| Interacting proteins: Q93038 and O95429 |
Pubmed |
SVM Score :0.0 |
| SODD also interacted with death receptor 3 ( DR 3 ) , another member of the TNF receptor superfamily . ^^^ |
|
| Interacting proteins: Q93038 and O95429 |
Pubmed |
SVM Score :0.0 |
| Several other members of the TNF superfamily , including Fas and death receptors ( DR ) 3 , 4 , and 5 , also contain intracellular death domains , but SODD only interacts with the death domain of DR 3 . ^^^ We therefore studied the expression of DR 3 in human kidney , and report that this death receptor is up regulated in renal tubular epithelial cells and endothelial cells of some interlobular arteries , in parallel with SODD , during acute transplant rejection . ^^^ In less severe rejection episodes , DR 3 and SODD were more focally induced , generally at sites of mononuclear cell infiltrates . ^^^ |
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| Interacting proteins: Q93038 and O95429 |
Pubmed |
SVM Score :0.0 |
| Besides TNFR 1 , death receptor 3 ( DR 3 ) , Hsp70 / Hsc70 , and Bcl 2 have been characterized as binding partners of SODD . ^^^ |
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| Interacting proteins: Q93038 and O95429 |
Pubmed |
SVM Score :0.0 |
| During camptothecin and etoposide ( VP 16 ) induced apoptosis in HL 60 cells , the expression level of cell death receptor 3 ( DR 3 ) , cell death receptor 4 ( DR 4 ) , and FAS remained mostly unchanged , whereas the expression of silencers of death domain ( SODD ) and FLICE inhibitory proteins , inhibitors of the cell death receptor signaling pathways , decreased substantially . ^^^ Taken together , these observations suggested that camptothecin and VP 16 induced rapid aggregation of DR 4 and DR 3 , but paradoxically , the importance of these events in signaling apoptosis is uncertain , because the kinetics of apoptosis were unaffected , even in the presence of a high expression level of SODD , FADD DN , TRADD ND , and DAP 3 DN . ^^^ |
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