| Interacting proteins: Q8WZA2 and Q9UQ26 |
Pubmed |
SVM Score :0.92011322 |
| We also show that cAMP GEFII , through its interaction with Rim 2 , mediates cAMP induced , Ca2+ dependent secretion that is not blocked by an inhibitor of cAMP dependent protein kinase ( PKA ) . 0.92011322^^^ |
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| Interacting proteins: Q8WZA2 and Q9UQ26 |
Pubmed |
SVM Score :0.0 |
| Critical role of cAMP GEFII Rim 2 complex in incretin potentiated insulin secretion . ^^^ We recently found that the cAMP binding protein cAMP GEFII ( or Epac 2 ) , interacting with Rim 2 , a target of the small G protein Rab 3 , mediates cAMP dependent , PKA independent exocytosis in a reconstituted system . ^^^ In the present study , we investigated the role of the cAMP GEFII Rim 2 pathway in incretin potentiated insulin secretion in native pancreatic beta cells . ^^^ The effect of cAMP GEFII on insulin secretion is mediated by Rim 2 and depends on intracellular calcium as well as on cAMP . ^^^ These results indicate that the PKA independent mechanism involving the cAMP GEFII Rim 2 pathway is critical in the potentiation of insulin secretion by incretins . . ^^^ |
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| Interacting proteins: Q8WZA2 and Q9UQ26 |
Pubmed |
SVM Score :0.0 |
| In the present investigation , we have discovered that Piccolo , a CAZ ( cytoskeletal matrix associated with the active zone ) protein in neurons that is structurally related to Rim 2 , also binds to cAMP GEFII and that it forms both homodimer and heterodimer with Rim 2 in a Ca ( 2+ ) dependent manner , whereas Rim 2 alone does not form the homodimer . ^^^ |
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| Interacting proteins: Q8WZA2 and Q9UQ26 |
Pubmed |
SVM Score :0.0 |
| The ATP sensitive K ( + ) channel , acting as the ATP sensor , couples cell metabolism to membrane potential . cAMP GEFII , acting as a cAMP sensor , mediates cAMP dependent , protein kinase A independent exocytosis , which requires interaction with both Piccolo as a Ca ( 2+ ) sensor and Rim 2 as a Rab 3 effector . l type voltage dependent Ca ( 2+ ) channels ( VDCCs ) regulate Ca ( 2+ ) influx . ^^^ Localization of cAMP GEFII overlaps with that of Rim 2 in plasma membrane of insulin secreting MIN 6 cells . ^^^ |
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