| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| A TR 2 Fc fusion protein inhibited a mixed lymphocyte reaction mediated proliferation suggesting that the receptor and / or its ligand play a role in T cell stimulation . . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The dimerization is mediated by the ligand binding domains , and the three leucine residues on helix 10 of TR 2 are critical for this interaction . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Herpesvirus entry mediator ligand ( HVEM L ) , a novel ligand for HVEM / TR2 , stimulates proliferation of T cells and inhibits HT 29 cell growth . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The mouse homologue of the human receptor interacting protein 140 ( RIP 140 ) was isolated from a mouse embryonic cDNA library in yeast two hybrid screening experiments by using the ligand binding domain ( LBD ) of nuclear orphan receptor TR 2 as the bait . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The orphan nuclear receptor TR 2 and its truncated isoform deleted in the ligand binding domain ( LBD ) were localized exclusively in the nuclei as revealed by two methods of detection . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that TR 6 specifically binds two cellular ligands , LIGHT ( herpes virus entry mediator ( HVEM ) L ) and Fas ligand ( FasL / CD95L ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| When we analyzed these peptides for the ability to interfere with HveA binding to its natural ligand LT alpha , we found that BP 1 inhibited the interaction of cellular LT alpha with HveA . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| In vitro binding experiments demonstrated that TRDL 1alpha coprecipitated Fas and HVEM and suggested TRDL 1alpha as an alternate ligand for these receptors . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a tumor necrosis factor ( TNF ) ligand superfamily member , which binds two known cellular receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HveA ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the tumor necrosis factor superfamily and is the ligand for LT betaR , HVEM , and decoy receptor 3 . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Here we describe the reciprocal regulation of the recently identified TNFR superfamily member herpes virus entry mediator ( HVEM ) ( TR 2 ) and its ligand LIGHT ( TL 4 ) on T cells following activation and the mechanism of this process . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that binding of a ligand to HveA may alter the conformation of this receptor , thereby affecting its interaction with its other ligands . . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Recombinant , soluble LIGHT ( HVEM ligand ) induces increased IL 8 secretion and growth arrest in A 375 melanoma cells . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| A combination of in vivo and in vitro assays was employed to describe the ligand independent interaction of the orphan nuclear receptor TR 2 and histone deacetylase proteins . ^^^ Dissection of TR 2 domains showed that the DNA binding domain of the receptor was responsible for interaction with both histone deacetylases 3 and 4 in glutathione S transferase pull down assays , while the ligand binding domain did not interact . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor receptor and ligand superfamily family members TNFRSF 14 and LIGHT : new players in human atherogenesis . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The recently described tumor necrosis factor ( TNF ) family member LIGHT ( herpes virus entry mediator [ HVEM ] L / TNFSF14 ) , a ligand for the lymphotoxin ( LT ) beta receptor , HVEM , and DcR 3 , was inactivated in the mouse . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a tumor necrosis factor ( TNF ) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator ( HVEM ) and the lymphotoxin beta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Affected receptors include Fas , TRAIL ( TNF related apoptosis inducing ligand ) receptor 1 ( TR 1 ) , TR 2 , and epidermal growth factor receptor ( EGFR ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| To avoid these tumorigenic effects , we studied an alternate way of tumor cell stimulation by homologous to lymphotoxin , inducible expression , competing for GpD of herpesvirus , which binds to the herpesvirus entry mediator ( HVEM ) , and is expressed on T lymphocytes ( LIGHT ) , the ligand for HVEM , a new member of the tumor necrosis factor ( TNF ) / TNF receptor ( R ) family . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor superfamily member LIGHT ( also known as TNFSF 14 ) is a ligand of stromal cell expressed lymphotoxin beta receptor and T cell expressed herpes viral entry mediator ( HVEM ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Here we show that BTLA does not bind B7x ; instead , we identify herpesvirus entry mediator ( HVEM ) as the unique BTLA ligand . ^^^ HVEM induced BTLA tyrosine phosphorylation and association of the tyrosine phosphatase SHP 2 and repressed antigen driven T cell proliferation , providing an example of reverse signaling to a non tumor necrosis factor family ligand . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Antibody to HVEM , or its viral ligand gD , coimmunoprecipitated several similar proteins . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Inhibition of LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) / herpes simplex virus entry mediator ( HVEM ) and LIGHT / lymphotoxin beta receptor ( LT beta R ) interactions decreases mortality in MHC class 1 and 2 disparate graft vs host disease ( GVHD ) . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The herpesvirus entry mediator ( HVEM ) , a member of the TNF receptor ( TNFR ) superfamily , can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand LIGHT ( TNFR superfamily 14 ) , or inhibitory signals through the Ig superfamily member B and T lymphocyte attenuator ( BTLA ) . ^^^ |
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| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Preligand assembly domain mediated ligand independent association between TRAIL receptor 4 ( TR 4 ) and TR 2 regulates TRAIL induced apoptosis . ^^^ The `` decoy receptors ' ' TRAIL R 3 ( TR 3 ) and TRAIL R 4 ( TR 4 ) were believed to negatively regulate TRAIL induced cytotoxicity by competing for ligand binding with TRAIL R 1 ( TR 1 ) and TRAIL R 2 ( TR 2 ) . ^^^ In primary CD 8 ( + ) T cells , which express only TR 2 and TR 4 and are resistant to TRAIL induced apoptosis , stimulation with phorbol myristate acetate abrogated the ligand independent interaction between TR 2 and TR 4 and enhanced their sensitivity to TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The interaction between B and T lymphocyte attenuator ( BTLA ) , an inhibitory receptor whose extracellular domain belongs to the immunoglobulin superfamily , and herpesvirus entry mediator ( HVEM ) , a co stimulatory tumour necrosis factor receptor , is unique in that it is the only receptor ligand interaction that directly bridges these two families of receptors . ^^^ As we discuss , recent studies show that engagement of HVEM with its endogenous ligand ( LIGHT ) from the tumour necrosis factor family induces a powerful immune response , whereas HVEM interactions with BTLA negatively regulate T cell responses . . ^^^ |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|