| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| Estrogen receptor ( ER ) and 2P2 ( a mutated TR 2 with P box sequence of androgen receptor ) failed not only to bind to DR 4 TRE but also to recover this inhibitory effect of unliganded TRalpha 1 . ^^^ However , when T 3 was supplemented , estradiol ER competed for a full CAT activity while TR 2 showed an additive effect on the transcriptional activation . ^^^ These results indicate that DNA binding is essential for TR 2 to take action and fully functional liganded TR alpha 1 may rely on common factors shared with ER but not TR2 . . ^^^ Estrogen receptor ( ER ) and 2P2 ( a mutated TR 2 with P box sequence of androgen receptor ) failed not only to bind to DR 4 TRE but also to recover this inhibitory effect of unliganded TRalpha 1 . ^^^ |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| TR 2 orphan receptor ( TR 2 ) , a member of the nuclear receptor superfamily without identified ligands , is found to be expressed in the breast cancer cell lines and to function as a repressor to suppress ER mediated transcriptional activity . ^^^ Utilizing an interaction blocker , ER 6 ( amino acids 312 340 ) , responsible for TR 2 interaction , the suppression of ER by TR 2 could be reversed , suggesting that this suppression is conferred by the direct protein protein interaction . ^^^ Administration of antisense TR 2 , resulting in an enhancement of ER transcriptional activity in MCF 7 cells , indicates that endogenous TR 2 normally suppresses ER mediated signaling . ^^^ To gain insights into the molecular mechanism by which TR 2 suppresses ER , we found that TR 2 could interrupt ER DNA binding via formation of an ER TR 2 heterodimer that disrupted the ER homodimerization . ^^^ The suppression of ER transcription by TR 2 consequently caused the inhibition of estrogen induced cell growth and G ( 1 ) / S transition in estrogen dependent breast cancer cells . ^^^ |
|
| Interacting proteins: Q92956 and P03372 |
Pubmed |
SVM Score :0.0 |
| Fine structure and stereo images of the Golgi apparatus and endoplasmic reticulum ( ER ) in the subcommissural organ ( SCO ) cells were visualized by the application of zinc iodide osmium tetroxide ( ZIO ) impregnation , conventional electron microscopy and high voltage electron microscopy ( HVEM ) . ^^^ |
|