| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Core NER enzymes XPA , XPF , XPG , and TFIIH are essential for recovery . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Stable associations of the ERCC 1 complex with other known repair factors ( XPA , XPC , XPG and TFIIH complex ) could not be detected . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The incision reaction was then reconstituted with the purified proteins RPA , XPA , TFIIH ( containing XPB and XPD ) , XPC , UV DDB , XPG , partially purified ERCC1 / XPF complex , and a factor designated IF 7 . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The dual incision reaction was reconstituted using the purified mammalian proteins XPA , RPA , XPC , TFIIH , XPG , and a fraction containing ERCC 1 XPF and IF 7 . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Interactions involving the human RNA polymerase 2 transcription / nucleotide excision repair complex TFIIH , the nucleotide excision repair protein XPG , and Cockayne syndrome group B ( CSB ) protein . ^^^ Additionally we have examined interactions between TFIIH components , the human NER protein XPG , and the CSB protein which is implicated in Cockayne syndrome ( CS ) . ^^^ XPG protein interacts with multiple subunits of TFIIH and with CSB protein . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Furthermore , reconstitution of the human excision nuclease was observed with a mixture of five repair factors ( XPA , XPC , XPG , TFIIH , and RPA ) and the recombinant XPF ERCC 1 , thus verifying that no additional protein factors are needed for the specific dual incisions characteristic of human excision repair . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| For the bulk of mammalian DNA , the core protein factors needed for damage recognition and incision during nucleotide excision repair ( NER ) are the XPA protein , the heterotrimeric RPA protein , the 6 to 9 subunit TFIIH , the XPC hHR23B complex , the XPG nuclease , and the ERCC 1 XPF nuclease . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The dual incisions are accomplished by sequential and partly overlapping actions of six repair factors , RPA , XPA , XPC , TFIIH , XPG , and XPF . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The proteins known to be involved in the first steps of the NER reaction ( damage recognition and incision excision ) are heterotrimeric RPA , XPA , the 6 to 9 subunit TFIIH , XPC hHR23B , XPG , and ERCC 1 XPF . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| A set of proteins required for repair of most lesions is RPA , XPA , TFIIH , XPC hHR23B , XPG , and ERCC 1 XPF , but additional components have not been excluded . ^^^ To identify the forms of TFIIH that can function in repair , recombinant XPA , RPA , XPC hHR23B , XPG , and ERCC 1 XPF were combined with TFIIH fractions purified from HeLa cells . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Finally , damage DNA excision reaction on SV 40 minichromosomes was reconstituted with six highly purified NER factors , XPA , XPC HR23B , XPF ERCC 1 , XPG , RPA and TFIIH , as those essential for the reaction with naked DNA . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Transcription coupled repair of 8 oxoguanine : requirement for XPG , TFIIH , and CSB and implications for Cockayne syndrome . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH , XPG , and ERCC 1 XPF . ^^^ Furthermore , we reveal that TFIIH inhibits the structure specific endonuclease activities of both XPG and ERCC 1 XPF , responsible for the 3 ' and 5 ' incision in NER , respectively . ^^^ These results point toward additional roles for TFIIH and ATP during NER distinct from a requirement for DNA unwinding in the regulation of the endonuclease activities of XPG and ERCC 1 XPF . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair , without a preassembled repairosome . ^^^ In mammalian cells , the core factors involved in the damage recognition and incision steps of DNA nucleotide excision repair are XPA , TFIIH complex , XPC HR23B , replication protein A ( RPA ) , XPG , and ERCC 1 XPF . ^^^ At physiological ionic strength , TFIIH associated with significant amounts of XPC HR23B and XPG but not other repair factors . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Human nucleotide excision repair is initiated by six repair factors ( XPA , RPA , XPC HR23B , TFIIH , XPF ERCC 1 , and XPG ) which sequentially assemble at sites of DNA damage and effect excision of damage containing oligonucleotides . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Here , we provide evidence that CSB is found not only in the nucleoplasm but also in the nucleolus within a complex ( CSB IP / 150 ) that contains RNA pol 1 , TFIIH , and XPG and promotes efficient rRNA synthesis . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| XPA and RPA , once forming a complex at the damage site , would likely work with TFIIH , XPG , and ERCC 1 XPF for dual incision . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| We describe ( 1 ) the role of ATP in remodelling the NER initiating complex of XPC / TFIIH / damaged DNA as a prerequisite for the recruitment of the next NER factors ; ( 2 ) the coordination between damage removal and DNA resynthesis and the release of XPC HR23B , TFIIH and XPA upon arrival of XPG and XPF ERCC 1 , respectively ; ( 3 ) how RPA remains associated with the excised DNA initiating the assembly of resynthesis factors such as PCNA ; ( 4 ) the recycling of XPC HR23B , TFIIH and XPA in the NER ; and the shuttling of TFIIH between NER and transcription . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| In humans UV induced cyclobutane thymine dimers are excised by the joint action of six repair factors , RPA , XPA , XPC , TFIIH , XPG , and XPF . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| XPG and XPF / ERCC1 endonucleases then cut the damaged DNA at the limit of the opened structure that was previously `` labeled ' ' by the positioning of XPC / HR23B and TFIIH . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The subunit p 62 is a structural component of the TFIIH core that is known to interact with VP 16 , p 53 , Eralpha , and E2F1 in the context of activated transcription , as well as with the endonuclease XPG in DNA repair . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage . ^^^ Instead , this region is essential for interaction with TFIIH and for the stable recruitment of XPG to sites of local UV damage after the prior recruitment of TFIIH . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The spacer region is not required for endonuclease activity , but amino acids 111 550 contribute to the substrate specificity of XPG , and they are required for interaction with TFIIH and for NER activity in vitro and in vivo . ^^^ XPGDelta 184 210 and XPGDelta 554 730 are not observed at sites of local UV damage in living cells by immunofluorescence , suggesting that the weakened interaction between XPG and TFIIH results in an NER reaction with altered kinetics . ^^^ This study demonstrates that the N terminal portion of the spacer region is particularly important for NER progression by mediating the XPG TFIIH interaction and XPG substrate specificity . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The severe xeroderma pigmentosum / Cockayne syndrome ( XP / CS ) syndrome is caused by mutations in the XPB , XPD and XPG genes that encode the helicase subunits of TFIIH and the 3 ' endonuclease of nucleotide excision repair ( NER ) . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Recognition of RNA polymerase 2 and transcription bubbles by XPG , CSB , and TFIIH : insights for transcription coupled repair and Cockayne Syndrome . ^^^ Bound RNAPII blocks bubble incision by XPG , but an ATP hydrolysis dependent process involving TFIIH creates access to the junction , allowing incision . ^^^ Together , these results implicate coordinated recognition of stalled transcription by XPG and CSB in TCR initiation and suggest that TFIIH dependent remodeling of stalled RNAPII without release may be sufficient to allow repair . . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| Transcription coupled repair of 8 oxoguanine : requirement for XPG , TFIIH , and CSB and implications for Cockayne syndrome . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| This immobilized RNA pol IIO is used as ' bait ' to sequentially recruit TFIIH , XPA , RPA , XPG and XPF repair factors in an ATP dependent manner . ^^^ |
|
| Interacting proteins: P28715 and Q92759 |
Pubmed |
SVM Score :0.0 |
| The results obtained from our immunoprecipitation experiment further demonstrated that the ATM protein interacted with the TFIIH basal transcription factor and the XPG protein of the NER pathway . ^^^ |
|