| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.69466767 |
| An in vivo binding assay revealed that PCP 2 could directly interact with beta catenin through a region in the juxtamembrane domain . 0.69466767^^^ In conclusion , interaction of PCP 2 with its substrate beta catenin is involved in the process of cell cell contact . . 0.5896578^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.72692778 |
| To investigate which part of PCP 2 was involved in its interaction with beta catenin , we constructed various deletion mutants of PCP 2 . 0.72692778^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.57705265 |
| Confocal microscopy analysis shows that beta catenin colocalizes with LMW PTP at the plasma membrane . 0.57705265^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| As has been demonstrated for PTPs kappa and mu , PTP lambda mediates homotypic adhesion in vitro , and PTP lambda is associated with beta catenin in kidney epithelial cells . ^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| Interestingly , ectopic expression of protein tyrosine phosphatase ( PTP ) LAR inhibits epithelial cell migration by preventing phosphorylation and the increase in the free pool of beta catenin ; moreover , it inhibits tumor formation in nude mice . ^^^ These data support a function for PTP LAR in the regulation of epithelial cell cell contacts at adherens junctions as well as in the control of beta catenin signaling functions . ^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| Our data show that LMW PTP is oxidized and inactivated during Aplidin treatment , thus causing a hyper phosphorylation of its substrate beta catenin . ^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase PCP 2 inhibits beta catenin signaling and increases E cadherin dependent cell adhesion . beta Catenin is a key molecule involved in both cell adhesion and Wnt signaling pathway . ^^^ We have previously shown that receptor like protein tyrosine phosphatase PCP 2 localizes to the adherens junctions and directly binds and dephosphorylates beta catenin , suggesting that PCP 2 might regulate the balance between signaling and adhesive beta catenin . ^^^ Here we demonstrate that PCP 2 can inhibit both the wild type and constitutively active forms of beta catenin in activating target genes such as c myc . ^^^ The phosphatase activity of PCP 2 is required for this effect since loss of catalytic activity attenuates its inhibitory effect on beta catenin activation . ^^^ Expression of PCP 2 in SW 480 colon cancer cells can lead to stabilization of cytosolic pools of beta catenin perhaps , by virtue of their physical interaction . ^^^ |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92729 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|