| Interacting proteins: Q92556 and P63000 |
Pubmed |
SVM Score :0.0 |
| CED 12 / ELMO 1 binds directly to CED 5 / Dock180 ; this evolutionarily conserved complex stimulates a Rac GEF , leading to Rac 1 activation and cytoskeletal rearrangements . ^^^ These studies identify CED 12 / ELMO as an upstream regulator of Rac 1 that affects engulfment and cell migration from C . elegans to mammals . . ^^^ |
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| Interacting proteins: Q92556 and P63000 |
Pubmed |
SVM Score :0.0 |
| Genetic studies in Caenorhabditis elegans identified an evolutionarily conserved CED 2 ( CrkII ) , CED 5 ( DOCK 180 ) , CED 12 ( ELMO ) , CED 10 ( Rac 1 ) module important for cell migration and phagocytosis of apoptotic cells . ^^^ |
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| Interacting proteins: Q92556 and P63000 |
Pubmed |
SVM Score :0.0 |
| In the first pathway , the proteins CED 2 , CED 5 and CED 12 ( mammalian homologues CrkII , Dock 180 and ELMO , respectively ) function to activate CED 10 ( Rac 1 ) . ^^^ |
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| Interacting proteins: Q92556 and P63000 |
Pubmed |
SVM Score :0.0 |
| We can also detect a trimeric ELMO 1 Dock180 Rac 1 complex and ELMO augments the interaction between Dock 180 and Rac . ^^^ |
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