| Interacting proteins: Q92556 and P84095 |
Pubmed |
SVM Score :0.0 |
| Phagocytosis of apoptotic cells is regulated by a UNC 73 / TRIO MIG 2 / RhoG signaling module and armadillo repeats of CED 12 / ELMO . ^^^ Complementary studies in C . elegans show that MIG 2 ( which we identify as the homolog of mammalian RhoG ) and UNC 73 ( the TRIO homolog ) also regulate corpse clearance in vivo , upstream of CED 12 . ^^^ At the molecular level , we identify a novel set of evolutionarily conserved Armadillo ( ARM ) repeats within CED 12 / ELMO that mediate an interaction with activated MIG 2 / RhoG ; this , in turn , promotes Dock 180 mediated Rac activation and cytoskeletal reorganization . ^^^ CONCLUSIONS : The combination of in vitro and in vivo studies presented here identify two evolutionarily conserved players in engulfment , TRIO / UNC73 and RhoG / MIG 2 , and the TRIO > RhoG signaling module is linked by ELMO / CED 12 to Dock 180 dependent Rac activation during engulfment . ^^^ This work also identifies ARM repeats within CED 12 / ELMO and their role in linking RhoG and Rac , two GTPases that function in tandem during engulfment . . ^^^ |
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| Interacting proteins: Q92556 and P84095 |
Pubmed |
SVM Score :0.0 |
| We mapped ERM binding on ELMO 1 to the N terminal 280 amino acids , which overlaps with the region required for binding to the GTPase RhoG , but is distinct from the C terminal Dock 180 binding region . ^^^ |
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| Interacting proteins: Q92556 and P84095 |
Pubmed |
SVM Score :0.0 |
| NA |
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