| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.72881869 |
| By yeast two hybrid screening , the DIX domain of Dvl 1 was found to interact with Dvl 3 , a second mammalian Dishevelled relative . 0.72881869^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| In vitro translated beta catenin , Dvl 2 , and Dvl 3 are phosphorylated by CK 2 . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Dishevelled 1 ( DVL 1 ) , DVL 2 and DVL 3 are DIX domain proteins implicated in the WNT signaling pathway . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| We have isolated and characterized cDNA clones from two different human dsh homologous genes , designated as DVL 1 and DVL 3 . ^^^ DVL 1 and DVL 3 putative protein products show 64 % amino acid identity . ^^^ DVL 1 locus maps to chromosome 1p36 and DVL 3 to chromosome 3q27 . ^^^ DVL 1 and DVL 3 are members of a human dsh like gene family , which is probably involved in human development . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Utilizing RT PCR with degenerate primers , we isolated another member of the mouse Dishevelled ( Dvl ) gene family , Dvl 3 . ^^^ The Dvl 3 gene maps to mouse chromosome 16 . ^^^ In adult mice , Dvl 3 expression is widespread with highest levels exhibited in brain , ovary , and heart . ^^^ In embryos , Dvl 3 is expressed in every tissue between 7 . 5 and 9 . 5 days postcoitum , and by 10 . 5 days postcoitum highest expression was seen in the dorsal root ganglia , somites , limb buds , branchial arches , heart , gut and throughout the developing central nervous system . . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| We report the isolation and characterization of two new genomic loci corresponding to the mouse Dishevelled ( Dvl ) genes Dvl 2 and Dvl 3 . ^^^ Dvl 2 and Dvl 3 genomic clones were isolated from a mouse 129 strain gamma FIXII genomic library and have identical exon / intron organization to Dvl 1 . ^^^ Dvl 2 and Dvl 3 genomic clones were isolated from a mouse 129 strain gamma FIXII genomic library and have identical exon / intron organization to Dvl 1 . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| In the frizzled and dishevelled families we found FZD 1 , FZD 2 and DVL 3 transcripts in human adrenocortical RNA , and FZD 2 and DVL 3 in mouse adrenocortical RNA . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Analysis of freshly resected tumors and lung cancer cell lines demonstrate that Dvl 3 , a critical mediator of Wnt signaling , is overexpressed . ^^^ Specifically , Dvl 3 was overexpressed significantly in 75 % of fresh NSCLC microdissected samples compared to control paired matched normal lung samples . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the two known Vangl 2 loss of function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl 1 , Dvl 2 , and Dvl 3 . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| From this screen , both known components and previously uncharacterized regulators of this pathway were identified , including beta catenin , Dvl 1 , Dvl 3 , Fbxw 1 , Cul 1 , CK1epsilon , CK1delta , and gamma catenin . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Vangl 1 ( Strabismus 2 ) and Vangl 2 ( Strabismus 1 or Ltap ) are mammalian homologs of Drosophila Vang interacting with PRICKLE 1 , PRICKLE 2 , ANKRD 6 , DVL 1 , DVL 2 , DVL 3 , KAI 1 and MAGI 3 . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Human VANGL 1 , VANGL 2 ( Van Gogh homologs ) , CELSR 1 , CELSR 2 , CELSR 3 ( Starry night homologs ) , DVL 1 , DVL 2 , DVL 3 ( Dishevelled homologs ) , PRICKLE 1 , PRICKLE 2 ( Prickle homologs ) , and ANKRD 6 ( Diego homolog ) are core PCP signaling molecules . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| Like Celsr 3 , Dvl 3 and Prickle 2 were expressed more strongly in postmitotic neurons than in precursors . ^^^ Thus , the analogy between the PCP and Celsr 3 Fzd3 genetic networks is limited , but may include Dvl 3 and / or Prickle2 . . ^^^ |
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| Interacting proteins: Q92997 and O14640 |
Pubmed |
SVM Score :0.0 |
| WNT5A , WNT5B , WNT 11 , FZD 3 , FZD 6 , VANGL 1 , VANGL 2 , DVL 1 , DVL 2 , DVL 3 , PRICKLE 1 , PRICKLE 2 , ANKRD 6 , NKD 1 , NKD 2 , DAAM 1 , DAAM 2 , CELSR 1 , CELSR 2 , CELSR 3 , ROR 1 and ROR 2 are planar cell polarity ( PCP ) signaling molecules implicated in the regulation of cellular polarity , convergent extension , and invasion . ^^^ |
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