| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :1.0866718 |
| MOZ has recently been shown to interact directly with RUNX 1 , indicating that MOZ fusion proteins act by deregulating RUNX 1 function . 1.0866718^^^ |
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| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| Activation of AML 1 mediated transcription by MOZ and inhibition by the MOZ CBP fusion protein . ^^^ We report here that MOZ is part of the AML 1 complex and strongly stimulates AML 1 mediated transcription . ^^^ The stimulation of AML 1 mediated transcription is independent of the inherent HAT activity of MOZ . ^^^ Rather , a potent transactivation domain within MOZ appears to be essential for stimulation of AML 1 mediated transcription . ^^^ MOZ , as well as CBP and MOZ CBP , can acetylate AML 1 in vitro . ^^^ |
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| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| It has been reported that AML 1 is capable of interaction with histone acetyl transferases ( CBP , p 300 , and MOZ ) and with component of the histone deacetylase complex ( Sin 3 ) , and that the interaction with these coregulators affects the strength of AML 1 in promoter regulation . ^^^ |
|
| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| HIPK 2 also phosphorylates another co activator , MOZ , in an AML 1 dependent manner . ^^^ |
|
| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| Both wild type MOZ and MOZ TIF 2 were found to colocalize with AML 1 , and MOZ TIF 2 was recruited to an AML 1 target promoter . ^^^ A MOZ CBP fusion protein showed similar functions to MOZ TIF 2 in that it inhibited retinoic acid receptor mediated transcription but enhanced AML 1 reporter activation . ^^^ |
|
| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| MOZ acts as a transcriptional coactivator for AML 1 , which is essential for establishment of definitive hematopoiesis . ^^^ |
|
| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92794 and Q01196 |
Pubmed |
SVM Score :0.0 |
| NA |
|