| Interacting proteins: Q7Z6A9 and Q92956 |
Pubmed |
SVM Score :1.2584796 |
| Here we show that HVEM binds BTLA with high affinity and can form a ternary complex with its known ligands homologous to lymphotoxin , showing inducible expression , and competing with herpes simplex virus glycoprotein D for HVEM , a receptor expressed by T lymphocytes ( LIGHT ) or lymphotoxin alpha and BTLA . 1.2584796^^^ |
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| Interacting proteins: Q7Z6A9 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The herpesvirus entry mediator ( HVEM ) , a member of the TNF receptor ( TNFR ) superfamily , can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand LIGHT ( TNFR superfamily 14 ) , or inhibitory signals through the Ig superfamily member B and T lymphocyte attenuator ( BTLA ) . ^^^ |
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| Interacting proteins: Q7Z6A9 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The exception is BTLA ( B and T lymphocyte attenuator ) , which instead interacts with the tumor necrosis factor receptor superfamily member HVEM ( herpes virus entry mediator ) . ^^^ |
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| Interacting proteins: Q7Z6A9 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The interaction between B and T lymphocyte attenuator ( BTLA ) , an inhibitory receptor whose extracellular domain belongs to the immunoglobulin superfamily , and herpesvirus entry mediator ( HVEM ) , a co stimulatory tumour necrosis factor receptor , is unique in that it is the only receptor ligand interaction that directly bridges these two families of receptors . ^^^ |
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| Interacting proteins: Q7Z6A9 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Here we show that BTLA does not bind B7x ; instead , we identify herpesvirus entry mediator ( HVEM ) as the unique BTLA ligand . ^^^ BTLA bound the most membrane distal cysteine rich domain of HVEM , distinct from regions where the ligands LIGHT and lymphotoxin alpha bound HVEM . ^^^ HVEM induced BTLA tyrosine phosphorylation and association of the tyrosine phosphatase SHP 2 and repressed antigen driven T cell proliferation , providing an example of reverse signaling to a non tumor necrosis factor family ligand . ^^^ The conservation of the BTLA HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and / or homeostasis in the immune response . . ^^^ |
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