| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :1.277418 |
| Here , we demonstrate that HVEM binds two cellular ligands , secreted lymphotoxin alpha ( LTalpha ) and LIGHT , a new member of the TNF superfamily . 1.277418^^^ HSV 1 gD inhibits the interaction of HVEM with LIGHT , and LIGHT and gD interfere with HVEM dependent cell entry by HSV 1 . 0.5884174^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.52132454 |
| Our data suggest that TR 6 inhibits the interactions of LIGHT with HVEM / TR2 and LTbetaR , thereby suppressing LIGHT mediated HT 29 cell death . 0.52132454^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :1.3162123 |
| Here we show that HVEM binds BTLA with high affinity and can form a ternary complex with its known ligands homologous to lymphotoxin , showing inducible expression , and competing with herpes simplex virus glycoprotein D for HVEM , a receptor expressed by T lymphocytes ( LIGHT ) or lymphotoxin alpha and BTLA . 1.3162123^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :1.0819443 |
| As we discuss , recent studies show that engagement of HVEM with its endogenous ligand ( LIGHT ) from the tumour necrosis factor family induces a powerful immune response , whereas HVEM interactions with BTLA negatively regulate T cell responses . . 1.0819443^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Herpesvirus entry mediator ligand ( HVEM L ) , a novel ligand for HVEM / TR2 , stimulates proliferation of T cells and inhibits HT 29 cell growth . ^^^ One of these , which we designated HVEM L , specifically bound to HVEM Fc with an affinity of 44 nM . ^^^ HVEM L mRNA is expressed in spleen , lymph nodes , macrophages , and T cells and encodes a 240 amino acid protein . ^^^ Herpesvirus entry mediator ligand ( HVEM L ) , a novel ligand for HVEM / TR2 , stimulates proliferation of T cells and inhibits HT 29 cell growth . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Three way observations of the identical cell structures within the same sections by light microscopy , HVEM and SEM . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| These polymers are prepared as 50 100nm thin films suitable as substrates for consecutive light microscopy , high voltage electron microscopy ( HVEM ) , and SEM . 18nm colloidal gold coupled to fibrinogen permits visualization of that receptor ' s motility in living cells by video enhanced light microscopy . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Digestion of prey in foraminifera is not anomalous : a correlation of light microscopic , cytochemical , and HVEM technics to study phagotrophy in two allogromiids . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Light and high voltage electron microscopy ( HVEM ) procedures have been employed to examine the processes regulating saltatory motion in neurons . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Dendritic spines of rat neostriatal neurons were examined by light microscopy and high voltage stereo electron microscopy ( HVEM ) following selective staining by intracellular microinjection of horseradish peroxidase . ^^^ Light microscopic and HVEM examination of spiny dendrites and quantitative analysis of serial thin sections from normal material revealed no distinct spine types but rather continuous and independent variation of spine head diameter , stalk diameter , and stalk length . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Light microscopic ( LM ) and high voltage electron microscopic ( HVEM ) techniques were used . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Heavy and light chain cDNAs were amplified by PCR , fused to a signal sequence for secretion and cloned behind CaMV 35S and TR 2 ' promoters in a single T DNA . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| In addition to gD binding to HveA , the latter has been shown to interact with proteins of tumor necrosis factor receptor associated factor family , lymphotoxin alpha ( LT alpha ) , and a membrane associated protein referred to as LIGHT . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a tumor necrosis factor ( TNF ) ligand superfamily member , which binds two known cellular receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HveA ) . ^^^ Receptor binding residues via LIGHT were identified by introducing point mutations in the A ' > A ' ' and D > E loops of LIGHT , which altered binding to LTbetaR and HveA . ^^^ One mutant of LIGHT exhibits selective binding to HveA and is inactive triggering cell death in HT29 . 14s cells or induction of ICAM 1 in fibroblasts . ^^^ Studies with HveA or LTbetaR specific antibodies further indicated that HveA does not contribute , either cooperatively or by direct signaling , to the death pathway activated by LIGHT . ^^^ LTbetaR , not HveA , recruits TNF receptor associated factor 3 ( TRAF 3 ) , and LIGHT induced death is blocked by a dominant negative TRAF 3 mutant . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the tumor necrosis factor superfamily and is the ligand for LT betaR , HVEM , and decoy receptor 3 . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Here we describe the reciprocal regulation of the recently identified TNFR superfamily member herpes virus entry mediator ( HVEM ) ( TR 2 ) and its ligand LIGHT ( TL 4 ) on T cells following activation and the mechanism of this process . ^^^ T cell activation resulted in down regulation of HVEM and up regulation of LIGHT , which were both more pronounced in CD 8 ( + ) than CD 4 ( + ) T lymphocytes . ^^^ The analysis of HVEM and LIGHT mRNA showed an increase in the steady state level of both mRNAs following stimulation . ^^^ HVEM down regulation did not rely on de novo protein synthesis , in contrast to the partial dependence of LIGHT induction . ^^^ Matrix metalloproteinase inhibitors did not modify HVEM expression , but did enhance LIGHT accumulation at the cell surface . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Recombinant , soluble LIGHT ( HVEM ligand ) induces increased IL 8 secretion and growth arrest in A 375 melanoma cells . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that islet TNF alpha receptor 1 ( p 55 ) influences the expression of LIGHT ( TNFSF 14 ) , a TNF family member with both cytolytic and costimulatory properties , on BDC2 . 5 T cells and the expression of its receptor HVEM ( TNFRSF 14 ) by islets , indicating a role for LIGHT HVEM interactions in autoimmune diabetes . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , which binds two known receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / TR2 . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor superfamily 14 ( TNFRSF 14 ) is the cellular receptor for TNF superfamily 14 ( LIGHT ) . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor receptor and ligand superfamily family members TNFRSF 14 and LIGHT : new players in human atherogenesis . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The three HveA receptor ligands , gD , LT alpha and LIGHT bind to distinct sites on HveA . ^^^ The herpes virus entry mediator A ( HveA ) , a member of the tumor necrosis factor receptor ( TNFR ) superfamily , interacts with three different protein ligands ; lymphotoxin alpha ( LT alpha ) and LIGHT ( LIGHT stands for lymphotoxin homolog , which exhibits inducible expression and competes with HSV glycoprotein D for HveA and is expressed on T lymphocytes ) from the host and the herpes simplex virus ( HSV ) surface glycoprotein gD . ^^^ It has been reported that the gD binding site on HveA is located within the receptor ' s two N terminal CRP domains , and that gD and LIGHT compete for their binding to HveA . ^^^ Two HveA peptide ligands ( BP 1 and BP 2 ) that differentially inhibit binding of soluble gD and LT alpha to the receptor were also used to demonstrate that gD , LIGHT and LT alpha bind to distinct sites on the receptor . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| According to flow cytometry , recombinant human TR 6 Fc binds to human LIGHT expressed on 293 cells or on activated human T cells and competes with the LIGHT receptor TR 2 for the binding to LIGHT on these cells . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Modulation of LIGHT HVEM costimulation prolongs cardiac allograft survival . ^^^ LIGHT ( TNFSF 14 ) , a tumor necrosis factor superfamily member expressed by activated T cells , binds to herpes virus entry mediator ( HVEM ) which is constitutively expressed by T cells and costimulates T cell activation in a CD 28 independent manner . ^^^ Given interest in regulating the effector functions of T cells in vivo , we examined the role of LIGHT HVEM costimulation in a murine cardiac allograft rejection model . ^^^ Normal hearts lacked LIGHT or HVEM mRNA expression , but allografts showed strong expression of both genes from day 3 after transplant , and in situ hybridization and immunohistology localized LIGHT and HVEM to infiltrating leukocytes . ^^^ Our data suggest that T cell to T cell mediated LIGHT / HVEM dependent costimulation is a significant component of the host response leading to cardiac allograft rejection . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The recently described tumor necrosis factor ( TNF ) family member LIGHT ( herpes virus entry mediator [ HVEM ] L / TNFSF14 ) , a ligand for the lymphotoxin ( LT ) beta receptor , HVEM , and DcR 3 , was inactivated in the mouse . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT , a newly identified TNF family member , is a costimulatory molecule for T cells and binds to LTbetaR and herpes virus entry mediator ( HVEM ) in vitro . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of tumor necrosis factor ( TNF ) superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / ATAR / TR2 , both of which lack the cytoplasmic sequence termed the `` death domain . ' ' The present study has demonstrated that LIGHT inhibits TNFalpha mediated apoptosis of human primary hepatocytes sensitized by actinomycin D ( ActD ) , but not Fas or TRAIL mediated apoptosis . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes . mRNA encoding LIGHT ( homologous to lymphotoxins , exhibits inducible expression , competes with herpes simplex virus glycoprotein D for HVEM , a receptor expressed by T lymphocytes ) , a member of the tumor necrosis factor superfamily of ligands , as well as mRNAs encoding LIGHT receptors [ HVEM , LTbetaR , and TR 6 ( DcR 3 ) ] are present in placentas and cytotrophoblast cells at term . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| In this review , we will discuss the regulatory mechanisms of TNF receptor / ligand family members , such as HVEM / LIGHT , 4 1BB / 4 1BBL , and GITR / GITRL that regulate T and B cell functions and participate in the process of inflammatory diseases . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| TR 6 can interfere with FasL or LTbetaR mediated apoptosis ; it can also inhibit T cell costimulation by blocking the two way signaling between TR 2 and LIGHT , and the one way signaling from TL1A to DR 3 . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| We also show that LTbetaR Ig treated R 16 injected rats had a significantly decreased T cell response to R 16 and that herpesvirus entry mediator ( HVEM ) Ig , a fusion protein that blocks LIGHT , also inhibited disease development . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT HVEM signaling and the regulation of T cell mediated immunity . ^^^ LIGHT is a tumor necrosis factor ( TNF ) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator ( HVEM ) and the lymphotoxin beta receptor ( LTbetaR ) . ^^^ This review will present a summary of recent advances made regarding the immunobiology of the LIGHT HVEM and LTbetaR systems . ^^^ These results provide an encouraging profile for the LIGHT HVEM LTbetaR axis as a potential target for controlling cellular immune reactions . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| It can also inhibit T cell activation by interfering with two way T cell costimulation between LIGHT and HveA . ^^^ Such an effect could also be observed in T cells pretreated with soluble or solid phase HveA Fc or anti LIGHT mAb , suggesting that LIGHT reverse signaling was likely responsible for chemotaxis inhibition . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| To avoid these tumorigenic effects , we studied an alternate way of tumor cell stimulation by homologous to lymphotoxin , inducible expression , competing for GpD of herpesvirus , which binds to the herpesvirus entry mediator ( HVEM ) , and is expressed on T lymphocytes ( LIGHT ) , the ligand for HVEM , a new member of the tumor necrosis factor ( TNF ) / TNF receptor ( R ) family . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor superfamily member LIGHT ( also known as TNFSF 14 ) is a ligand of stromal cell expressed lymphotoxin beta receptor and T cell expressed herpes viral entry mediator ( HVEM ) . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The tumor necrosis factor ( TNF ) superfamily member LIGHT , which binds herpes virus entry mediator ( HVEM ) and lymphotoxin beta receptor ( LTbetaR ) , plays important roles in regulating the immune response . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| This review focuses on the role of homologous to lymphotoxin , exhibits inducible expression , competes with herpesvirus glycoprotein D for HVEM on T cells ( LIGHT ) in T cell immunity and T cell mediated diseases . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The LIGHT / HVEM system [ homologous to lymphotoxin , inducible expression , competing for GpD of herpes virus , that binds to the herpes virus entry mediator ( HVEM ) , and is expressed on activated T lymphocytes ) focused our attention since HVEM has a large distribution that , in addition to T cells , DC or NK , includes tumor and normal B lymphocytes . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| BTLA bound the most membrane distal cysteine rich domain of HVEM , distinct from regions where the ligands LIGHT and lymphotoxin alpha bound HVEM . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT ( TNFSF 14 ) and its receptor TR 2 ( TNFRSF 14 ) are known to have pro inflammatory activities in foam cells of atherosclerotic plaques . ^^^ We tested a hypothesis that LIGHT and TR 2 are involved in activation of monocyte / macrophages in RA synovium . ^^^ Immunohistochemical analysis of RA synovial tissue samples revealed that both LIGHT and TR 2 are expressed in CD 68 positive macrophages . ^^^ These data indicate that LIGHT and TR 2 expressed in macrophages are involved in the pathogenesis of RA by inducing the expression pro inflammatory cytokines and matrix degrading enzymes . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Inhibition of LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) / herpes simplex virus entry mediator ( HVEM ) and LIGHT / lymphotoxin beta receptor ( LT beta R ) interactions decreases mortality in MHC class 1 and 2 disparate graft vs host disease ( GVHD ) . ^^^ An inhibitor protein of LIGHT and LT alpha beta 2 ( LT beta R Ig ) and an inhibitor protein of LIGHT ( HVEM Ig ) caused similar decreases in alloresponses of control B 6 or B6 . 129S1 IL12rb2 ( tm1Jm ) ( B6 . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells . ^^^ LIGHT is a member of the TNF superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator ( HVEM ) , and decoy receptor 3 ( DcR 3 ) . ^^^ LIGHT can induce either cell death and / or NF kappaB activation via its interaction with LTbetaR and / or HVEM . ^^^ We demonstrated that both LTbetaR and HVEM , but not DcR 3 , are present in HUVECs , and LIGHT can induce the secretion of chemokines ( IL 8 and GRO alpha ) , cell surface expression of adhesion molecules ( ICAM 1 and VCAM 1 ) , PGI 2 release , and COX 2 expression . ^^^ These results indicate that both LTbetaR and HVEM can discriminatively mediate the expression of different genes in HUVECs , and suggest that LIGHT is a proinflammatory cytokine . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Lymphtoxin beta receptor Ig ameliorates TNBS induced colitis via blocking LIGHT / HVEM signaling . ^^^ To address the role of LIGHT / HVEM signaling in colonic inflammation , an experimental colitis model induced by rectal administration of trinitrobenzene sulfonic acid ( TNBS ) was given a soluble LTbetaR Ig fusion protein as a competitive inhibitor of LIGHT / HVEM pathway . ^^^ We postulated that blockade of LIGHT / HVEM signaling by LTbetaR Ig may ameliorate TNBS induced colitis by down regulating LIGHT expression , and therefore we envision that LTbetaR Ig would prove to a promising strategy for the clinical treatment of inflammatory bowel disease . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Previous studies showed that homologous to lymphotoxin , exhibits inducible expression , competes with herpesvirus glycoprotein D for HVEM on T cells ( LIGHT ) transgenic ( Tg ) mice develop autoimmunity including intestinal inflammation with a variable time course . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| In addition , HSV 1 envelope glycoproteins can also bind the LIGHT receptor , herpes virus entry mediator ( HVEM ) , and activate similar downstream signalling pathways in DC . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The herpesvirus entry mediator ( HVEM ) , a member of the TNF receptor ( TNFR ) superfamily , can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand LIGHT ( TNFR superfamily 14 ) , or inhibitory signals through the Ig superfamily member B and T lymphocyte attenuator ( BTLA ) . ^^^ The BTLA binding site on HVEM overlaps with the binding site for the herpes simplex virus 1 envelope glycoprotein D , but is distinct from where LIGHT binds , yet glycoprotein D inhibits the binding of both ligands , potentially nullifying the pathway . ^^^ UL 144 binds BTLA , but not LIGHT , and inhibits T cell proliferation , selectively mimicking the inhibitory cosignaling function of HVEM . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Light scattering analysis demonstrates that the extracellular domain of BTLA is monomeric and that BTLA and HVEM form a 1 : 1 complex . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| Herpesvirus entry mediator ( HVEM ) is expressed on NK cells , and its engagement with LIGHT mediates NK cell activation . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM . ^^^ We found that the herpes virus entry mediator ( HVEM ) was highly expressed in monocytes and neutrophils , and its interaction with `` homologous to lymphotoxins , shows inducible expression , and competes with herpes simplex virus glycoprotein D for HVEM / tumor necrosis factor ( TNF ) related 2 ' ' ( LIGHT ) enhanced bactericidal activity against Listeria monocytogenes and Staphylococcus aureus . ^^^ The LIGHT HVEM interaction increased levels of phagocytosis , interleukin ( IL ) 8 , TNF alpha , nitric oxide ( NO ) , and reactive oxygen species ( ROS ) in monocytes and neutrophils . ^^^ Anti HVEM monoclonal antibody was able to block LIGHT induced bactericidal activity , cytokine production ( IL 8 and TNF alpha ) , and ROS generation . ^^^ Our results indicate that the LIGHT / HVEM interaction in monocytes and neutrophils contributes to antibacterial activity . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| LIGHT ( which is homologous to lymphotoxins , shows inducible expression , and competes with HSV glycoprotein D for HVEM , a receptor expressed by T lymphocytes [ Genome Database designation , TNFSF 14 ] ) , a newly identified member of the TNF superfamily , is up regulated upon activation of T cells . ^^^ LIGHT plays an important role in the T cell mediated tumor and graft versus host disease via LIGHT / HVEM / LT beta R signaling . ^^^ Thus , this MAb may be the basis for detection of LIGHT protein in tissue or cell and be beneficial for the study of LIGHT / HVEM / LT beta R pathway . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor family ligands , LIGHT ( lymphotoxin like , exhibits inducible expression and competes with HSV glycoprotein D for HVEM , a receptor expressed by T lymphocytes ) , 4 1BBL and CD 70 , are found in the same gene cluster on mouse chromosome 17 . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| TL 2 , TR 1 , TR 2 and TR 3 were recently described by others as TRAIL / Apo 2L , OPG , HVEM and DR3 / WSL 1 / Apo 3 / TRAMP / LARD , respectively . . ^^^ |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43557 and Q92956 |
Pubmed |
SVM Score :0.0 |
| NA |
|