| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.90071155 |
| Here , we show that HAUSP also interacts with Hdmx , resulting in its direct deubiquitination and stabilization . 0.90071155^^^ |
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| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.79971298 |
| Further insight into the mechanism by which ATM switches the interactions between HAUSP , Mdmx , Mdm 2 and p 53 , to favor p 53 activation may offer new tools for therapeutic intervention in the p 53 pathway for cancer treatment . . 0.79971298^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| Two other upstream regulators that regulate the stability of HDM 2 , PTEN and HAUSP , also were studied . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed to evaluate the protein expression of p 53 , HAUSP , mdm 2 , p 21 , and bax . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| We further show that this phenomenon occurs because HAUSP stabilizes Mdm 2 in a p 53 independent manner , providing an interesting feedback loop in p 53 regulation . ^^^ Notably , HAUSP is required for Mdm 2 stability in normal cells ; in HAUSP ablated cells , self ubiquitinated Mdm 2 becomes extremely unstable , leading to indirect p 53 activation . ^^^ Furthermore , this feedback regulation is specific to Mdm 2 ; in HeLa cells , where p 53 is preferentially degraded by viral E 6 dependent ubiquitination , depletion of HAUSP fails to activate p 53 . ^^^ This study provides an example of an ubiquitin ligase ( Mdm 2 ) that is directly regulated by a deubiquitinase ( HAUSP ) and also reveals a dynamic role of HAUSP in the p 53 Mdm2 pathway . . ^^^ |
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| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| HAUSP strongly stabilizes p 53 even in the presence of excess Mdm 2 , and also induces p 53 dependent cell growth repression and apoptosis . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that MDM 2 , rather than p 53 , is the substrate for HAUSP under physiologic conditions and document a fascinating and unexpected twist to the regulation of the p53 / MDM2 axis . . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| Factors such as HAUSP , p 14 ( ARF ) , and MdmX play important regulatory roles in p 53 ubiquitination / deubiquitination and their interplay with Mdm 2 and p 53 compound layers of complexity for regulating this important pathway . . ^^^ |
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| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| USP 7 ( also called HAUSP ) is a de ubiquitinating enzyme recently identified as a key regulator of the p 53 mdm2 pathway , which stabilizes both p 53 and mdm 2 . ^^^ USP 7 ( also called HAUSP ) is a de ubiquitinating enzyme recently identified as a key regulator of the p 53 mdm2 pathway , which stabilizes both p 53 and mdm 2 . ^^^ |
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| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| The ubiquitin specific protease , USP 7 , has key roles in the p 53 pathway whereby it stabilizes both p 53 and MDM 2 . ^^^ We show that the N terminal domain of USP 7 binds two closely spaced 4 residue sites in both p 53 and MDM 2 , falling between p 53 residues 359 367 and MDM 2 residues 147 159 . ^^^ Cocrystal structures with USP 7 were determined for both p 53 peptides and for one MDM 2 peptide . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| Herein , we deal with the post translational regulation of p 53 via its specific ubiquitinating enzymes ( Mdm 2 , Mdmx , COP 1 , Pirh 2 , ARF BP1 / Mule , and CHIP ) and a deubiquitinating enzyme , herpesvirus associated ubiquitin specific protease ( HAUSP ) . ^^^ |
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| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| Daxx simultaneously binds to Mdm 2 and the deubiquitinase Hausp , and it mediates the stabilizing effect of Hausp on Mdm 2 . ^^^ |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00987 and Q93009 |
Pubmed |
SVM Score :0.0 |
| NA |
|