| Identification and characterization of a novel BASH N terminus associated protein , BNAS 2 . ^^^ Using the yeast two hybrid system , we have identified a novel protein that binds to a conserved N terminal domain of BASH , which we named BNAS 2 ( BASH N terminus associated protein 2 ) . ^^^ BNAS 2 was co precipitated with BASH as well as Btk and ERK 2 from a lysate of mouse B cell line . ^^^ BASH was co localized with BNAS 2 in a manner dependent on its N terminal domain . ^^^ Thus BNAS 2 may serve as a scaffold for signaling proteins such as BASH , Btk , and ERK at the ER and nuclear membrane and may facilitate ERK activation by signaling from cell surface receptors . . ^^^ |