| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :1.2354528 |
| By contrast , E selectin binds with normal efficiency to ESL 1 on Fuc TVII deficient neutrophils but exhibits an 80 % reduction in its ability to bind ESL 1 isolated from Fuc TIV deficient neutrophils . 1.2354528^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| The E selectin ligand ESL 1 is a variant of a receptor for fibroblast growth factor . ^^^ Here we report the isolation of a mouse complementary DNA for this E selectin ligand ( ESL 1 ) . ^^^ Fucosylation of ESL 1 is imperative for affinity isolation with E selectin IgG . ^^^ A fucosylated , recombinant antibody like form of ESL 1 , but not of L selectin , supports adhesion of E selectin transfected Chinese hamster ovary cells . ^^^ Antibodies against ESL 1 block the binding of mouse myeloid cells to E selectin . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| MG 160 is a conserved membrane sialoglycoprotein of the Golgi apparatus of most cells displaying over 90 % amino acid sequence identities with two apparently unrelated molecules , namely CFR , a chicken fibroblast growth factor receptor , and ESL 1 , a ligand for E selectin ( Gonatas et al . , J . ^^^ MG 160 , a membrane protein of the Golgi apparatus which is homologous to a fibroblast growth factor receptor and to a ligand for E selectin , is found only in the Golgi apparatus and appears early in chicken embryo development . ^^^ MG 160 is a conserved membrane sialoglycoprotein of the Golgi apparatus of most cells displaying over 90 % amino acid sequence identities with two apparently unrelated molecules , namely CFR , a chicken fibroblast growth factor receptor , and ESL 1 , a ligand for E selectin ( Gonatas et al . , J . ^^^ These results indicate that MG 160 is a primordial protein of the Golgi apparatus and are consistent with the hypothesis that the binding of MG 160 to fibroblast growth factors and E selectin is not related to the still unknown principal function of MG 160 in the Golgi apparatus . . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Assignment of the GLG 1 gene for MGF 160 , a fibroblast growth factor and E selectin binding membrane sialoglycoprotein of the Golgi apparatus , to chromosome 16q22 q 23 by fluorescence in situ hybridization . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| The E selectin ligand 1 is selectively activated in Chinese hamster ovary cells by the alpha ( 1 , 3 ) fucosyltransferases 4 and 7 . ^^^ The E selectin ligand 1 ( ESL 1 ) has recently been identified as the major ligand on mouse neutrophils using a recombinant antibody like form of E selectin as affinity probe . ^^^ Since ESL 1 is endogenously expressed in Chinese hamster ovary ( CHO ) cells in a non E selectin binding form , which can become activated upon transfection of a fucosyltransferase ( FucT ) , we analyzed various CHO cell clones , each overexpressing one of seven different fucosyltransferases , by affinity isolation experiments with E selectin IgG . ^^^ These data suggest that , dependent on the type of fucosyltransferase , ESL 1 is a strongly preferred target molecule for the generation of E selectin binding carbohydrate modifications . . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of MG 160 , a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus , is more than 90 % identical with CFR , a fibroblast growth factor ( FGF ) binding protein of chicken membranes , and with ESL 1 , a ligand for E selectin of plasma membranes of myeloid cells ; furthermore , MG 160 , isolated by immunoaffinity chromatography from rat brain membranes , binds to basic FGF . ^^^ Cloning and sequence analysis of the human MG 160 , a fibroblast growth factor and E selectin binding membrane sialoglycoprotein of the Golgi apparatus . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| The E selectin ligand 1 ( ESL 1 ) is a high affinity glycoprotein ligand which participates in the binding of mouse myeloid cells to E selectin . ^^^ The E selectin ligand ESL 1 is located in the Golgi as well as on microvilli on the cell surface . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| MG 160 , a type 1 membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus , shows high homology ( over 90 % ) with CFR , a fibroblast growth factor receptor , and ESL 1 , an E selectin ligand of the cell surface of murine myeloid cells . ^^^ MG 160 , a type 1 membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus , shows high homology ( over 90 % ) with CFR , a fibroblast growth factor receptor , and ESL 1 , an E selectin ligand of the cell surface of murine myeloid cells . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Latent transforming growth factor beta complex in Chinese hamster ovary cells contains the multifunctional cysteine rich fibroblast growth factor receptor , also termed E selectin ligand or MG 160 . ^^^ Purification of the 140 kDa component , termed latent TGF beta complexed protein 1 ( LTCP 1 ) , followed by amino acid sequencing and cDNA cloning from a CHO cell cDNA library , revealed that it is a hamster counterpart of a previously identified , multifunctional protein known as chicken cysteine rich fibroblast growth factor ( FGF ) receptor , mouse E selectin ligand and rat MG 160 ( a 160 kDa membrane sialoglycoprotein of the Golgi apparatus ) . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Finally , E selectin ligand 1 apparently may have a minimal role , if any , in lymphocyte / E selectin interactions , since a polyclonal anti E selectin ligand 1 serum stained a minimal number of cutaneous lymphocyte associated Ag positive human lymphocytes and bovine gamma delta T cells . . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| MG 160 is an intrinsic type 1 cysteine rich membrane sialoglycoprotein that resides in the medial cisternae of the Golgi apparatus , highly homologous to CFR , chicken fibroblast growth factor receptor , and ESL 1 , E selectin ligand . ^^^ MG 160 is an intrinsic type 1 cysteine rich membrane sialoglycoprotein that resides in the medial cisternae of the Golgi apparatus , highly homologous to CFR , chicken fibroblast growth factor receptor , and ESL 1 , E selectin ligand . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| MG 160 , a type 1 cysteine rich membrane sialoglycoprotein residing in the medial cisternae of the rat Golgi apparatus , is highly homologous to CFR , a fibroblast growth factor receptor , and ESL 1 , an E selectin ligand located at the cell surface of mouse myeloid cells and recently detected in the Golgi apparatus as well . ^^^ MG 160 , a type 1 cysteine rich membrane sialoglycoprotein residing in the medial cisternae of the rat Golgi apparatus , is highly homologous to CFR , a fibroblast growth factor receptor , and ESL 1 , an E selectin ligand located at the cell surface of mouse myeloid cells and recently detected in the Golgi apparatus as well . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Structure of the murine E selectin ligand 1 ( ESL 1 ) gene and assignment to Chromosome 8 . ^^^ A 150 kDa glycoprotein designated in the mouse as E selectin ligand 1 ( ESL 1 ; gene symbol Selel ) was first isolated based on its ability to function as a ligand for E selectin . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Affinity , kinetics , and thermodynamics of E selectin binding to E selectin ligand 1 . ^^^ It recognizes the glycoprotein E selectin ligand 1 ( ESL 1 ) as a major binding partner on mouse myeloid cells . ^^^ Using surface plasmon resonance , we measured the kinetics and affinity of binding of monomeric E selectin to ESL 1 isolated from mouse bone marrow cells . ^^^ E selectin bound to ESL 1 with a fast dissociation rate constant of 4 . 6 s ( 1 ) and a calculated association rate constant of 7 . 4 10 10 ( 4 ) m ( 1 ) s ( 1 ) . ^^^ The affinity of the E selectin ESL 1 interaction did not change significantly when the temperature was varied from 5 degrees C to 37 degrees C , indicating that the enthalpic contribution to the binding is small at physiological temperatures , and that , in contrast to typical protein carbohydrate interactions , binding is driven primarily by favorable entropic changes . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of an insect homologue of the vertebrate Golgi apparatus protein 1 ( MG 160 / cysteine rich fibroblast growth factor receptor / E selectin ligand 1 / latent transforming growth factor beta complex protein 1 ) with a Golgi specific monoclonal antibody . ^^^ These findings supported that all of these genes actually composed a single gene , which encoded an orthologous protein to a vertebrate Golgi resident protein , Golgi apparatus protein 1 , also called cysteine rich FGF receptor , E selectin ligand 1 , or latent TGF beta complex protein 1 . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| A novel isoform of human Golgi complex localized glycoprotein 1 ( also known as E selectin ligand 1 , MG 160 and cysteine rich fibroblast growth factor receptor ) targets differential subcellular localization . ^^^ Previously , a putative murine E selectin ligand 1 ( ESL 1 ) was identified and found to be identical to Golgi complex localized glycoprotein 1 ( GLG 1 ) , also known as MG 160 , and to a previously identified basic fibroblast growth factor ( bFGF ) binding protein known as cysteine rich FGF receptor ( CFR ) . ^^^ |
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| Interacting proteins: P16581 and Q92896 |
Pubmed |
SVM Score :0.0 |
| Identification of leukocyte E selectin ligands , P selectin glycoprotein ligand 1 and E selectin ligand 1 , on human metastatic prostate tumor cells . ^^^ Interestingly , we also found that human prostate tumor cells derived from bone , lymph node , and brain metastases expressed another leukocyte E selectin ligand , E selectin ligand 1 ( ESL 1 ) . ^^^ |
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