| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.53337381 |
| MAT 1 , cyclin H and cdk 7 exist as a ternary complex either free or associated with TFIIH from which the latter can be dissociated at high salt concentration . 0.53337381^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Three subunits of TFIIH , cdk 7 , cyclin H and MAT 1 , form a ternary complex , cdk activating kinase ( CAK ) , found either on its own or as part of TFIIH . ^^^ TFIIH was resolved into four subcomplexes : the kinase complex composed of cdk 7 , cyclin H and MAT 1 ; the core TFIIH which contains XPB , p 62 , p 52 , p 44 and p 34 ; and two other subcomplexes in which XPD is found associated with either the kinase complex or with the core TFIIH . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Regulation of CDK 7 substrate specificity by MAT 1 and TFIIH . ^^^ We conclude that the substrate preference of the CDK 7 CycH kinase is governed by association with both MAT 1 and ' core ' TFIIH . . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Both free CAK ( cdk 7 , cyclin H , MAT 1 ) and the CAK containing general transcription factor TFIIH phosphorylated Ser 77 in vitro . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| The cdk 7 cyclin H MAT 1 complex associated with TFIIH is localized in coiled bodies . ^^^ TFIIH is composed of eight or nine subunits and we show that at least four of them , namely cdk 7 , cyclin H , MAT 1 , and p 62 are localized in the coiled body , a distinct subnuclear structure that is transcription dependent and highly enriched in small nuclear ribonucleoproteins . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| MAT 1 is known to be required for the assembly of cyclin dependent kinase ( CDK ) activating kinase ( CAK ) , which is functionally associated with the general transcription factor IIH ( TFIIH ) . ^^^ MAT 1 containing TFIIH was also shown to interact with POU domains of Oct 1 and Oct 2 . ^^^ These results suggest ( 1 ) that interactions between POU domains and MAT 1 can target CAK to Oct factors and result in their phosphorylation , ( 2 ) that MAT 1 not only functions as a CAK assembly factor but also acts to alter the spectrum of CAK substrates , and ( 3 ) that a POU MAT 1 interaction may play a role in the recruitment of TFIIH to the preinitiation complex or in subsequent initiation and elongation reactions . . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| The CDK 7 cyclin H MAT 1 complex is tightly associated with a multiprotein complex TFIIH , which plays a dual role in transcription and DNA repair . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| MAT 1 ) , that is found either free or as a component of the transcription / DNA repair factor TFIIH . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Distinct regions of MAT 1 regulate cdk 7 kinase and TFIIH transcription activities . ^^^ The median portion of MAT 1 , which contains a coiled coil motif , allows the binding of CAK to the TFIIH core through interactions with both XPD and XPB helicases . ^^^ Furthermore , using recombinant TFIIH complexes , it is demonstrated that the N terminal RING finger domain of MAT 1 is crucial for transcription activation and participates to the phosphorylation of the C terminal domain of the largest subunit of the RNA polymerase II . . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Cyclin dependent kinase 7 ( Cdk 7 ) forms a trimeric complex with cyclin H and Mat 1 to form the mammalian Cdk activating kinase , CAK , as well as a part of the basal transcription factor TFIIH , where Cdk 7 phosphorylates the C terminal domain ( CTD ) of the large subunit of RNA polymerase 2 . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Solution structure of the N terminal domain of the human TFIIH MAT 1 subunit : new insights into the RING finger family . ^^^ The human MAT 1 protein belongs to the cyclin dependent kinase activating kinase complex , which is functionally associated to the transcription / DNA repair factor TFIIH . ^^^ The N terminal region of MAT 1 consists of a C3HC4 RING finger , which contributes to optimal TFIIH transcriptional activities . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| The trimeric Cdk 7 cyclin H Mat 1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin dependent kinase ( Cdk ) activating kinase . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| When the ternary Cdk activating kinase ( CAK ) complex composed of Cdk 7 , cyclin H , and MAT 1 was used as bait , the xeroderma pigmentosum ( XP ) D helicase of transcription factor IIH ( TFIIH ) , among other proteins , was identified as an interacting partner . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Together with TFIIH subunits cyclin H and Mat 1 , Cdk 7 kinase is also found in a trimer complex known as Cdk activating kinase ( CAK ) . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| The kinase subunits of TFIIH in animal cells , Cdk 7 , cyclin H , and MAT 1 , were independently isolated as an activity termed CAK ( Cdk activating kinase ) , which phosphorylates and activates cell cycle kinases . ^^^ TFB 3 , the 38 kDa subunit of yeast TFIIH , is the homolog of mammalian MAT 1 . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| Conditional ablation of the Mat 1 subunit of TFIIH in Schwann cells provides evidence that Mat 1 is not required for general transcription . ^^^ The mammalian Mat 1 protein has been implicated in cell cycle regulation as part of the Cdk activating kinase ( CAK ) , and in regulation of transcription as a subunit of transcription factor TFIIH . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| MAT 1 is an assembly / targeting factor for cyclin dependent kinase activating kinase ( CAK ) , which has been shown to functionally interact with general transcriptional factor TFIIH , a known inducer of ER transactivation . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| General transcription factor IIH ( TFIIH ) consists of nine subunits : cyclin dependent kinase 7 ( Cdk 7 ) , cyclin H and MAT 1 ( forming the Cdk activating kinase or CAK complex ) , the two helicases Xpb / Hay and Xpd , and p 34 , p 44 , p 52 and p 62 ( refs 1 3 ) . ^^^ |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92759 and P51948 |
Pubmed |
SVM Score :0.0 |
| NA |
|