| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.5440085 |
| The Arf like GTPase , Arl 1 , has been shown to mediate TGN recruitment of p230 / golgin245 and golgin 97 by interaction with their GRIP domains ; however , it is not known whether all the TGN golgins bind to Arl 1 and whether they are all recruited to the same or different TGN domains . 0.5440085^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| Interaction of Arl 1 GTP with GRIP domains recruits autoantigens Golgin 97 and Golgin 245 / p230 onto the Golgi . ^^^ Arl 1 GTP interacts with the GRIP domains of Golgin 97 and Golgin 245 , a process dependent on conserved residues of the GRIP domains that are important for Golgi targeting . ^^^ Arl 1 GTP mediates Golgi recruitment of Golgin 97 in a switch 2 dependent manner , whereas tethering Arl 1 GTP onto endosomes can mediate endosomal targeting of Golgin 97 . ^^^ Golgin 97 and Golgin 245 are dissociated from the Golgi when Arl 1 is knocked down by its siRNA . ^^^ Arl 1 GTP thus functions to recruit Golgin 97 and Golgin 245 onto the Golgi via interacting with their GRIP domains . . ^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| Autoantigen Golgin 97 , an effector of Arl 1 GTPase , participates in traffic from the endosome to the trans golgi network . ^^^ Knock down of Golgin 97 or Arl 1 by their respective small interference RNAs ( siRNAs ) also significantly inhibited the transport of STxB to the Golgi in vivo . ^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrate that ARFRP 1 is associated mainly with the trans Golgi compartment and the trans Golgi network ( TGN ) and is an essential regulatory factor for targeting of Arl 1 and GRIP domain containing proteins , golgin 97 and golgin 245 , onto Golgi membranes . ^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that Arl 1 regulates TGN recruitment of GRIP domain containing Golgin 97 and Golgin 245 by interacting with the conserved GRIP domain present in their carboxyl ( C ) termini . ^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of Arl 1 and golgin 97 in endosome to TGN transport using recombinant Shiga toxin B fragment . ^^^ We describe here the application of these assays to study the role of a small GTPase Arl 1 and its effector golgin 97 in this transport process . . ^^^ |
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| Interacting proteins: Q92805 and P40616 |
Pubmed |
SVM Score :0.0 |
| NA |
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