| In view of proteolytic degradation , we have found that the serine protease neurosin ( kallikrein 6 ) degrades alpha synuclein and co localizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions . ^^^ Alpha synuclein degradation by serine protease neurosin : implication for pathogenesis of synucleinopathies . ^^^ In vitro study showed that neurosin prevented alpha synuclein polymerization by reducing the amount of monomer and also by generating fragmented alpha synucleins that themselves inhibited the polymerization . ^^^ Upon cellular stress , neurosin was released from mitochondria to the cytosol , which resulted in the increase of degraded alpha synuclein species . ^^^ Down regulation of neurosin caused accumulation of alpha synuclein within cultured cells . ^^^ |