| Here we show that DCX interacts with the ubiquitin specific protease Drosophila fat facets related on 10 chromosome ( DFFRX ) . ^^^ Interestingly , unlike beta catenin , no ubiquitinated forms of DCX could be detected , and indeed we show that DCX interacts with a novel recognition domain in DFFRX , located outside of its catalytic site . ^^^ We also show that DFFRX associates with microtubules at specific subcellular compartments , including those enriched in DCX . ^^^ These results thus suggest that in addition to vesicular trafficking , DCX may play a role in the regulation of cell adhesion via its interaction with DFFRX in migrating and differentiating neurons . . ^^^ |