbw7gamma within the nucleolus regulate c Myc ' s growth promoting function and that c Myc activation is likely to be an important oncogenic consequence of Fbw 7 loss in cancers . . 0.53540599^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Cyclin E and c Myc degradation by SCF ( Fbxw 7 ) ] . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Archipelago ( AGO , also known as hCdc 4 , Fbw 7 , or Sel 10 ) is an F box containing component of the SCF complex implicated in the ubiquitination and proteolysis of cyclin E and c Myc , and found to be mutated in 16 % of endometrial carcinomas . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Here we present genetic and biochemical evidence that Archipelago ( Ago ) , the F box component of an SCF ubiquitin ligase and the Drosophila ortholog of a human tumor suppressor , negatively regulates the levels and activity of Drosophila Myc ( dMyc ) protein in vivo . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Two of these proteins , c Myc and cyclin E , are recognized by the Cdc 4 E3 ligase of the Skp1 / Cul1 / Rbx1 ( SCF ) complex . ^^^ SCF ( Cdc 4 ) binds to a similar phosphodegron sequence in c Myc and cyclin E proteins resulting in ubiquitylation and degradation of both proteins via the 26 S proteosome . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Three novel MYC interacting genes ( UBE2C , EMP 1 , and FBXW 7 ) with cancer related functions were identified as network constituents differentially expressed in gliomas , as was CD 151 as a new component of a network that mediates glioblastoma cell invasion . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Fbxw 7 contributes to the ubiquitin mediated degradation of cyclin E , c Myc , Aurora A , Notch and c Jun , all of which appear to function as cell cycle promoters and oncogenic proteins . ^^^ In the present study , we examined the abundance of cyclin E , c Myc and Aurora A in seven cancer cell lines , which harbor wild type ( three lines ) or mutant ( four lines ) Fbxw 7 . ^^^ Forced expression of Fbxw 7 reduced the levels of cyclin E , c Myc and Aurora A in the Fbxw 7 mutant cells . ^^^ In contrast , a decrease in the expression of cyclin E , c Myc or Aurora A by RNA interference significantly suppressed the rate of proliferation and anchorage independent growth of the Fbxw 7 mutant cells . ^^^ These findings thus suggest that the loss of Fbxw 7 results in accumulation of cyclin E , c Myc and Aurora A , all of which appear to be required for growth promotion of cancer cells . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| The Fbw 7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation dependent c Myc protein degradation . ^^^ We show here that Fbw 7 , a component of the SCF ( Fbw 7 ) ubiquitin ligase and a tumor suppressor , promotes proteasome dependent c Myc turnover in vivo and c Myc ubiquitination in vitro . ^^^ Phosphorylation of c Myc on threonine 58 ( T 58 ) by glycogen synthase kinase 3 regulates the binding of Fbw 7 to c Myc as well as Fbw 7 mediated c Myc degradation and ubiquitination . ^^^ T 58 is the most frequent site of c myc mutations in lymphoma cells , and our findings suggest that c Myc activation is one of the key oncogenic consequences of Fbw 7 loss in cancer . ^^^ Because Fbw 7 mediates the degradation of cyclin E , Notch , and c Jun , as well as c Myc , the loss of Fbw 7 is likely to elicit profound effects on cell proliferation during tumorigenesis . . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Similar to c Myc , we report here that phosphorylation of c Jun by GSK 3 creates a high affinity binding site for the E 3 ligase Fbw 7 , which targets c Jun for polyubiquitination and proteasomal degradation . ^^^ These findings explain the enhanced stability and oncogenicity of 5 Jun relative to its cellular counterpart and reveal that GSK 3 and Fbw 7 coordinately regulate c Jun and c Myc . . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| The Fbw7 / hCdc4 F box protein was first recognized by its ability to bind cyclin E , and the SCF ( Fbw 7 ) is now known to target c Myc , c Jun and Notch for degradation in addition to its role in cyclin E proteolysis . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Small inhibitory RNA induced silencing of GSK3beta prevents phosphorylation of MYC on T 58 , thereby inhibiting recognition of MYC by the E 3 ubiquitin ligase component FBW 7 . ^^^ Attenuating the GSK3beta FBW 7 axis results in stabilization of MYC , up regulation of surface levels of the TNF related apoptosis inducing ligand death receptor 5 , and potentiation of death receptor 5 induced apoptosis in vitro and in vivo . ^^^ These results identify GSK3beta and FBW 7 as potential cancer therapeutic targets and MYC as a critical substrate in the GSK3beta survival signaling pathway . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of c Myc on threonine 58 ( T 58 ) stimulates its degradation by the Fbw 7 SCF ubiquitin ligase . ^^^ We used a phosphorylation specific antibody raised against the c Myc T 58 region to attempt to identify other proteins regulated by the Fbw 7 pathway . ^^^ |
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| Interacting proteins: Q969H0 and P01106 |
Pubmed |
SVM Score :0.0 |
| Diminished F box levels resulted in reduced SCF activity , as evidenced by accumulation of two substrates of the F box protein Fbw 7 , cyclin E and c myc , in Csn 5 depleted cells . ^^^ |
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