| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.72532621 |
| In mammalian cells , ELMO 1 functionally cooperates with CrkII and Dock 180 to promote phagocytosis and cell shape changes . 0.72532621^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| We present evidence showing Crk ( an adaptor molecule ) , Mbc , ELMO ( a homolog of Caenorhabditis elegans CED 12 and mammalian ELMO ) , and Rac to be mediators of JNK activation by PVR . ^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| The second C . elegans pathway acts in parallel and involves a novel Rac GTPase signaling pathway , with the components CED 2 CrkII , CED 5 DOCK 180 , CED 12 ELMO , and CED 10 Rac . ^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| Genetic studies in Caenorhabditis elegans identified an evolutionarily conserved CED 2 ( CrkII ) , CED 5 ( DOCK 180 ) , CED 12 ( ELMO ) , CED 10 ( Rac 1 ) module important for cell migration and phagocytosis of apoptotic cells . ^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| In the first pathway , the proteins CED 2 , CED 5 and CED 12 ( mammalian homologues CrkII , Dock 180 and ELMO , respectively ) function to activate CED 10 ( Rac 1 ) . ^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| These mutants displayed comparable binding to Dock 180 and Crk as wild type ELMO 1 , but gave a lowered activation of Rac . ^^^ The data suggest that Src family kinase mediated tyrosine phosphorylation of ELMO 1 might represent an important regulatory mechanism that controls signaling through the ELMO1 / Crk / Dock180 pathway . . ^^^ |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92556 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|